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- W2054794512 abstract "Thymidine kinaseless L murine cells infected with ultraviolet-irradiated herpes simplex virus produce clones which contain a thymidine kinase activity not found in the parental thymidine kinaseless L cell line. One of these clones (no. 139) has been analyzed for the presence of the virus genome. Reassociation kinetic analyses using iodinated virus DNA have established that there are approximately five copies of a fragment comprising about 23% of the virus genome in each clone 139 cell. Neither the parental thymidine kinaseless L cell line nor a “revertant” cell line obtained from clone 139 showed any detectable virus DNA specific sequences. These results suggest that the thymidine kinase activity is probably encoded by a fragment of the viral genome integrated in the DNA of, or carried by, the clone 139 cells." @default.
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- W2054794512 date "1975-10-01" @default.
- W2054794512 modified "2023-09-26" @default.
- W2054794512 title "Presence of a herpes simplex virus DNA fragment in an L cell clone obtained after infection with irradiated herpes simplex virus 1" @default.
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- W2054794512 doi "https://doi.org/10.1016/s0022-2836(75)80057-x" @default.
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