Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054758465> ?p ?o ?g. }
- W2054758465 endingPage "320" @default.
- W2054758465 startingPage "307" @default.
- W2054758465 abstract "Development of nervous tissue is controlled, in part, by the ornithine decarboxylase (ODC)/polyamine system. Each brain region possesses a unique ontogenetic pattern for ODC, with highest levels of the enzyme associated with periods of most rapid growth. For this reason, perturbation of the ODC profile has proven useful in examinations of tératologic mechanisms and detection of adverse environmental effects during development. More recently, the replication of neuronal cells in developing brain has been shown to require the maintenance of polyamine levels and consequently, depletion of polyamines by α-difluoromethylornithine (DFMO, an ODC inhibitor) arrests brain cell maturation. DFMO also interferes with neuronal migration, axonogenesis and synaptogenesis, leading to disruption of the cytoarchitectural organization of brain structures: these results imply a similarly important role for polyamines in post-replicative events. Indeed, [3HDFMO-autoradiographic localization of ODC in developing cerebellar lamina indicates high levels of activity associated with neuropil, areas of axonal outgrowth, and post-mitotic granule cells. Axonal outgrowth during regeneration after nerve damage in the mature nervous system may display some of the same characteristics as in developing neurons, suggesting that the two processes share common polyamine-dependent mechanisms." @default.
- W2054758465 created "2016-06-24" @default.
- W2054758465 creator A5000464378 @default.
- W2054758465 creator A5000479309 @default.
- W2054758465 date "1986-09-01" @default.
- W2054758465 modified "2023-09-25" @default.
- W2054758465 title "Role of ornithine decarboxylase and the polyamines in nervous system development: A review" @default.
- W2054758465 cites W1431583205 @default.
- W2054758465 cites W1484324329 @default.
- W2054758465 cites W1783564941 @default.
- W2054758465 cites W1966288743 @default.
- W2054758465 cites W1967285990 @default.
- W2054758465 cites W1972549118 @default.
- W2054758465 cites W1983297489 @default.
- W2054758465 cites W1985723171 @default.
- W2054758465 cites W1992355696 @default.
- W2054758465 cites W1992698235 @default.
- W2054758465 cites W1993754203 @default.
- W2054758465 cites W2000057578 @default.
- W2054758465 cites W2000975041 @default.
- W2054758465 cites W2002550631 @default.
- W2054758465 cites W2005652086 @default.
- W2054758465 cites W2007566657 @default.
- W2054758465 cites W2011210622 @default.
- W2054758465 cites W2014132400 @default.
- W2054758465 cites W2015128969 @default.
- W2054758465 cites W2015456882 @default.
- W2054758465 cites W2016288213 @default.
- W2054758465 cites W2023762115 @default.
- W2054758465 cites W2026131799 @default.
- W2054758465 cites W2027068706 @default.
- W2054758465 cites W2027121293 @default.
- W2054758465 cites W2028899528 @default.
- W2054758465 cites W2032331020 @default.
- W2054758465 cites W2032541890 @default.
- W2054758465 cites W2040230882 @default.
- W2054758465 cites W2041556838 @default.
- W2054758465 cites W2042049928 @default.
- W2054758465 cites W2043985253 @default.
- W2054758465 cites W2050949458 @default.
- W2054758465 cites W2052715447 @default.
- W2054758465 cites W2059468057 @default.
- W2054758465 cites W2074867502 @default.
- W2054758465 cites W2078772096 @default.
- W2054758465 cites W2083079475 @default.
- W2054758465 cites W2089562998 @default.
- W2054758465 cites W2090740653 @default.
- W2054758465 cites W2103915948 @default.
- W2054758465 cites W2114246851 @default.
- W2054758465 cites W2127952009 @default.
- W2054758465 cites W2137799116 @default.
- W2054758465 cites W2143836655 @default.
- W2054758465 cites W2153259404 @default.
- W2054758465 cites W2158519590 @default.
- W2054758465 cites W2160557040 @default.
- W2054758465 cites W2230656713 @default.
- W2054758465 cites W4230194448 @default.
- W2054758465 cites W4323966420 @default.
- W2054758465 doi "https://doi.org/10.1016/0361-9230(86)90236-4" @default.
- W2054758465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3094839" @default.
- W2054758465 hasPublicationYear "1986" @default.
- W2054758465 type Work @default.
- W2054758465 sameAs 2054758465 @default.
- W2054758465 citedByCount "231" @default.
- W2054758465 countsByYear W20547584652012 @default.
- W2054758465 countsByYear W20547584652013 @default.
- W2054758465 countsByYear W20547584652014 @default.
- W2054758465 countsByYear W20547584652015 @default.
- W2054758465 countsByYear W20547584652016 @default.
- W2054758465 countsByYear W20547584652017 @default.
- W2054758465 countsByYear W20547584652018 @default.
- W2054758465 countsByYear W20547584652020 @default.
- W2054758465 countsByYear W20547584652021 @default.
- W2054758465 countsByYear W20547584652022 @default.
- W2054758465 countsByYear W20547584652023 @default.
- W2054758465 crossrefType "journal-article" @default.
- W2054758465 hasAuthorship W2054758465A5000464378 @default.
- W2054758465 hasAuthorship W2054758465A5000479309 @default.
- W2054758465 hasConcept C121289238 @default.
- W2054758465 hasConcept C169760540 @default.
- W2054758465 hasConcept C181199279 @default.
- W2054758465 hasConcept C2777497464 @default.
- W2054758465 hasConcept C2777831001 @default.
- W2054758465 hasConcept C2780115381 @default.
- W2054758465 hasConcept C529278444 @default.
- W2054758465 hasConcept C545706735 @default.
- W2054758465 hasConcept C55493867 @default.
- W2054758465 hasConcept C65232495 @default.
- W2054758465 hasConcept C86803240 @default.
- W2054758465 hasConcept C95444343 @default.
- W2054758465 hasConceptScore W2054758465C121289238 @default.
- W2054758465 hasConceptScore W2054758465C169760540 @default.
- W2054758465 hasConceptScore W2054758465C181199279 @default.
- W2054758465 hasConceptScore W2054758465C2777497464 @default.
- W2054758465 hasConceptScore W2054758465C2777831001 @default.
- W2054758465 hasConceptScore W2054758465C2780115381 @default.
- W2054758465 hasConceptScore W2054758465C529278444 @default.
- W2054758465 hasConceptScore W2054758465C545706735 @default.