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- W2054692302 endingPage "1662" @default.
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- W2054692302 abstract "Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic corticotropin-releasing hormone messenger RNA. Each measure was significantly correlated with the frequency of maternal licking and grooming (all r's > -0.6). These findings suggest that maternal behavior serves to program hypothalamic-pituitary-adrenal responses to stress in the offspring." @default.
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- W2054692302 date "1997-09-12" @default.
- W2054692302 modified "2023-10-10" @default.
- W2054692302 title "Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress" @default.
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- W2054692302 doi "https://doi.org/10.1126/science.277.5332.1659" @default.
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