Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054677186> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2054677186 endingPage "540" @default.
- W2054677186 startingPage "536" @default.
- W2054677186 abstract "Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro. Activity-guided fractionation led to the isolation of four naphthoquinones from both the root and stem bark of the plant. The compounds were identified as 2-(1-hydroxyethyl)-naphtho[2,3-b]furan-4,9-quinone (1), isopinnatal (2), kigelinol (3), and isokigelinol (4). Subsequently, the compounds were assessed for antitrypanosomal activity against T. brucei brucei and T. brucei rhodesiense bloodstream form trypomastigotes in vitro. Compound 1 with a furanonaphthoquinone structure was found to possess pronounced activity against both parasites with IC50 values of 0.12 and 0.045 microM, respectively, although it was less active than the standard drug pentamidine. Compounds 2, 3, and 4 also exhibited activity against the parasites, although to a lesser extent. The activities of the compounds were further assessed by comparison with the cytotoxic activities obtained against KB cell lines." @default.
- W2054677186 created "2016-06-24" @default.
- W2054677186 creator A5009141000 @default.
- W2054677186 creator A5017387730 @default.
- W2054677186 creator A5049292941 @default.
- W2054677186 creator A5053604740 @default.
- W2054677186 creator A5082897881 @default.
- W2054677186 date "1999-08-01" @default.
- W2054677186 modified "2023-10-14" @default.
- W2054677186 title "Activity of Extracts and Naphthoquinones from Kigelia pinnata Against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense" @default.
- W2054677186 doi "https://doi.org/10.1055/s-1999-14011" @default.
- W2054677186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10483374" @default.
- W2054677186 hasPublicationYear "1999" @default.
- W2054677186 type Work @default.
- W2054677186 sameAs 2054677186 @default.
- W2054677186 citedByCount "58" @default.
- W2054677186 countsByYear W20546771862012 @default.
- W2054677186 countsByYear W20546771862013 @default.
- W2054677186 countsByYear W20546771862014 @default.
- W2054677186 countsByYear W20546771862015 @default.
- W2054677186 countsByYear W20546771862016 @default.
- W2054677186 countsByYear W20546771862018 @default.
- W2054677186 countsByYear W20546771862019 @default.
- W2054677186 countsByYear W20546771862020 @default.
- W2054677186 countsByYear W20546771862021 @default.
- W2054677186 countsByYear W20546771862022 @default.
- W2054677186 crossrefType "journal-article" @default.
- W2054677186 hasAuthorship W2054677186A5009141000 @default.
- W2054677186 hasAuthorship W2054677186A5017387730 @default.
- W2054677186 hasAuthorship W2054677186A5049292941 @default.
- W2054677186 hasAuthorship W2054677186A5053604740 @default.
- W2054677186 hasAuthorship W2054677186A5082897881 @default.
- W2054677186 hasConcept C104317684 @default.
- W2054677186 hasConcept C133446333 @default.
- W2054677186 hasConcept C142724271 @default.
- W2054677186 hasConcept C18903297 @default.
- W2054677186 hasConcept C202751555 @default.
- W2054677186 hasConcept C2776635100 @default.
- W2054677186 hasConcept C2779502636 @default.
- W2054677186 hasConcept C2781421772 @default.
- W2054677186 hasConcept C2909346784 @default.
- W2054677186 hasConcept C55493867 @default.
- W2054677186 hasConcept C556039675 @default.
- W2054677186 hasConcept C71924100 @default.
- W2054677186 hasConcept C86803240 @default.
- W2054677186 hasConceptScore W2054677186C104317684 @default.
- W2054677186 hasConceptScore W2054677186C133446333 @default.
- W2054677186 hasConceptScore W2054677186C142724271 @default.
- W2054677186 hasConceptScore W2054677186C18903297 @default.
- W2054677186 hasConceptScore W2054677186C202751555 @default.
- W2054677186 hasConceptScore W2054677186C2776635100 @default.
- W2054677186 hasConceptScore W2054677186C2779502636 @default.
- W2054677186 hasConceptScore W2054677186C2781421772 @default.
- W2054677186 hasConceptScore W2054677186C2909346784 @default.
- W2054677186 hasConceptScore W2054677186C55493867 @default.
- W2054677186 hasConceptScore W2054677186C556039675 @default.
- W2054677186 hasConceptScore W2054677186C71924100 @default.
- W2054677186 hasConceptScore W2054677186C86803240 @default.
- W2054677186 hasIssue "6" @default.
- W2054677186 hasLocation W20546771861 @default.
- W2054677186 hasLocation W20546771862 @default.
- W2054677186 hasOpenAccess W2054677186 @default.
- W2054677186 hasPrimaryLocation W20546771861 @default.
- W2054677186 hasRelatedWork W1974741353 @default.
- W2054677186 hasRelatedWork W2041265878 @default.
- W2054677186 hasRelatedWork W2046967555 @default.
- W2054677186 hasRelatedWork W2051133186 @default.
- W2054677186 hasRelatedWork W2058190829 @default.
- W2054677186 hasRelatedWork W2320373846 @default.
- W2054677186 hasRelatedWork W2476143785 @default.
- W2054677186 hasRelatedWork W2942344826 @default.
- W2054677186 hasRelatedWork W3160577198 @default.
- W2054677186 hasRelatedWork W4381839032 @default.
- W2054677186 hasVolume "65" @default.
- W2054677186 isParatext "false" @default.
- W2054677186 isRetracted "false" @default.
- W2054677186 magId "2054677186" @default.
- W2054677186 workType "article" @default.