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- W2054686908 endingPage "5019" @default.
- W2054686908 startingPage "5002" @default.
- W2054686908 abstract "Dietary flavones have promising chemoprotective properties, in particular with regard to cancer, but problems with low oral bioavailability and sometimes unacceptable toxicity have made their use as protective additives to normal diets questionable. However, methylation of free phenolic hydroxyl groups leads to derivatives not susceptible to glucuronic acid or sulfate conjugation, resulting in increased metabolic stability. Methylation also leads to greatly improved transport through biological membranes, such as in intestinal absorption, and much increased oral bioavailability. Recent studies also indicate that methylation results in derivatives with increasing potency to kill cancer cells. They also show high potency towards inhibition of hormone-regulating enzymes, e.g., aromatase, important in the causation of breast cancer. Methylation of the flavones may also result in derivatives with diminished toxic side-effects and improved aqueous solubility. In conclusion, it appears that methylation of dietary flavones as well as of other food products may produce derivatives with much improved health effects." @default.
- W2054686908 created "2016-06-24" @default.
- W2054686908 creator A5018025297 @default.
- W2054686908 date "2009-11-18" @default.
- W2054686908 modified "2023-10-01" @default.
- W2054686908 title "Methylation of Dietary Flavones Increases Their Metabolic Stability and Chemopreventive Effects" @default.
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- W2054686908 cites W1974846806 @default.
- W2054686908 cites W1979196526 @default.
- W2054686908 cites W1983938442 @default.
- W2054686908 cites W1984799211 @default.
- W2054686908 cites W1986791286 @default.
- W2054686908 cites W1989950716 @default.
- W2054686908 cites W1990979855 @default.
- W2054686908 cites W1993923229 @default.
- W2054686908 cites W1996315798 @default.
- W2054686908 cites W1997731119 @default.
- W2054686908 cites W1999884517 @default.
- W2054686908 cites W2002205161 @default.
- W2054686908 cites W2005456063 @default.
- W2054686908 cites W2008151923 @default.
- W2054686908 cites W2008905101 @default.
- W2054686908 cites W2009741021 @default.
- W2054686908 cites W2011210734 @default.
- W2054686908 cites W2032336626 @default.
- W2054686908 cites W2034422233 @default.
- W2054686908 cites W2036268709 @default.
- W2054686908 cites W2038399339 @default.
- W2054686908 cites W2039183399 @default.
- W2054686908 cites W2045336410 @default.
- W2054686908 cites W2046525105 @default.
- W2054686908 cites W2046650127 @default.
- W2054686908 cites W2048013290 @default.
- W2054686908 cites W2050244937 @default.
- W2054686908 cites W2051699773 @default.
- W2054686908 cites W2052533230 @default.
- W2054686908 cites W2055770285 @default.
- W2054686908 cites W2060084080 @default.
- W2054686908 cites W2061092694 @default.
- W2054686908 cites W2062269191 @default.
- W2054686908 cites W2062302378 @default.
- W2054686908 cites W2067615424 @default.
- W2054686908 cites W2074942025 @default.
- W2054686908 cites W2076358165 @default.
- W2054686908 cites W2078166953 @default.
- W2054686908 cites W2078436865 @default.
- W2054686908 cites W2080719184 @default.
- W2054686908 cites W2081538782 @default.
- W2054686908 cites W2086861590 @default.
- W2054686908 cites W2088015762 @default.
- W2054686908 cites W2089293776 @default.
- W2054686908 cites W2092864619 @default.
- W2054686908 cites W2092994052 @default.
- W2054686908 cites W2093493007 @default.
- W2054686908 cites W2095867952 @default.
- W2054686908 cites W2099433520 @default.
- W2054686908 cites W2107673483 @default.
- W2054686908 cites W2109335148 @default.
- W2054686908 cites W2114733293 @default.
- W2054686908 cites W2119627765 @default.
- W2054686908 cites W2124858706 @default.
- W2054686908 cites W2125565767 @default.
- W2054686908 cites W2132772974 @default.
- W2054686908 cites W2132945004 @default.
- W2054686908 cites W2135145833 @default.
- W2054686908 cites W2136830554 @default.
- W2054686908 cites W2136912731 @default.
- W2054686908 cites W2142973990 @default.
- W2054686908 cites W2143767136 @default.
- W2054686908 cites W2144618543 @default.
- W2054686908 cites W2144843569 @default.
- W2054686908 cites W2147137265 @default.
- W2054686908 cites W2149169850 @default.
- W2054686908 cites W2156445427 @default.
- W2054686908 cites W2159726281 @default.
- W2054686908 cites W2159874325 @default.
- W2054686908 cites W2161780922 @default.
- W2054686908 cites W2165669901 @default.
- W2054686908 cites W2171258641 @default.
- W2054686908 cites W2242032302 @default.
- W2054686908 cites W2329983604 @default.
- W2054686908 cites W2331766982 @default.
- W2054686908 cites W584897690 @default.
- W2054686908 doi "https://doi.org/10.3390/ijms10115002" @default.
- W2054686908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2808020" @default.
- W2054686908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20087474" @default.
- W2054686908 hasPublicationYear "2009" @default.
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