FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054828475> ?p ?o ?g. }

• W2054828475 endingPage "889" @default.
• W2054828475 startingPage "883" @default.
• W2054828475 abstract "Objective O6-methylguanine-DNA methyltransferase (MGMT) ameliorates mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) with promoter hypermethylation and with betel quid chewing and cigarette smoking. Study design MGMT protein expression in 63 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Methylation status of the MGMT was analyzed by methylation-specific PCR. Correlation with clinicopathologic parameters was then tested by statistical analysis. Results MGMT immunohistochemistry revealed nuclear staining in normal epithelium, whereas 47 (75%) of 63 OSCC tumors were devoid of MGMT expression and this was related to tumor cell differentiation. Furthermore, the association between loss of MGMT expression and promoter hypermethylation was significant. Lacking protein expression for MGMT in OSCC was also associated with the use of betel quid. Conclusions The results suggest that the absence of MGMT expression, which would seem to be associated with promoter hypermethylation, is related to betel quid chewing and, thus, in turn, might be a significant event in oral carcinogenesis. O6-methylguanine-DNA methyltransferase (MGMT) ameliorates mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) with promoter hypermethylation and with betel quid chewing and cigarette smoking. MGMT protein expression in 63 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Methylation status of the MGMT was analyzed by methylation-specific PCR. Correlation with clinicopathologic parameters was then tested by statistical analysis. MGMT immunohistochemistry revealed nuclear staining in normal epithelium, whereas 47 (75%) of 63 OSCC tumors were devoid of MGMT expression and this was related to tumor cell differentiation. Furthermore, the association between loss of MGMT expression and promoter hypermethylation was significant. Lacking protein expression for MGMT in OSCC was also associated with the use of betel quid. The results suggest that the absence of MGMT expression, which would seem to be associated with promoter hypermethylation, is related to betel quid chewing and, thus, in turn, might be a significant event in oral carcinogenesis." @default.
• W2054828475 created "2016-06-24" @default.
• W2054828475 creator A5027754836 @default.
• W2054828475 creator A5032847070 @default.
• W2054828475 creator A5046876193 @default.
• W2054828475 creator A5083959152 @default.
• W2054828475 creator A5084721080 @default.
• W2054828475 creator A5091364683 @default.
• W2054828475 date "2010-06-01" @default.
• W2054828475 modified "2023-10-03" @default.
• W2054828475 title "Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma" @default.
• W2054828475 cites W1966311470 @default.
• W2054828475 cites W1968398558 @default.
• W2054828475 cites W1971344938 @default.
• W2054828475 cites W1974625504 @default.
• W2054828475 cites W1984516919 @default.
• W2054828475 cites W1994465394 @default.
• W2054828475 cites W1995387564 @default.
• W2054828475 cites W1999025579 @default.
• W2054828475 cites W2002213101 @default.
• W2054828475 cites W2004836271 @default.
• W2054828475 cites W2008466187 @default.
• W2054828475 cites W2008900878 @default.
• W2054828475 cites W2009885143 @default.
• W2054828475 cites W2012888872 @default.
• W2054828475 cites W2015930850 @default.
• W2054828475 cites W2025515800 @default.
• W2054828475 cites W2036085833 @default.
• W2054828475 cites W2038681450 @default.
• W2054828475 cites W2040258763 @default.
• W2054828475 cites W2053689350 @default.
• W2054828475 cites W2060099775 @default.
• W2054828475 cites W2061295141 @default.
• W2054828475 cites W2068622780 @default.
• W2054828475 cites W2072108674 @default.
• W2054828475 cites W2075895580 @default.
• W2054828475 cites W2082474628 @default.
• W2054828475 cites W2090416100 @default.
• W2054828475 cites W2095085903 @default.
• W2054828475 cites W2098140018 @default.
• W2054828475 cites W2105271269 @default.
• W2054828475 cites W2107949454 @default.
• W2054828475 cites W2119284573 @default.
• W2054828475 cites W2121893446 @default.
• W2054828475 cites W2136373954 @default.
• W2054828475 cites W2143665087 @default.
• W2054828475 cites W2147504123 @default.
• W2054828475 cites W2149677477 @default.
• W2054828475 cites W2152312047 @default.
• W2054828475 cites W2152322420 @default.
• W2054828475 cites W2161860271 @default.
• W2054828475 cites W2165509283 @default.
• W2054828475 cites W2166246430 @default.
• W2054828475 cites W2184926211 @default.
• W2054828475 cites W2328547481 @default.
• W2054828475 cites W4211004626 @default.
• W2054828475 cites W610657222 @default.
• W2054828475 doi "https://doi.org/10.1016/j.tripleo.2009.12.019" @default.
• W2054828475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20451846" @default.
• W2054828475 hasPublicationYear "2010" @default.
• W2054828475 type Work @default.
• W2054828475 sameAs 2054828475 @default.
• W2054828475 citedByCount "17" @default.
• W2054828475 countsByYear W20548284752012 @default.
• W2054828475 countsByYear W20548284752014 @default.
• W2054828475 countsByYear W20548284752015 @default.
• W2054828475 countsByYear W20548284752017 @default.
• W2054828475 countsByYear W20548284752019 @default.
• W2054828475 countsByYear W20548284752021 @default.
• W2054828475 crossrefType "journal-article" @default.
• W2054828475 hasAuthorship W2054828475A5027754836 @default.
• W2054828475 hasAuthorship W2054828475A5032847070 @default.
• W2054828475 hasAuthorship W2054828475A5046876193 @default.
• W2054828475 hasAuthorship W2054828475A5083959152 @default.
• W2054828475 hasAuthorship W2054828475A5084721080 @default.
• W2054828475 hasAuthorship W2054828475A5091364683 @default.
• W2054828475 hasConcept C104317684 @default.
• W2054828475 hasConcept C121608353 @default.
• W2054828475 hasConcept C127413603 @default.
• W2054828475 hasConcept C134935766 @default.
• W2054828475 hasConcept C142724271 @default.
• W2054828475 hasConcept C150194340 @default.
• W2054828475 hasConcept C190727270 @default.
• W2054828475 hasConcept C204232928 @default.
• W2054828475 hasConcept C206391251 @default.
• W2054828475 hasConcept C2777417228 @default.
• W2054828475 hasConcept C2779527866 @default.
• W2054828475 hasConcept C2779979206 @default.
• W2054828475 hasConcept C33288867 @default.
• W2054828475 hasConcept C502942594 @default.
• W2054828475 hasConcept C54355233 @default.
• W2054828475 hasConcept C552990157 @default.
• W2054828475 hasConcept C555283112 @default.
• W2054828475 hasConcept C66938386 @default.
• W2054828475 hasConcept C71924100 @default.
• W2054828475 hasConcept C86803240 @default.
• W2054828475 hasConcept C91965660 @default.
• W2054828475 hasConceptScore W2054828475C104317684 @default.

• next