Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054740999> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2054740999 endingPage "S272" @default.
- W2054740999 startingPage "S271" @default.
- W2054740999 abstract "Neurodevelopmental disorders including Tourette’s syndrome (TS) and attention deficit hyperactivity disorder (ADHD) are characterized by significant impairment in attention and cognitive control. These cognitive deficits persist throughout development, contribute significantly to socio-occupational impairment, and are relatively impervious to available treatment. A critical challenge in pro-cognitive drug discovery is translatability of findings across species, underscoring the need for developing valid and reliable cross-species cognitive tasks.Here we describe a cross-species 5 choice continuous performance task that was developed to measure cognitive control processes of attention, vigilance, and response inhibition, enabling the translation of findings for pro-cognitive drug discovery across species and delineate neural mechanisms underlying cognitive control construct.Construct validity of 5C-CPT has been verified by multiple cross-species studies. Several lines of evidence report consistent findings across species including, deficits resulting from 36-h sleep deprivation studies, engagement of parietal cortex in human brain imaging and rodent lesion studies, and vigilance decrements over time.: Unlike the widely used rodent 5 choice serial reaction time task (5CSRTT) and the sustained attention task (SAT), the rodent 5C-CPT includes both target and non-target stimuli that allow measuring of cognitive control elements including response inhibition, an ability to inhibit pre-potent response during non-target trials, detect vigilance decrement and calculate signal detection parameters in rodents analogous to human CPT.The cross-species 5C-CPT is a robust translational tool to characterize the neurobiological substrates underlying cognitive control deficits in clinical population including, ADHD and TS and develop targeted pro-cognitive therapeutics." @default.
- W2054740999 created "2016-06-24" @default.
- W2054740999 creator A5001991121 @default.
- W2054740999 creator A5052429054 @default.
- W2054740999 creator A5058095179 @default.
- W2054740999 creator A5071912321 @default.
- W2054740999 date "2014-04-01" @default.
- W2054740999 modified "2023-10-18" @default.
- W2054740999 title "Poster #M225 AMISULPIRIDE FOR ELDERLY PATIENTS WITH CHRONIC SCHIZOPHRENIA" @default.
- W2054740999 doi "https://doi.org/10.1016/s0920-9964(14)70775-3" @default.
- W2054740999 hasPublicationYear "2014" @default.
- W2054740999 type Work @default.
- W2054740999 sameAs 2054740999 @default.
- W2054740999 citedByCount "0" @default.
- W2054740999 crossrefType "journal-article" @default.
- W2054740999 hasAuthorship W2054740999A5001991121 @default.
- W2054740999 hasAuthorship W2054740999A5052429054 @default.
- W2054740999 hasAuthorship W2054740999A5058095179 @default.
- W2054740999 hasAuthorship W2054740999A5071912321 @default.
- W2054740999 hasConcept C126139899 @default.
- W2054740999 hasConcept C15744967 @default.
- W2054740999 hasConcept C169760540 @default.
- W2054740999 hasConcept C169900460 @default.
- W2054740999 hasConcept C180747234 @default.
- W2054740999 hasConcept C192769605 @default.
- W2054740999 hasConcept C2777745069 @default.
- W2054740999 hasConcept C2781114239 @default.
- W2054740999 hasConcept C2908647359 @default.
- W2054740999 hasConcept C71924100 @default.
- W2054740999 hasConcept C99454951 @default.
- W2054740999 hasConceptScore W2054740999C126139899 @default.
- W2054740999 hasConceptScore W2054740999C15744967 @default.
- W2054740999 hasConceptScore W2054740999C169760540 @default.
- W2054740999 hasConceptScore W2054740999C169900460 @default.
- W2054740999 hasConceptScore W2054740999C180747234 @default.
- W2054740999 hasConceptScore W2054740999C192769605 @default.
- W2054740999 hasConceptScore W2054740999C2777745069 @default.
- W2054740999 hasConceptScore W2054740999C2781114239 @default.
- W2054740999 hasConceptScore W2054740999C2908647359 @default.
- W2054740999 hasConceptScore W2054740999C71924100 @default.
- W2054740999 hasConceptScore W2054740999C99454951 @default.
- W2054740999 hasLocation W20547409991 @default.
- W2054740999 hasOpenAccess W2054740999 @default.
- W2054740999 hasPrimaryLocation W20547409991 @default.
- W2054740999 hasRelatedWork W1969917653 @default.
- W2054740999 hasRelatedWork W1999974019 @default.
- W2054740999 hasRelatedWork W2051831694 @default.
- W2054740999 hasRelatedWork W2079468847 @default.
- W2054740999 hasRelatedWork W2100527336 @default.
- W2054740999 hasRelatedWork W2738157816 @default.
- W2054740999 hasRelatedWork W2893496646 @default.
- W2054740999 hasRelatedWork W2912201061 @default.
- W2054740999 hasRelatedWork W4252300353 @default.
- W2054740999 hasRelatedWork W4253043443 @default.
- W2054740999 hasVolume "153" @default.
- W2054740999 isParatext "false" @default.
- W2054740999 isRetracted "false" @default.
- W2054740999 magId "2054740999" @default.
- W2054740999 workType "article" @default.