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- W2054757941 abstract "There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and alpha-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drugs in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, alpha-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat." @default.
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- W2054757941 date "1999-03-01" @default.
- W2054757941 modified "2023-10-14" @default.
- W2054757941 title "Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat" @default.
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- W2054757941 doi "https://doi.org/10.1016/s0024-3205(99)00097-1" @default.
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