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• W2054841244 abstract "Febrifugine, a quinazoline alkaloid isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. Although the use of ferifugine as an antimalarial drug has been precluded because of its severe side effects, its potent antimalarial activity has stimulated medicinal chemists to pursue its derivatives instead, which may provide valuable leads for novel antimalarial drugs. In the present study, we synthesized new derivatives of febrifugine and evaluated their in vitro and in vivo antimalarial activities to develop antimalarials that are more effective and safer. As a result, we proposed tetrahydroquinazoline-type derivative as a safe and effective antimalarial candidate." @default.
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• W2054841244 date "2014-04-01" @default.
• W2054841244 modified "2023-09-23" @default.
• W2054841244 title "Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial" @default.
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• W2054841244 doi "https://doi.org/10.1016/j.ejmech.2014.01.036" @default.
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