Matches in SemOpenAlex for { <https://semopenalex.org/work/W20548> ?p ?o ?g. }
- W20548 endingPage "207" @default.
- W20548 startingPage "192" @default.
- W20548 abstract "During Pregnancy, heart develops physiological left ventricular hypertrophy as a result of the natural volume overload. Previously we have characterized the molecular and functional signature of heart hypertrophy during pregnancy. Cardiac hypertrophy during pregnancy is a complex process that involves many changes including in the signalling pathways, composition of extracellular matrix as well as the levels of sex hormones. This review summarises the recent advances and the new frontiers in the context of heart hypertrophy during pregnancy. In particular we focus on structural and extracellular matrix remodelling as well as signalling pathways in pregnancy-induced physiological heart hypertrophy. Emerging evidence shows that various microRNAs modulate key components of hypertrophy, therefore the role of microRNAs in the regulation of gene expression in pregnancy induced hypertrophy is also discussed. We also review the role of ubiquitin proteasome system, the major machinery for the degradation of damaged and misfolded proteins, in heart hypertrophy. The role of sex hormones in particular estrogen in cardiac remodeling during pregnancy is also discussed. We also review pregnancy-induced cardiovascular complications such as peripartum cardiomyopathy and pre-eclampsia and how the knowledge from the animal studies may help us to develop new therapeutic strategies for better treatment of cardiovascular diseases during pregnancy. Special emphasis has to be given to the guidelines on disease management in pregnancy." @default.
- W20548 created "2016-06-24" @default.
- W20548 creator A5014409491 @default.
- W20548 creator A5016874335 @default.
- W20548 creator A5030902395 @default.
- W20548 creator A5031157503 @default.
- W20548 creator A5049788059 @default.
- W20548 creator A5057574658 @default.
- W20548 creator A5069267909 @default.
- W20548 creator A5075565751 @default.
- W20548 date "2012-01-01" @default.
- W20548 modified "2023-10-05" @default.
- W20548 title "New frontiers in heart hypertrophy during pregnancy." @default.
- W20548 cites W117494188 @default.
- W20548 cites W1482473767 @default.
- W20548 cites W1490850016 @default.
- W20548 cites W1574653524 @default.
- W20548 cites W1583802054 @default.
- W20548 cites W1584433563 @default.
- W20548 cites W1590398744 @default.
- W20548 cites W1601324252 @default.
- W20548 cites W1643693347 @default.
- W20548 cites W17046333 @default.
- W20548 cites W1786115289 @default.
- W20548 cites W1889002087 @default.
- W20548 cites W1913007537 @default.
- W20548 cites W1920303762 @default.
- W20548 cites W1967455462 @default.
- W20548 cites W1973030441 @default.
- W20548 cites W1974266173 @default.
- W20548 cites W1974643351 @default.
- W20548 cites W1977618635 @default.
- W20548 cites W1981607156 @default.
- W20548 cites W1981995092 @default.
- W20548 cites W1982611296 @default.
- W20548 cites W1982922130 @default.
- W20548 cites W1984538103 @default.
- W20548 cites W1986421392 @default.
- W20548 cites W1988330512 @default.
- W20548 cites W1990780004 @default.
- W20548 cites W1991447679 @default.
- W20548 cites W1992477495 @default.
- W20548 cites W1994315442 @default.
- W20548 cites W1996594271 @default.
- W20548 cites W1997311731 @default.
- W20548 cites W1998203607 @default.
- W20548 cites W1999943920 @default.
- W20548 cites W2003082888 @default.
- W20548 cites W2004854264 @default.
- W20548 cites W2005675562 @default.
- W20548 cites W2006335350 @default.
- W20548 cites W2008020112 @default.
- W20548 cites W2008242443 @default.
- W20548 cites W2008421466 @default.
- W20548 cites W2010791119 @default.
- W20548 cites W2013656579 @default.
- W20548 cites W2014827438 @default.
- W20548 cites W2014889227 @default.
- W20548 cites W2018240474 @default.
- W20548 cites W2019383583 @default.
- W20548 cites W2022395399 @default.
- W20548 cites W2027862889 @default.
- W20548 cites W2032822177 @default.
- W20548 cites W2034412957 @default.
- W20548 cites W2036272929 @default.
- W20548 cites W2038578669 @default.
- W20548 cites W2039601123 @default.
- W20548 cites W2039733070 @default.
- W20548 cites W2041550708 @default.
- W20548 cites W2042161313 @default.
- W20548 cites W2044587449 @default.
- W20548 cites W2044876445 @default.
- W20548 cites W2048404789 @default.
- W20548 cites W2050448117 @default.
- W20548 cites W2051403674 @default.
- W20548 cites W2051665833 @default.
- W20548 cites W2053813987 @default.
- W20548 cites W2055809956 @default.
- W20548 cites W2056503158 @default.
- W20548 cites W2057490727 @default.
- W20548 cites W2057909972 @default.
- W20548 cites W2057935845 @default.
- W20548 cites W2059739634 @default.
- W20548 cites W2060072724 @default.
- W20548 cites W2060072866 @default.
- W20548 cites W2064150650 @default.
- W20548 cites W2065073025 @default.
- W20548 cites W2065321720 @default.
- W20548 cites W2065417808 @default.
- W20548 cites W2065933164 @default.
- W20548 cites W2067179276 @default.
- W20548 cites W2067336382 @default.
- W20548 cites W2068353831 @default.
- W20548 cites W2070528905 @default.
- W20548 cites W2076444436 @default.
- W20548 cites W2078014987 @default.
- W20548 cites W2080268147 @default.
- W20548 cites W2080696342 @default.