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• W2054742008 abstract "We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II andL-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane and artificially ventilated. Responses of mean arterial pressure (MAP), heart rate (HR) and splanchnic sympathetic nerve activity (SNA) to microinjection of Ang II (100 pmol) orL-Glu (2 nmol) into the RVLM were examined following microinjection of losartan (10 pmol–10 nmol). Ang II increased MAP (16 ± 1mmHg in SHR and16 ± 1mmHg in WKY) and SNA (9 ± 1%and10 ± 1%, respectively), which were significantly (P < 0.01) attenuated by pretreatment with losartan (100 pmol − 10 nmol) in both strains. In addition, the pressor and sympathoexcitatory responses evoked byL-Glu were attenuated by losartan in a dose-dependent manner. The increases of MAP evoked byL-Glu (53 ± 6mmHg in SHR and39 ± 3mmHg in WKY) were suppressed to 5 ± 3mmHg(P < 0.01) and 4 ± 2mmHg (P < 0.01), respectively, in the presence of 10 nmol of losartan. The increase of SNA was also markedly inhibited by higher doses of losartan. The cardiovascular responses evoked byL-Glu, however, were not attenuated by pretreatment with either 1 nmol of [Sar1, Thr8]-Ang II or 10 nmol of potassium acetate, suggesting that the effect of losartan onL-Glu response may not be attributed to the blockade of Ang II receptor or to the high concentration of potassium. These results indicate that the AT1 receptor is responsible, in part, for the vasomotor action of Ang II in the RVLM and losartan has an inhibitory effect on pressor and sympathoexcitatory responses evoked byL-Glu by mechanisms other than those mediated by Ang II receptors." @default.
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• W2054742008 date "1994-12-01" @default.
• W2054742008 modified "2023-09-24" @default.
• W2054742008 title "Losartan, nonpeptide angiotensin II-type 1 (AT1) receptor antagonist, attenuates pressor and sympathoexcitatory responses evoked by angiotensin II andL-glutamate in rostral ventrolateral medulla" @default.
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• W2054742008 doi "https://doi.org/10.1016/0006-8993(94)91344-7" @default.
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