FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054691942> ?p ?o ?g. }

• W2054691942 endingPage "1499" @default.
• W2054691942 startingPage "1492" @default.
• W2054691942 abstract "Although D2 dopamine receptors have been localized to olfactory receptor neurons (ORNs) and dopamine has been shown to modulate voltage-gated ion channels in ORNs, dopaminergic modulation of either odor responses or excitability in mammalian ORNs has not previously been demonstrated. We found that <50 microM dopamine reversibly suppresses odor-induced Ca2+ transients in ORNs. Confocal laser imaging of 300-microm-thick slices of neonatal mouse olfactory epithelium loaded with the Ca(2+)-indicator dye fluo-4 AM revealed that dopaminergic suppression of odor responses could be blocked by the D2 dopamine receptor antagonist sulpiride (<500 microM). The dopamine-induced suppression of odor responses was completely reversed by 100 microM nifedipine, suggesting that D2 receptor activation leads to an inhibition of L-type Ca2+ channels in ORNs. In addition, dopamine reversibly reduced ORN excitability as evidenced by reduced amplitude and frequency of Ca2+ transients in response to elevated K(+), which activates voltage-gated Ca2+ channels in ORNs. As with the suppression of odor responses, the effects of dopamine on ORN excitability were blocked by the D2 dopamine receptor antagonist sulpiride (<500 microM). The observation of dopaminergic modulation of odor-induced Ca2+ transients in ORNs adds to the growing body of work showing that olfactory receptor neurons can be modulated at the periphery. Dopamine concentrations in nasal mucus increase in response to noxious stimuli, and thus D2 receptor-mediated suppression of voltage-gated Ca2+ channels may be a novel neuroprotective mechanism for ORNs." @default.
• W2054691942 created "2016-06-24" @default.
• W2054691942 creator A5008007274 @default.
• W2054691942 creator A5017850162 @default.
• W2054691942 date "2004-04-01" @default.
• W2054691942 modified "2023-10-11" @default.
• W2054691942 title "Dopamine Reduces Odor- and Elevated-K⁺-Induced Calcium Responses in Mouse Olfactory Receptor Neurons In Situ" @default.
• W2054691942 cites W1484628435 @default.
• W2054691942 cites W1529840144 @default.
• W2054691942 cites W1548069410 @default.
• W2054691942 cites W1580513152 @default.
• W2054691942 cites W1619426618 @default.
• W2054691942 cites W1751041280 @default.
• W2054691942 cites W1946561635 @default.
• W2054691942 cites W1974004171 @default.
• W2054691942 cites W1982421019 @default.
• W2054691942 cites W1984362806 @default.
• W2054691942 cites W1985891688 @default.
• W2054691942 cites W1995659501 @default.
• W2054691942 cites W2000374524 @default.
• W2054691942 cites W2007786915 @default.
• W2054691942 cites W2012121921 @default.
• W2054691942 cites W2022795707 @default.
• W2054691942 cites W2049533240 @default.
• W2054691942 cites W2075313000 @default.
• W2054691942 cites W2078365367 @default.
• W2054691942 cites W2085061496 @default.
• W2054691942 cites W2087179850 @default.
• W2054691942 cites W2092407358 @default.
• W2054691942 cites W2104591201 @default.
• W2054691942 cites W2107680882 @default.
• W2054691942 cites W2127128780 @default.
• W2054691942 cites W2128587499 @default.
• W2054691942 cites W2140651496 @default.
• W2054691942 cites W2157133007 @default.
• W2054691942 cites W2164803276 @default.
• W2054691942 cites W2167062624 @default.
• W2054691942 cites W2275748005 @default.
• W2054691942 cites W2410678179 @default.
• W2054691942 doi "https://doi.org/10.1152/jn.00670.2003" @default.
• W2054691942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2955887" @default.
• W2054691942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14657189" @default.
• W2054691942 hasPublicationYear "2004" @default.
• W2054691942 type Work @default.
• W2054691942 sameAs 2054691942 @default.
• W2054691942 citedByCount "33" @default.
• W2054691942 countsByYear W20546919422012 @default.
• W2054691942 countsByYear W20546919422013 @default.
• W2054691942 countsByYear W20546919422014 @default.
• W2054691942 countsByYear W20546919422016 @default.
• W2054691942 countsByYear W20546919422022 @default.
• W2054691942 countsByYear W20546919422023 @default.
• W2054691942 crossrefType "journal-article" @default.
• W2054691942 hasAuthorship W2054691942A5008007274 @default.
• W2054691942 hasAuthorship W2054691942A5017850162 @default.
• W2054691942 hasBestOaLocation W20546919422 @default.
• W2054691942 hasConcept C120069818 @default.
• W2054691942 hasConcept C126322002 @default.
• W2054691942 hasConcept C134018914 @default.
• W2054691942 hasConcept C137183658 @default.
• W2054691942 hasConcept C169760540 @default.
• W2054691942 hasConcept C185592680 @default.
• W2054691942 hasConcept C201792869 @default.
• W2054691942 hasConcept C2778916471 @default.
• W2054691942 hasConcept C2779980732 @default.
• W2054691942 hasConcept C2780806966 @default.
• W2054691942 hasConcept C44208683 @default.
• W2054691942 hasConcept C513476851 @default.
• W2054691942 hasConcept C71924100 @default.
• W2054691942 hasConcept C86803240 @default.
• W2054691942 hasConceptScore W2054691942C120069818 @default.
• W2054691942 hasConceptScore W2054691942C126322002 @default.
• W2054691942 hasConceptScore W2054691942C134018914 @default.
• W2054691942 hasConceptScore W2054691942C137183658 @default.
• W2054691942 hasConceptScore W2054691942C169760540 @default.
• W2054691942 hasConceptScore W2054691942C185592680 @default.
• W2054691942 hasConceptScore W2054691942C201792869 @default.
• W2054691942 hasConceptScore W2054691942C2778916471 @default.
• W2054691942 hasConceptScore W2054691942C2779980732 @default.
• W2054691942 hasConceptScore W2054691942C2780806966 @default.
• W2054691942 hasConceptScore W2054691942C44208683 @default.
• W2054691942 hasConceptScore W2054691942C513476851 @default.
• W2054691942 hasConceptScore W2054691942C71924100 @default.
• W2054691942 hasConceptScore W2054691942C86803240 @default.
• W2054691942 hasIssue "4" @default.
• W2054691942 hasLocation W20546919421 @default.
• W2054691942 hasLocation W20546919422 @default.
• W2054691942 hasLocation W20546919423 @default.
• W2054691942 hasLocation W20546919424 @default.
• W2054691942 hasOpenAccess W2054691942 @default.
• W2054691942 hasPrimaryLocation W20546919421 @default.
• W2054691942 hasRelatedWork W1971409205 @default.
• W2054691942 hasRelatedWork W1990268056 @default.
• W2054691942 hasRelatedWork W2003665469 @default.
• W2054691942 hasRelatedWork W2016503752 @default.
• W2054691942 hasRelatedWork W2038380564 @default.
• W2054691942 hasRelatedWork W2043585202 @default.
• W2054691942 hasRelatedWork W2134116919 @default.

• next