Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054803480> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2054803480 endingPage "53" @default.
- W2054803480 startingPage "46" @default.
- W2054803480 abstract "C1311 (5-[[2-(diethylamino)ethyl]amino]-8-hydroxyimidazo [4,5,1-de]-acridin-6-one-dihydrochloride trihydrate) is the lead compound from the group of imidazoacridinones, a novel group of rationally designed anticancer agents. The pharmaceutical development of C1311 necessitated the availability of an assay for the quantification and purity determination of C1311 active pharmaceutical ingredient (API) and its pharmaceutical dosage form. A reversed-phase liquid chromatographic method (RP-LC) with ultraviolet (UV) detection was developed, consisting of separation on a C18 column with phosphate buffer (60 mM; pH 3 with 1 M citric acid)-acetonitrile-triethylamine (83:17:0.05, v/v/v) as the mobile phase and UV-detection at 280 nm. The method was found to be linear over a concentration range of 2.50-100 microg/mL, precise and accurate. Accelerated stress testing showed degradation products, which were well separated from the parent compound, confirming its stability-indicating capacity. Moreover, the use of LC-MS and on-line photo diode array detection enabled us to propose structures for four degradation products. Two of these products were also found as impurities in the API and more abundantly in an impure lot of API." @default.
- W2054803480 created "2016-06-24" @default.
- W2054803480 creator A5002441953 @default.
- W2054803480 creator A5006789264 @default.
- W2054803480 creator A5021228643 @default.
- W2054803480 creator A5030654482 @default.
- W2054803480 creator A5062227574 @default.
- W2054803480 creator A5085958205 @default.
- W2054803480 date "2005-09-01" @default.
- W2054803480 modified "2023-10-02" @default.
- W2054803480 title "Development and validation of an LC–UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form" @default.
- W2054803480 cites W1486176279 @default.
- W2054803480 cites W1641325306 @default.
- W2054803480 cites W1978342183 @default.
- W2054803480 cites W1980912347 @default.
- W2054803480 cites W1985334775 @default.
- W2054803480 cites W2000538691 @default.
- W2054803480 cites W2008848392 @default.
- W2054803480 cites W2009581961 @default.
- W2054803480 cites W2030501423 @default.
- W2054803480 cites W2050359740 @default.
- W2054803480 cites W2064760807 @default.
- W2054803480 cites W2076623463 @default.
- W2054803480 cites W2148194593 @default.
- W2054803480 cites W2411880571 @default.
- W2054803480 doi "https://doi.org/10.1016/j.jpba.2005.02.038" @default.
- W2054803480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15899571" @default.
- W2054803480 hasPublicationYear "2005" @default.
- W2054803480 type Work @default.
- W2054803480 sameAs 2054803480 @default.
- W2054803480 citedByCount "8" @default.
- W2054803480 countsByYear W20548034802014 @default.
- W2054803480 countsByYear W20548034802020 @default.
- W2054803480 crossrefType "journal-article" @default.
- W2054803480 hasAuthorship W2054803480A5002441953 @default.
- W2054803480 hasAuthorship W2054803480A5006789264 @default.
- W2054803480 hasAuthorship W2054803480A5021228643 @default.
- W2054803480 hasAuthorship W2054803480A5030654482 @default.
- W2054803480 hasAuthorship W2054803480A5062227574 @default.
- W2054803480 hasAuthorship W2054803480A5085958205 @default.
- W2054803480 hasConcept C106186310 @default.
- W2054803480 hasConcept C178790620 @default.
- W2054803480 hasConcept C179998833 @default.
- W2054803480 hasConcept C185592680 @default.
- W2054803480 hasConcept C2777463227 @default.
- W2054803480 hasConcept C2777682752 @default.
- W2054803480 hasConcept C2779032678 @default.
- W2054803480 hasConcept C2779679103 @default.
- W2054803480 hasConcept C2781283055 @default.
- W2054803480 hasConcept C2992520659 @default.
- W2054803480 hasConcept C41008148 @default.
- W2054803480 hasConcept C43617362 @default.
- W2054803480 hasConcept C45188465 @default.
- W2054803480 hasConcept C45904493 @default.
- W2054803480 hasConcept C71924100 @default.
- W2054803480 hasConcept C76155785 @default.
- W2054803480 hasConcept C77281830 @default.
- W2054803480 hasConcept C98274493 @default.
- W2054803480 hasConceptScore W2054803480C106186310 @default.
- W2054803480 hasConceptScore W2054803480C178790620 @default.
- W2054803480 hasConceptScore W2054803480C179998833 @default.
- W2054803480 hasConceptScore W2054803480C185592680 @default.
- W2054803480 hasConceptScore W2054803480C2777463227 @default.
- W2054803480 hasConceptScore W2054803480C2777682752 @default.
- W2054803480 hasConceptScore W2054803480C2779032678 @default.
- W2054803480 hasConceptScore W2054803480C2779679103 @default.
- W2054803480 hasConceptScore W2054803480C2781283055 @default.
- W2054803480 hasConceptScore W2054803480C2992520659 @default.
- W2054803480 hasConceptScore W2054803480C41008148 @default.
- W2054803480 hasConceptScore W2054803480C43617362 @default.
- W2054803480 hasConceptScore W2054803480C45188465 @default.
- W2054803480 hasConceptScore W2054803480C45904493 @default.
- W2054803480 hasConceptScore W2054803480C71924100 @default.
- W2054803480 hasConceptScore W2054803480C76155785 @default.
- W2054803480 hasConceptScore W2054803480C77281830 @default.
- W2054803480 hasConceptScore W2054803480C98274493 @default.
- W2054803480 hasIssue "1-2" @default.
- W2054803480 hasLocation W20548034801 @default.
- W2054803480 hasLocation W20548034802 @default.
- W2054803480 hasOpenAccess W2054803480 @default.
- W2054803480 hasPrimaryLocation W20548034801 @default.
- W2054803480 hasRelatedWork W1511678538 @default.
- W2054803480 hasRelatedWork W1995375582 @default.
- W2054803480 hasRelatedWork W1995604348 @default.
- W2054803480 hasRelatedWork W2024753328 @default.
- W2054803480 hasRelatedWork W2046604074 @default.
- W2054803480 hasRelatedWork W2054803480 @default.
- W2054803480 hasRelatedWork W2080734868 @default.
- W2054803480 hasRelatedWork W2087046738 @default.
- W2054803480 hasRelatedWork W2089660391 @default.
- W2054803480 hasRelatedWork W2327959207 @default.
- W2054803480 hasVolume "39" @default.
- W2054803480 isParatext "false" @default.
- W2054803480 isRetracted "false" @default.
- W2054803480 magId "2054803480" @default.
- W2054803480 workType "article" @default.