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• W2054803742 endingPage "4803" @default.
• W2054803742 startingPage "4797" @default.
• W2054803742 abstract "At slightly acidic or even neutral pH, oligodeoxynucleotides that include a stretch of cytidines have been shown to form a tetrameric structure in which two parallel-stranded duplexes have their hemiprotonated C.C+ base pairs face to face and fully intercalated, in a so-called i-motif. Cytosine-rich pyrimidine oligodeoxynucleotides can form an intramolecular i-motif. We have studied the ability of several DNA analogs to fold into this structure. Evidence for folding was provided by thermal denaturation. We have shown that phosphorothioate and phosphodiester oligodeoxynucleotides, but not methylphosphonate or PNA oligomers, may form the i-motif. Four different PS oligodeoxynucleotides were compared with their PO counterparts. In all cases, the melting temperature (Tm) of the phosphorothioate oligomer was equal or slightly inferior (by 2–3°C) to the Tm of the natural oligodeoxynucleotide. For long oligodeoxynucleotides, a small change of pH leads to a completely different melting profile: the curves are reversible at pH 6.4 or lower, and a hysteresis is obtained at pH 6.8 or higher; cooling and heating curves were not superimposed, allowing us to determine the rate constants of association (kon) and dissociation (koff) as a function of the temperature: these rate constants give linear Arrhenius plots, in agreement with the prediction of the two-state model of association-dissociation. The activation energy Eon is strongly negative and, at neutral pH, the phosphorothioate associates and dissociates nine times faster than the phosphodiester oligodeoxynucleotide of identical sequence." @default.
• W2054803742 created "2016-06-24" @default.
• W2054803742 creator A5050656020 @default.
• W2054803742 creator A5050850407 @default.
• W2054803742 date "1998-11-01" @default.
• W2054803742 modified "2023-10-10" @default.
• W2054803742 title "Kinetics and thermodynamics of i-DNA formation: phosphodiester versus modified oligodeoxynucleotides" @default.
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• W2054803742 doi "https://doi.org/10.1093/nar/26.21.4797" @default.
• W2054803742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/147917" @default.
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• W2054803742 hasPublicationYear "1998" @default.
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