FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054793128> ?p ?o ?g. }

• W2054793128 endingPage "4828" @default.
• W2054793128 startingPage "4819" @default.
• W2054793128 abstract "Lamins A and C are intermediate filament proteins which polymerize into the nucleus to form the nuclear lamina network. The lamina is apposed to the inner nuclear membrane and functions in tethering chromatin to the nuclear envelope and in maintaining nuclear shape. We have recently characterized a globular domain that adopts an immunoglobulin fold in the carboxyl-terminal tail common to lamins A and C. Using an electrophoretic mobility shift assay (EMSA), we show that a peptide containing this domain interacts in vitro with DNA after dimerization through a disulfide bond, but does not interact with the core particle or the dinucleosome. The covalent dimer binds a 30-40 bp DNA fragment with a micromolar affinity and no sequence specificity. Using nuclear magnetic resonance (NMR) and an EMSA, we observed that two peptide regions participate in the DNA binding: the unstructured amino-terminal part containing the nuclear localization signal and a large positively charged region centered around amino acid R482 at the surface of the immunoglobulin-like domain. Mutations R482Q and -W, which are responsible for Dunnigan-type partial lipodystrophy, lower the affinity of the peptide for DNA. We conclude that the carboxyl-terminal end of lamins A and C binds DNA and suggest that alterations in lamin-DNA interactions may play a role in the pathophysiology of some lamin-linked diseases." @default.
• W2054793128 created "2016-06-24" @default.
• W2054793128 creator A5008842884 @default.
• W2054793128 creator A5018195802 @default.
• W2054793128 creator A5034559960 @default.
• W2054793128 creator A5036871086 @default.
• W2054793128 creator A5037581308 @default.
• W2054793128 creator A5061987054 @default.
• W2054793128 creator A5071188846 @default.
• W2054793128 creator A5072994078 @default.
• W2054793128 creator A5074593255 @default.
• W2054793128 date "2003-04-09" @default.
• W2054793128 modified "2023-10-11" @default.
• W2054793128 title "The Carboxyl-Terminal Region Common to Lamins A and C Contains a DNA Binding Domain" @default.
• W2054793128 cites W1479884475 @default.
• W2054793128 cites W1540833582 @default.
• W2054793128 cites W1607739244 @default.
• W2054793128 cites W1930356963 @default.
• W2054793128 cites W1931189484 @default.
• W2054793128 cites W1934956719 @default.
• W2054793128 cites W1966118867 @default.
• W2054793128 cites W1985092753 @default.
• W2054793128 cites W2004084057 @default.
• W2054793128 cites W2009407579 @default.
• W2054793128 cites W2044920966 @default.
• W2054793128 cites W2066501944 @default.
• W2054793128 cites W2088990291 @default.
• W2054793128 cites W2104140002 @default.
• W2054793128 cites W2122131642 @default.
• W2054793128 cites W2122412289 @default.
• W2054793128 cites W2131057753 @default.
• W2054793128 cites W2169821755 @default.
• W2054793128 cites W2175346537 @default.
• W2054793128 doi "https://doi.org/10.1021/bi020704g" @default.
• W2054793128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12718522" @default.
• W2054793128 hasPublicationYear "2003" @default.
• W2054793128 type Work @default.
• W2054793128 sameAs 2054793128 @default.
• W2054793128 citedByCount "168" @default.
• W2054793128 countsByYear W20547931282012 @default.
• W2054793128 countsByYear W20547931282013 @default.
• W2054793128 countsByYear W20547931282014 @default.
• W2054793128 countsByYear W20547931282015 @default.
• W2054793128 countsByYear W20547931282016 @default.
• W2054793128 countsByYear W20547931282017 @default.
• W2054793128 countsByYear W20547931282018 @default.
• W2054793128 countsByYear W20547931282019 @default.
• W2054793128 countsByYear W20547931282020 @default.
• W2054793128 countsByYear W20547931282021 @default.
• W2054793128 countsByYear W20547931282022 @default.
• W2054793128 countsByYear W20547931282023 @default.
• W2054793128 crossrefType "journal-article" @default.
• W2054793128 hasAuthorship W2054793128A5008842884 @default.
• W2054793128 hasAuthorship W2054793128A5018195802 @default.
• W2054793128 hasAuthorship W2054793128A5034559960 @default.
• W2054793128 hasAuthorship W2054793128A5036871086 @default.
• W2054793128 hasAuthorship W2054793128A5037581308 @default.
• W2054793128 hasAuthorship W2054793128A5061987054 @default.
• W2054793128 hasAuthorship W2054793128A5071188846 @default.
• W2054793128 hasAuthorship W2054793128A5072994078 @default.
• W2054793128 hasAuthorship W2054793128A5074593255 @default.
• W2054793128 hasConcept C104317684 @default.
• W2054793128 hasConcept C12554922 @default.
• W2054793128 hasConcept C153911025 @default.
• W2054793128 hasConcept C179093185 @default.
• W2054793128 hasConcept C185592680 @default.
• W2054793128 hasConcept C29512474 @default.
• W2054793128 hasConcept C33987129 @default.
• W2054793128 hasConcept C552990157 @default.
• W2054793128 hasConcept C55493867 @default.
• W2054793128 hasConcept C83640560 @default.
• W2054793128 hasConcept C86339819 @default.
• W2054793128 hasConcept C86803240 @default.
• W2054793128 hasConcept C94912109 @default.
• W2054793128 hasConcept C95444343 @default.
• W2054793128 hasConceptScore W2054793128C104317684 @default.
• W2054793128 hasConceptScore W2054793128C12554922 @default.
• W2054793128 hasConceptScore W2054793128C153911025 @default.
• W2054793128 hasConceptScore W2054793128C179093185 @default.
• W2054793128 hasConceptScore W2054793128C185592680 @default.
• W2054793128 hasConceptScore W2054793128C29512474 @default.
• W2054793128 hasConceptScore W2054793128C33987129 @default.
• W2054793128 hasConceptScore W2054793128C552990157 @default.
• W2054793128 hasConceptScore W2054793128C55493867 @default.
• W2054793128 hasConceptScore W2054793128C83640560 @default.
• W2054793128 hasConceptScore W2054793128C86339819 @default.
• W2054793128 hasConceptScore W2054793128C86803240 @default.
• W2054793128 hasConceptScore W2054793128C94912109 @default.
• W2054793128 hasConceptScore W2054793128C95444343 @default.
• W2054793128 hasIssue "17" @default.
• W2054793128 hasLocation W20547931281 @default.
• W2054793128 hasLocation W20547931282 @default.
• W2054793128 hasOpenAccess W2054793128 @default.
• W2054793128 hasPrimaryLocation W20547931281 @default.
• W2054793128 hasRelatedWork W1971934332 @default.
• W2054793128 hasRelatedWork W1972070097 @default.
• W2054793128 hasRelatedWork W2043006129 @default.
• W2054793128 hasRelatedWork W2065776621 @default.

• next