FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054689747> ?p ?o ?g. }

• W2054689747 endingPage "728" @default.
• W2054689747 startingPage "720" @default.
• W2054689747 abstract "The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose treatment with EPO seems to improve neurological function of stroke patients but may be associated with increased thrombotic risk, whereas alternative non-erythropoietic neuroprotective derivatives of EPO, such as carbamylated EPO (CEPO), may be devoid of such side-effects. We investigated the effects of short-term, high-dose treatment with EPO and CEPO on platelet function and haemostasis in healthy mice and rats. Animals received three daily doses of EPO or CEPO (50 microg/kg), and blood was compared with respect to alterations in haematology and platelet reactivity. In rats, treatment with EPO increased the haematocrit to >50% and the mean platelet volume by 37%, while CEPO had no effect on these parameters. Platelets from EPO-treated rats showed an increased sensitivity to thrombin receptor agonist peptides and elevated plasma levels of soluble P-selectin (sP-selectin) were found in treated mice. Further indicators of platelet hyperreactivity in EPO, but not CEPO-treated animals, were significantly increased aggregatory responses to collagen in whole blood and platelet-rich plasma (PRP). The increased platelet reactivity was paralleled by a decreased bleeding time after tail transection in rats. Samples from EPO-treated rats showed an attenuated response to ADP in whole blood aggregometry and thrombelastography (TEG) platelet mapping but not in apyrase-treated PRP, suggesting involvement of ADP receptor desensitization. These findings suggest that while EPO affects various aspects of platelet function, CEPO is devoid of such effects." @default.
• W2054689747 created "2016-06-24" @default.
• W2054689747 creator A5003618240 @default.
• W2054689747 creator A5015807294 @default.
• W2054689747 creator A5022661690 @default.
• W2054689747 creator A5034015416 @default.
• W2054689747 creator A5040795838 @default.
• W2054689747 creator A5054826044 @default.
• W2054689747 creator A5065158992 @default.
• W2054689747 creator A5071467664 @default.
• W2054689747 creator A5074969584 @default.
• W2054689747 creator A5088436447 @default.
• W2054689747 date "2008-01-01" @default.
• W2054689747 modified "2023-10-05" @default.
• W2054689747 title "High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO)" @default.
• W2054689747 cites W11448426 @default.
• W2054689747 cites W145118746 @default.
• W2054689747 cites W1499904920 @default.
• W2054689747 cites W1514245259 @default.
• W2054689747 cites W1514768753 @default.
• W2054689747 cites W170849090 @default.
• W2054689747 cites W1964771978 @default.
• W2054689747 cites W1964793052 @default.
• W2054689747 cites W1968858911 @default.
• W2054689747 cites W1971341108 @default.
• W2054689747 cites W1980478112 @default.
• W2054689747 cites W1980687503 @default.
• W2054689747 cites W1988200805 @default.
• W2054689747 cites W1991806243 @default.
• W2054689747 cites W1998004065 @default.
• W2054689747 cites W2007588822 @default.
• W2054689747 cites W2013850625 @default.
• W2054689747 cites W2018271117 @default.
• W2054689747 cites W2019782074 @default.
• W2054689747 cites W2028262181 @default.
• W2054689747 cites W2039728906 @default.
• W2054689747 cites W2042367750 @default.
• W2054689747 cites W2048213435 @default.
• W2054689747 cites W2049449845 @default.
• W2054689747 cites W2070450284 @default.
• W2054689747 cites W2077030445 @default.
• W2054689747 cites W2082036505 @default.
• W2054689747 cites W2083615852 @default.
• W2054689747 cites W2087261587 @default.
• W2054689747 cites W2094165764 @default.
• W2054689747 cites W2095631860 @default.
• W2054689747 cites W2096315840 @default.
• W2054689747 cites W2106292297 @default.
• W2054689747 cites W2109364373 @default.
• W2054689747 cites W2109723592 @default.
• W2054689747 cites W2111144499 @default.
• W2054689747 cites W2120231263 @default.
• W2054689747 cites W2122965222 @default.
• W2054689747 cites W2126979588 @default.
• W2054689747 cites W2135826900 @default.
• W2054689747 cites W2143708434 @default.
• W2054689747 cites W2165452922 @default.
• W2054689747 cites W2171200724 @default.
• W2054689747 cites W22980151 @default.
• W2054689747 cites W2332849411 @default.
• W2054689747 cites W2355563412 @default.
• W2054689747 cites W2412219670 @default.
• W2054689747 cites W2416513543 @default.
• W2054689747 doi "https://doi.org/10.1160/th07-03-0208" @default.
• W2054689747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18392330" @default.
• W2054689747 hasPublicationYear "2008" @default.
• W2054689747 type Work @default.
• W2054689747 sameAs 2054689747 @default.
• W2054689747 citedByCount "49" @default.
• W2054689747 countsByYear W20546897472012 @default.
• W2054689747 countsByYear W20546897472013 @default.
• W2054689747 countsByYear W20546897472014 @default.
• W2054689747 countsByYear W20546897472015 @default.
• W2054689747 countsByYear W20546897472016 @default.
• W2054689747 countsByYear W20546897472017 @default.
• W2054689747 countsByYear W20546897472019 @default.
• W2054689747 countsByYear W20546897472020 @default.
• W2054689747 crossrefType "journal-article" @default.
• W2054689747 hasAuthorship W2054689747A5003618240 @default.
• W2054689747 hasAuthorship W2054689747A5015807294 @default.
• W2054689747 hasAuthorship W2054689747A5022661690 @default.
• W2054689747 hasAuthorship W2054689747A5034015416 @default.
• W2054689747 hasAuthorship W2054689747A5040795838 @default.
• W2054689747 hasAuthorship W2054689747A5054826044 @default.
• W2054689747 hasAuthorship W2054689747A5065158992 @default.
• W2054689747 hasAuthorship W2054689747A5071467664 @default.
• W2054689747 hasAuthorship W2054689747A5074969584 @default.
• W2054689747 hasAuthorship W2054689747A5088436447 @default.
• W2054689747 hasBestOaLocation W20546897472 @default.
• W2054689747 hasConcept C126322002 @default.
• W2054689747 hasConcept C134018914 @default.
• W2054689747 hasConcept C170493617 @default.
• W2054689747 hasConcept C190481736 @default.
• W2054689747 hasConcept C25498285 @default.
• W2054689747 hasConcept C2778534260 @default.
• W2054689747 hasConcept C2778938600 @default.
• W2054689747 hasConcept C2779216453 @default.
• W2054689747 hasConcept C2993802102 @default.

• next