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• W2054753693 endingPage "2756" @default.
• W2054753693 startingPage "2756" @default.
• W2054753693 abstract "We have developed aptamer (Apt)-conjugated gold nanoparticles (Apt-Au NPs, 13 nm in diameter) as highly effective inhibitors for human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). Two Apts, RT1t49 (Aptpol) and ODN 93 (AptRH), which recognize the polymerase and RNase H regions of HIV-1 RT, are used to conjugate Au NPs to prepare Aptpol-Au NPs and AptRH-Au NPs, respectively. In addition to DNA sequence, the surface density of the aptamers on Au NPs (nApt-Au NPs; n is the number of aptamer molecules on each Au NP) and the linker length number (Tm; m is the base number of the deoxythymidine linker) between the aptamer and Au NPs play important roles in determining their inhibition activity. A HIV-lentiviral vector-based antiviral assay has been applied to determine the inhibitory effect of aptamers or Apt-Au NPs on the early stages of their replication cycle. The nuclease-stable G-quadruplex structure of 40AptRH-T45-Au NPs shows inhibitory efficiency in the retroviral replication cycle with a decreasing infectivity (40.2%)." @default.
• W2054753693 created "2016-06-24" @default.
• W2054753693 creator A5009719171 @default.
• W2054753693 creator A5011795671 @default.
• W2054753693 creator A5027648653 @default.
• W2054753693 creator A5035315375 @default.
• W2054753693 creator A5040369687 @default.
• W2054753693 creator A5054377218 @default.
• W2054753693 creator A5083622437 @default.
• W2054753693 date "2013-01-01" @default.
• W2054753693 modified "2023-09-26" @default.
• W2054753693 title "Highly efficient inhibition of human immunodeficiency virus type 1 reverse transcriptase by aptamers functionalized gold nanoparticles" @default.
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