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• W2054726131 abstract "Cryptophycins are cytotoxic natural products that exhibit considerable activities even against multi-drug-resistant tumor cell lines. As fluorinated pharmaceuticals have become more and more important during the past decades, fluorine-functionalized cryptophycins were synthesized and evaluated in cell-based cytotoxicity assays. The unit A trifluoromethyl-modified cryptophycin proved to be highly active against KB-3-1 cells and exhibited an IC 50 value in the low picomolar range. However, the replacement of the 3-chloro-4-methoxyphenyl-substituent in unit B by a pentafluorophenyl moiety resulted in a significant loss of activity." @default.
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• W2054726131 date "2012-11-23" @default.
• W2054726131 modified "2023-09-27" @default.
• W2054726131 title "Total synthesis and biological evaluation of fluorinated cryptophycins" @default.
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• W2054726131 doi "https://doi.org/10.3762/bjoc.8.231" @default.
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