Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054825323> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2054825323 endingPage "3114" @default.
- W2054825323 startingPage "3109" @default.
- W2054825323 abstract "Abstract The lysosomal function of mucopolysaccharide degradation in normal cultured, living human fibroblasts can specifically be inhibited without affecting over-all cell viability or growth. In an earlier report we have shown that an increase in medium pH will progressively inhibit this function. The present paper demonstrates that chloroquine in concentrations around 1–2 × 10−5 M strongly interferes with mucopolysaccharide degradation in the living cell. Electron microscopy shows that a morphological picture resembling a lysosomal storage disease develops in these cells after less than 2 days exposure to the drug. We propose that the antimalarial effect of chloroquine (and preliminary results would include quinacrine and quinine) and at least some of the major side effects of the drug are due to the same basic mechanism: an inhibition of normal lysosomal activities in the parasite as well as in the human cell." @default.
- W2054825323 created "2016-06-24" @default.
- W2054825323 creator A5064252850 @default.
- W2054825323 creator A5079055046 @default.
- W2054825323 date "1973-12-01" @default.
- W2054825323 modified "2023-10-01" @default.
- W2054825323 title "Inactivation of lysosomal function in normal cultured human fibroblasts by chloroquine" @default.
- W2054825323 cites W1670697904 @default.
- W2054825323 cites W1973443840 @default.
- W2054825323 cites W2006511704 @default.
- W2054825323 cites W2012905268 @default.
- W2054825323 cites W2014975553 @default.
- W2054825323 cites W2025311742 @default.
- W2054825323 cites W2025562800 @default.
- W2054825323 cites W2028491565 @default.
- W2054825323 cites W2053336639 @default.
- W2054825323 cites W2054917604 @default.
- W2054825323 cites W2059045112 @default.
- W2054825323 cites W2063316977 @default.
- W2054825323 cites W2064616746 @default.
- W2054825323 cites W2077824916 @default.
- W2054825323 cites W2080494706 @default.
- W2054825323 cites W2099544839 @default.
- W2054825323 doi "https://doi.org/10.1016/0006-2952(73)90197-4" @default.
- W2054825323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4271529" @default.
- W2054825323 hasPublicationYear "1973" @default.
- W2054825323 type Work @default.
- W2054825323 sameAs 2054825323 @default.
- W2054825323 citedByCount "149" @default.
- W2054825323 countsByYear W20548253232012 @default.
- W2054825323 countsByYear W20548253232013 @default.
- W2054825323 countsByYear W20548253232016 @default.
- W2054825323 countsByYear W20548253232018 @default.
- W2054825323 countsByYear W20548253232020 @default.
- W2054825323 countsByYear W20548253232022 @default.
- W2054825323 countsByYear W20548253232023 @default.
- W2054825323 crossrefType "journal-article" @default.
- W2054825323 hasAuthorship W2054825323A5064252850 @default.
- W2054825323 hasAuthorship W2054825323A5079055046 @default.
- W2054825323 hasConcept C14036430 @default.
- W2054825323 hasConcept C185592680 @default.
- W2054825323 hasConcept C202751555 @default.
- W2054825323 hasConcept C203014093 @default.
- W2054825323 hasConcept C2777425658 @default.
- W2054825323 hasConcept C2778048844 @default.
- W2054825323 hasConcept C2780381497 @default.
- W2054825323 hasConcept C55493867 @default.
- W2054825323 hasConcept C86803240 @default.
- W2054825323 hasConcept C95444343 @default.
- W2054825323 hasConcept C98274493 @default.
- W2054825323 hasConceptScore W2054825323C14036430 @default.
- W2054825323 hasConceptScore W2054825323C185592680 @default.
- W2054825323 hasConceptScore W2054825323C202751555 @default.
- W2054825323 hasConceptScore W2054825323C203014093 @default.
- W2054825323 hasConceptScore W2054825323C2777425658 @default.
- W2054825323 hasConceptScore W2054825323C2778048844 @default.
- W2054825323 hasConceptScore W2054825323C2780381497 @default.
- W2054825323 hasConceptScore W2054825323C55493867 @default.
- W2054825323 hasConceptScore W2054825323C86803240 @default.
- W2054825323 hasConceptScore W2054825323C95444343 @default.
- W2054825323 hasConceptScore W2054825323C98274493 @default.
- W2054825323 hasIssue "23" @default.
- W2054825323 hasLocation W20548253231 @default.
- W2054825323 hasLocation W20548253232 @default.
- W2054825323 hasOpenAccess W2054825323 @default.
- W2054825323 hasPrimaryLocation W20548253231 @default.
- W2054825323 hasRelatedWork W1057109913 @default.
- W2054825323 hasRelatedWork W2004724551 @default.
- W2054825323 hasRelatedWork W2039510430 @default.
- W2054825323 hasRelatedWork W2102562378 @default.
- W2054825323 hasRelatedWork W2171449327 @default.
- W2054825323 hasRelatedWork W2299952731 @default.
- W2054825323 hasRelatedWork W2394694094 @default.
- W2054825323 hasRelatedWork W2433681220 @default.
- W2054825323 hasRelatedWork W3136974682 @default.
- W2054825323 hasRelatedWork W51497714 @default.
- W2054825323 hasVolume "22" @default.
- W2054825323 isParatext "false" @default.
- W2054825323 isRetracted "false" @default.
- W2054825323 magId "2054825323" @default.
- W2054825323 workType "article" @default.