Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054708657> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2054708657 endingPage "81" @default.
- W2054708657 startingPage "878" @default.
- W2054708657 abstract "Pustular vasculitis is a new disease concept that links cutaneous, and possibly systemic, aspects of Behçet's, bowel bypass, bowel-associated dermatosis-arthritis, and disseminated gonorrhea syndromes. The pathomechanism of pustular vasculitic lesion generation may relate to circulating immune complex (CIC)-mediated vessel damage and serum enhancement of neutrophil migration. Thalidomide, an oral pharmaceutical available on strict protocol, has therapeutic effects based on proposed modulation of CIC- and neutrophil-mediated cytotoxicity. Thalidomide therapy was started for four patients with significant morbidity from Behçet's syndrome and for one patient with bowel-associated dermatosis-arthritis syndrome. Clinical benefit was dramatic in all patients who completed sequential four-week on and off thalidomide therapeutic cycles. In three of four patients, in vivo testing for CIC after histamine injection immunopathology converted from positive (immunoreactant deposition in dermal vasculature [four hours after histamine] and CIC-mediated vasculitis [24 hours after histamine]) to negative during therapy. No effects were noted on neutrophil migration or on the LFA-1/Mac-1/p150,95 family of glycoproteins associated with neutrophil adherence as assessed qualitatively by tritium labelling of neutrophil cell surfaces. In this small patient group, thalidomide was a clinically effective, safe (with rigid monitoring) therapy whose mechanism of action may relate more to inhibitory effects on CIC-induced vasculitis than to effects on neutrophil-mediated cytotoxicity." @default.
- W2054708657 created "2016-06-24" @default.
- W2054708657 creator A5006979400 @default.
- W2054708657 creator A5015627032 @default.
- W2054708657 creator A5018911524 @default.
- W2054708657 creator A5041249577 @default.
- W2054708657 creator A5048041508 @default.
- W2054708657 creator A5077376432 @default.
- W2054708657 creator A5091227258 @default.
- W2054708657 creator A5091596168 @default.
- W2054708657 date "1986-05-01" @default.
- W2054708657 modified "2023-09-26" @default.
- W2054708657 title "Thalidomide effects in Behçet's syndrome and pustular vasculitis." @default.
- W2054708657 cites W1504600626 @default.
- W2054708657 cites W1578547237 @default.
- W2054708657 cites W1986103492 @default.
- W2054708657 cites W1994103391 @default.
- W2054708657 cites W2001158523 @default.
- W2054708657 cites W2012441494 @default.
- W2054708657 cites W2026455708 @default.
- W2054708657 cites W2027555684 @default.
- W2054708657 cites W2050499267 @default.
- W2054708657 cites W2067211425 @default.
- W2054708657 cites W2090732962 @default.
- W2054708657 cites W2091833120 @default.
- W2054708657 cites W2099160500 @default.
- W2054708657 cites W2126237672 @default.
- W2054708657 cites W2138671432 @default.
- W2054708657 cites W2416249746 @default.
- W2054708657 cites W2463397481 @default.
- W2054708657 cites W2402464195 @default.
- W2054708657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3963978" @default.
- W2054708657 hasPublicationYear "1986" @default.
- W2054708657 type Work @default.
- W2054708657 sameAs 2054708657 @default.
- W2054708657 citedByCount "28" @default.
- W2054708657 countsByYear W20547086572012 @default.
- W2054708657 countsByYear W20547086572013 @default.
- W2054708657 countsByYear W20547086572014 @default.
- W2054708657 countsByYear W20547086572015 @default.
- W2054708657 crossrefType "journal-article" @default.
- W2054708657 hasAuthorship W2054708657A5006979400 @default.
- W2054708657 hasAuthorship W2054708657A5015627032 @default.
- W2054708657 hasAuthorship W2054708657A5018911524 @default.
- W2054708657 hasAuthorship W2054708657A5041249577 @default.
- W2054708657 hasAuthorship W2054708657A5048041508 @default.
- W2054708657 hasAuthorship W2054708657A5077376432 @default.
- W2054708657 hasAuthorship W2054708657A5091227258 @default.
- W2054708657 hasAuthorship W2054708657A5091596168 @default.
- W2054708657 hasConcept C126322002 @default.
- W2054708657 hasConcept C203014093 @default.
- W2054708657 hasConcept C2776015282 @default.
- W2054708657 hasConcept C2776364478 @default.
- W2054708657 hasConcept C2777374719 @default.
- W2054708657 hasConcept C2779134260 @default.
- W2054708657 hasConcept C2779609412 @default.
- W2054708657 hasConcept C71924100 @default.
- W2054708657 hasConceptScore W2054708657C126322002 @default.
- W2054708657 hasConceptScore W2054708657C203014093 @default.
- W2054708657 hasConceptScore W2054708657C2776015282 @default.
- W2054708657 hasConceptScore W2054708657C2776364478 @default.
- W2054708657 hasConceptScore W2054708657C2777374719 @default.
- W2054708657 hasConceptScore W2054708657C2779134260 @default.
- W2054708657 hasConceptScore W2054708657C2779609412 @default.
- W2054708657 hasConceptScore W2054708657C71924100 @default.
- W2054708657 hasIssue "5" @default.
- W2054708657 hasLocation W20547086571 @default.
- W2054708657 hasOpenAccess W2054708657 @default.
- W2054708657 hasPrimaryLocation W20547086571 @default.
- W2054708657 hasRelatedWork W1504812391 @default.
- W2054708657 hasRelatedWork W1999635097 @default.
- W2054708657 hasRelatedWork W2020433352 @default.
- W2054708657 hasRelatedWork W2031391748 @default.
- W2054708657 hasRelatedWork W2103732916 @default.
- W2054708657 hasRelatedWork W2110992334 @default.
- W2054708657 hasRelatedWork W2588771428 @default.
- W2054708657 hasRelatedWork W3105506351 @default.
- W2054708657 hasRelatedWork W3156071913 @default.
- W2054708657 hasRelatedWork W4256241780 @default.
- W2054708657 hasVolume "146" @default.
- W2054708657 isParatext "false" @default.
- W2054708657 isRetracted "false" @default.
- W2054708657 magId "2054708657" @default.
- W2054708657 workType "article" @default.