FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054710060> ?p ?o ?g. }

• W2054710060 endingPage "2796" @default.
• W2054710060 startingPage "2785" @default.
• W2054710060 abstract "Antitumor nitrogen mustards, such as bis(2-chloroethyl)methylamine (mechlorethamine), are useful chemotherapeutic agents with a long history of clinical application. The antitumor effects of nitrogen mustards are attributed to their ability to induce DNA–DNA and DNA–protein cross-links (DPCs) that block DNA replication. In the present work, a mass spectrometry-based methodology was employed to characterize in vivo DNA–protein cross-linking following treatment of human fibrosarcoma (HT1080) cells with cytotoxic concentrations of mechlorethamine. A combination of mass spectrometry-based proteomics and immunological detection was used to identify 38 nuclear proteins that were covalently cross-linked to chromosomal DNA following treatment with mechlorethamine. Isotope dilution HPLC–ESI+–MS/MS analysis of total proteolytic digests revealed a concentration-dependent formation of N-[2-(S-cysteinyl)ethyl]-N-[2-(guan-7-yl)ethyl]methylamine (Cys-N7G-EMA) conjugates, indicating that mechlorethamine cross-links cysteine thiols within proteins to N-7 positions of guanine in DNA." @default.
• W2054710060 created "2016-06-24" @default.
• W2054710060 creator A5018738469 @default.
• W2054710060 creator A5023147767 @default.
• W2054710060 creator A5034621530 @default.
• W2054710060 creator A5068509910 @default.
• W2054710060 creator A5070957190 @default.
• W2054710060 creator A5076297382 @default.
• W2054710060 creator A5090360405 @default.
• W2054710060 date "2011-04-29" @default.
• W2054710060 modified "2023-10-02" @default.
• W2054710060 title "Mechlorethamine-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells" @default.
• W2054710060 cites W1967042727 @default.
• W2054710060 cites W1967762868 @default.
• W2054710060 cites W1968240894 @default.
• W2054710060 cites W1976857186 @default.
• W2054710060 cites W1981982904 @default.
• W2054710060 cites W1990273811 @default.
• W2054710060 cites W1994053770 @default.
• W2054710060 cites W1998381543 @default.
• W2054710060 cites W1998969339 @default.
• W2054710060 cites W2003104691 @default.
• W2054710060 cites W2011347367 @default.
• W2054710060 cites W2026215061 @default.
• W2054710060 cites W2030350544 @default.
• W2054710060 cites W2034552316 @default.
• W2054710060 cites W2041106507 @default.
• W2054710060 cites W2045308363 @default.
• W2054710060 cites W2045340640 @default.
• W2054710060 cites W2068519290 @default.
• W2054710060 cites W2069680779 @default.
• W2054710060 cites W2077389084 @default.
• W2054710060 cites W2080144605 @default.
• W2054710060 cites W2084089214 @default.
• W2054710060 cites W2086260870 @default.
• W2054710060 cites W2091477263 @default.
• W2054710060 cites W2103081500 @default.
• W2054710060 cites W2115028540 @default.
• W2054710060 cites W2122412289 @default.
• W2054710060 cites W2127568626 @default.
• W2054710060 cites W2131105369 @default.
• W2054710060 cites W2952670656 @default.
• W2054710060 cites W4248361105 @default.
• W2054710060 doi "https://doi.org/10.1021/pr200042u" @default.
• W2054710060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3208907" @default.
• W2054710060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21486066" @default.
• W2054710060 hasPublicationYear "2011" @default.
• W2054710060 type Work @default.
• W2054710060 sameAs 2054710060 @default.
• W2054710060 citedByCount "51" @default.
• W2054710060 countsByYear W20547100602012 @default.
• W2054710060 countsByYear W20547100602013 @default.
• W2054710060 countsByYear W20547100602014 @default.
• W2054710060 countsByYear W20547100602015 @default.
• W2054710060 countsByYear W20547100602016 @default.
• W2054710060 countsByYear W20547100602017 @default.
• W2054710060 countsByYear W20547100602018 @default.
• W2054710060 countsByYear W20547100602019 @default.
• W2054710060 countsByYear W20547100602020 @default.
• W2054710060 countsByYear W20547100602021 @default.
• W2054710060 countsByYear W20547100602022 @default.
• W2054710060 countsByYear W20547100602023 @default.
• W2054710060 crossrefType "journal-article" @default.
• W2054710060 hasAuthorship W2054710060A5018738469 @default.
• W2054710060 hasAuthorship W2054710060A5023147767 @default.
• W2054710060 hasAuthorship W2054710060A5034621530 @default.
• W2054710060 hasAuthorship W2054710060A5068509910 @default.
• W2054710060 hasAuthorship W2054710060A5070957190 @default.
• W2054710060 hasAuthorship W2054710060A5076297382 @default.
• W2054710060 hasAuthorship W2054710060A5090360405 @default.
• W2054710060 hasBestOaLocation W20547100602 @default.
• W2054710060 hasConcept C104317684 @default.
• W2054710060 hasConcept C143425029 @default.
• W2054710060 hasConcept C153911025 @default.
• W2054710060 hasConcept C185592680 @default.
• W2054710060 hasConcept C202751555 @default.
• W2054710060 hasConcept C2776694085 @default.
• W2054710060 hasConcept C2776755627 @default.
• W2054710060 hasConcept C2777751087 @default.
• W2054710060 hasConcept C2778301229 @default.
• W2054710060 hasConcept C2778670039 @default.
• W2054710060 hasConcept C2778969155 @default.
• W2054710060 hasConcept C512185932 @default.
• W2054710060 hasConcept C54355233 @default.
• W2054710060 hasConcept C552990157 @default.
• W2054710060 hasConcept C55493867 @default.
• W2054710060 hasConcept C86803240 @default.
• W2054710060 hasConceptScore W2054710060C104317684 @default.
• W2054710060 hasConceptScore W2054710060C143425029 @default.
• W2054710060 hasConceptScore W2054710060C153911025 @default.
• W2054710060 hasConceptScore W2054710060C185592680 @default.
• W2054710060 hasConceptScore W2054710060C202751555 @default.
• W2054710060 hasConceptScore W2054710060C2776694085 @default.
• W2054710060 hasConceptScore W2054710060C2776755627 @default.
• W2054710060 hasConceptScore W2054710060C2777751087 @default.
• W2054710060 hasConceptScore W2054710060C2778301229 @default.
• W2054710060 hasConceptScore W2054710060C2778670039 @default.
• W2054710060 hasConceptScore W2054710060C2778969155 @default.

• next