FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054697304> ?p ?o ?g. }

• W2054697304 abstract "Abstract Cellular responses to DNA damage involve distinct DNA repair pathways, such as mismatch repair (MMR) and base excision repair (BER). Using Caenorhabditis elegans as a model system, we present genetic and molecular evidence of a mechanistic link between processing of DNA damage and activation of autophagy. Here we show that the BER AP endonucleases APN-1 and EXO-3 function in the same pathway as MMR, to elicit DNA-directed toxicity in response to 5-fluorouracil, a mainstay of systemic adjuvant treatment of solid cancers. Immunohistochemical analyses suggest that EXO-3 generates the DNA nicks required for MMR activation. Processing of DNA damage via this pathway, in which both BER and MMR enzymes are required, leads to induction of autophagy in C. elegans and human cells. Hence, our data show that MMR- and AP endonuclease-dependent processing of 5-fluorouracil-induced DNA damage leads to checkpoint activation and induction of autophagy, whose hyperactivation contributes to cell death." @default.
• W2054697304 created "2016-06-24" @default.
• W2054697304 creator A5011432125 @default.
• W2054697304 creator A5029503476 @default.
• W2054697304 creator A5060469521 @default.
• W2054697304 creator A5073036493 @default.
• W2054697304 creator A5075477082 @default.
• W2054697304 creator A5077552949 @default.
• W2054697304 date "2013-10-24" @default.
• W2054697304 modified "2023-09-25" @default.
• W2054697304 title "Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy" @default.
• W2054697304 cites W1538501027 @default.
• W2054697304 cites W1970195025 @default.
• W2054697304 cites W1976385056 @default.
• W2054697304 cites W1980011868 @default.
• W2054697304 cites W1980373840 @default.
• W2054697304 cites W1984328540 @default.
• W2054697304 cites W1995642346 @default.
• W2054697304 cites W2000526989 @default.
• W2054697304 cites W2002472122 @default.
• W2054697304 cites W2010677667 @default.
• W2054697304 cites W2012076135 @default.
• W2054697304 cites W2020754075 @default.
• W2054697304 cites W2021776926 @default.
• W2054697304 cites W2023026626 @default.
• W2054697304 cites W2027385115 @default.
• W2054697304 cites W2037576550 @default.
• W2054697304 cites W2041916919 @default.
• W2054697304 cites W2045885851 @default.
• W2054697304 cites W2047383934 @default.
• W2054697304 cites W2057191753 @default.
• W2054697304 cites W2068668716 @default.
• W2054697304 cites W2070196548 @default.
• W2054697304 cites W2089667459 @default.
• W2054697304 cites W2093048712 @default.
• W2054697304 cites W2095581256 @default.
• W2054697304 cites W2114105734 @default.
• W2054697304 cites W2128275272 @default.
• W2054697304 cites W2140265233 @default.
• W2054697304 cites W2144375658 @default.
• W2054697304 cites W2163168572 @default.
• W2054697304 cites W4229677521 @default.
• W2054697304 cites W4240660831 @default.
• W2054697304 doi "https://doi.org/10.1038/ncomms3674" @default.
• W2054697304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3826653" @default.
• W2054697304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24154628" @default.
• W2054697304 hasPublicationYear "2013" @default.
• W2054697304 type Work @default.
• W2054697304 sameAs 2054697304 @default.
• W2054697304 citedByCount "53" @default.
• W2054697304 countsByYear W20546973042013 @default.
• W2054697304 countsByYear W20546973042014 @default.
• W2054697304 countsByYear W20546973042015 @default.
• W2054697304 countsByYear W20546973042016 @default.
• W2054697304 countsByYear W20546973042017 @default.
• W2054697304 countsByYear W20546973042018 @default.
• W2054697304 countsByYear W20546973042019 @default.
• W2054697304 countsByYear W20546973042020 @default.
• W2054697304 countsByYear W20546973042021 @default.
• W2054697304 countsByYear W20546973042022 @default.
• W2054697304 countsByYear W20546973042023 @default.
• W2054697304 crossrefType "journal-article" @default.
• W2054697304 hasAuthorship W2054697304A5011432125 @default.
• W2054697304 hasAuthorship W2054697304A5029503476 @default.
• W2054697304 hasAuthorship W2054697304A5060469521 @default.
• W2054697304 hasAuthorship W2054697304A5073036493 @default.
• W2054697304 hasAuthorship W2054697304A5075477082 @default.
• W2054697304 hasAuthorship W2054697304A5077552949 @default.
• W2054697304 hasBestOaLocation W20546973041 @default.
• W2054697304 hasConcept C104451858 @default.
• W2054697304 hasConcept C105696609 @default.
• W2054697304 hasConcept C134935766 @default.
• W2054697304 hasConcept C143425029 @default.
• W2054697304 hasConcept C1491633281 @default.
• W2054697304 hasConcept C153911025 @default.
• W2054697304 hasConcept C178169997 @default.
• W2054697304 hasConcept C187206112 @default.
• W2054697304 hasConcept C190283241 @default.
• W2054697304 hasConcept C203522944 @default.
• W2054697304 hasConcept C2777028655 @default.
• W2054697304 hasConcept C29537977 @default.
• W2054697304 hasConcept C50001416 @default.
• W2054697304 hasConcept C502942594 @default.
• W2054697304 hasConcept C54086632 @default.
• W2054697304 hasConcept C54355233 @default.
• W2054697304 hasConcept C552990157 @default.
• W2054697304 hasConcept C60748783 @default.
• W2054697304 hasConcept C86803240 @default.
• W2054697304 hasConcept C95444343 @default.
• W2054697304 hasConceptScore W2054697304C104451858 @default.
• W2054697304 hasConceptScore W2054697304C105696609 @default.
• W2054697304 hasConceptScore W2054697304C134935766 @default.
• W2054697304 hasConceptScore W2054697304C143425029 @default.
• W2054697304 hasConceptScore W2054697304C1491633281 @default.
• W2054697304 hasConceptScore W2054697304C153911025 @default.
• W2054697304 hasConceptScore W2054697304C178169997 @default.
• W2054697304 hasConceptScore W2054697304C187206112 @default.
• W2054697304 hasConceptScore W2054697304C190283241 @default.
• W2054697304 hasConceptScore W2054697304C203522944 @default.
• W2054697304 hasConceptScore W2054697304C2777028655 @default.

• next