FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054693521> ?p ?o ?g. }

• W2054693521 endingPage "628" @default.
• W2054693521 startingPage "619" @default.
• W2054693521 abstract "We previously found that a canine model of selective surgical ventricular denervation (VD), which does not permit increased sympathetic tone during the pathogenesis of heart failure (HF), tolerated the development of HF better than controls. To investigate the cellular mechanisms, we examined cellular contraction and L-type Ca(2+) channel currents (I(Ca)) and their responses to beta-adrenergic receptor (beta-AR) stimulation in left ventricular myocytes from 1) control, 2) VD, 3) HF induced by rapid pacing, and 4) HF induced in VD (VD-HF) dogs. The magnitude of myocyte contraction and rate of relaxation in VD were similar to control but were depressed in both HF and VD-HF. These changes were associated with reduced protein expression of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) and protein kinase A phosphorylated phospholamban (PLB), which was reduced in HF, but essentially abolished in VD-HF. beta-AR kinase (GRK2) was increased in HF but reduced in VD-HF. Basal I(Ca) density did not differ among control, VD, and HF groups, but VD-HF myocytes showed a markedly reduced I(Ca) density (approximately 40%). Compared to controls, the sensitivity of I(Ca) to isoproterenol (ISO), was significantly higher in VD, but reduced in HF. While I(Ca) responses to ISO in VD-HF were maintained at control levels, the amplitude of the ISO-stimulated I(Ca) was significantly smaller (approximately 50%) compared with HF myocytes. The relative decrease in Ca(2+) influx due to downregulation of I(Ca) density may contribute to the cardioprotective effects in VD-HF hearts by preventing Ca(2+) overload during the development of HF. These findings, in combination with the virtual abolition of phosphorylated PLB in VD-HF and the decrease in GRK2, may explain, in part, why VD dogs tolerate the development of HF better than control dogs." @default.
• W2054693521 created "2016-06-24" @default.
• W2054693521 creator A5006821145 @default.
• W2054693521 creator A5026372549 @default.
• W2054693521 creator A5043214832 @default.
• W2054693521 creator A5048724571 @default.
• W2054693521 creator A5051551818 @default.
• W2054693521 creator A5056890673 @default.
• W2054693521 creator A5087806461 @default.
• W2054693521 creator A5089364503 @default.
• W2054693521 creator A5091383588 @default.
• W2054693521 date "2006-05-01" @default.
• W2054693521 modified "2023-10-16" @default.
• W2054693521 title "Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart" @default.
• W2054693521 cites W1546712321 @default.
• W2054693521 cites W1848607724 @default.
• W2054693521 cites W1966331438 @default.
• W2054693521 cites W1980445909 @default.
• W2054693521 cites W1988792839 @default.
• W2054693521 cites W1994759225 @default.
• W2054693521 cites W2001105552 @default.
• W2054693521 cites W2006274777 @default.
• W2054693521 cites W2019435811 @default.
• W2054693521 cites W2023929054 @default.
• W2054693521 cites W2037993075 @default.
• W2054693521 cites W2040543880 @default.
• W2054693521 cites W2050824263 @default.
• W2054693521 cites W2054554932 @default.
• W2054693521 cites W2054635454 @default.
• W2054693521 cites W2055375040 @default.
• W2054693521 cites W2063776820 @default.
• W2054693521 cites W2064194947 @default.
• W2054693521 cites W2068711984 @default.
• W2054693521 cites W2070443489 @default.
• W2054693521 cites W2071526303 @default.
• W2054693521 cites W2077558166 @default.
• W2054693521 cites W2088236700 @default.
• W2054693521 cites W2090502913 @default.
• W2054693521 cites W2092493326 @default.
• W2054693521 cites W2103446573 @default.
• W2054693521 cites W2107992067 @default.
• W2054693521 cites W2108453642 @default.
• W2054693521 cites W2109585781 @default.
• W2054693521 cites W2112735350 @default.
• W2054693521 cites W2121814476 @default.
• W2054693521 cites W2122728009 @default.
• W2054693521 cites W2124547389 @default.
• W2054693521 cites W2125468282 @default.
• W2054693521 cites W2127926880 @default.
• W2054693521 cites W2129439677 @default.
• W2054693521 cites W2144276252 @default.
• W2054693521 cites W2149495528 @default.
• W2054693521 cites W2150560936 @default.
• W2054693521 cites W2166375411 @default.
• W2054693521 cites W2167525963 @default.
• W2054693521 cites W2167757221 @default.
• W2054693521 cites W2169617094 @default.
• W2054693521 cites W2398549444 @default.
• W2054693521 cites W2430030570 @default.
• W2054693521 cites W2614496215 @default.
• W2054693521 cites W2977097895 @default.
• W2054693521 cites W382567484 @default.
• W2054693521 cites W2183045642 @default.
• W2054693521 doi "https://doi.org/10.1016/j.yjmcc.2006.02.002" @default.
• W2054693521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16600289" @default.
• W2054693521 hasPublicationYear "2006" @default.
• W2054693521 type Work @default.
• W2054693521 sameAs 2054693521 @default.
• W2054693521 citedByCount "17" @default.
• W2054693521 countsByYear W20546935212016 @default.
• W2054693521 countsByYear W20546935212017 @default.
• W2054693521 countsByYear W20546935212019 @default.
• W2054693521 countsByYear W20546935212020 @default.
• W2054693521 crossrefType "journal-article" @default.
• W2054693521 hasAuthorship W2054693521A5006821145 @default.
• W2054693521 hasAuthorship W2054693521A5026372549 @default.
• W2054693521 hasAuthorship W2054693521A5043214832 @default.
• W2054693521 hasAuthorship W2054693521A5048724571 @default.
• W2054693521 hasAuthorship W2054693521A5051551818 @default.
• W2054693521 hasAuthorship W2054693521A5056890673 @default.
• W2054693521 hasAuthorship W2054693521A5087806461 @default.
• W2054693521 hasAuthorship W2054693521A5089364503 @default.
• W2054693521 hasAuthorship W2054693521A5091383588 @default.
• W2054693521 hasConcept C11960822 @default.
• W2054693521 hasConcept C126322002 @default.
• W2054693521 hasConcept C134018914 @default.
• W2054693521 hasConcept C158617107 @default.
• W2054693521 hasConcept C163415756 @default.
• W2054693521 hasConcept C17137333 @default.
• W2054693521 hasConcept C185592680 @default.
• W2054693521 hasConcept C207200792 @default.
• W2054693521 hasConcept C24998067 @default.
• W2054693521 hasConcept C2776805190 @default.
• W2054693521 hasConcept C2778198053 @default.
• W2054693521 hasConcept C55493867 @default.
• W2054693521 hasConcept C71924100 @default.
• W2054693521 hasConcept C97029542 @default.
• W2054693521 hasConceptScore W2054693521C11960822 @default.

• next