Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054851504> ?p ?o ?g. }
- W2054851504 endingPage "69" @default.
- W2054851504 startingPage "54" @default.
- W2054851504 abstract "Central nervous system (CNS) risks which include during space missions and lifetime risks due to space radiation exposure are of concern for long-term exploration missions to Mars or other destinations. Possible CNS risks during a mission are altered cognitive function, including detriments in short-term memory, reduced motor function, and behavioral changes, which may affect performance and human health. The late CNS risks are possible neurological disorders such as premature aging, and Alzheimer's disease (AD) or other dementia. Radiation safety requirements are intended to prevent all clinically significant acute risks. However the definition of clinically significant CNS risks and their dependences on dose, dose-rate and radiation quality is poorly understood at this time. For late CNS effects such as increased risk of AD, the occurrence of the disease is fatal with mean time from diagnosis of early stage AD to death about 8 years. Therefore if AD risk or other late CNS risks from space radiation occur at mission relevant doses, they would naturally be included in the overall acceptable risk of exposure induced death (REID) probability for space missions. Important progress has been made in understanding CNS risks due to space radiation exposure, however in general the doses used in experimental studies have been much higher than the annual galactic cosmic ray (GCR) dose (∼0.1 Gy/y at solar maximum and ∼0.2 Gy/y at solar minimum with less than 50% from HZE particles). In this report we summarize recent space radiobiology studies of CNS effects from particle accelerators simulating space radiation using experimental models, and make a critical assessment of their relevance relative to doses and dose-rates to be incurred on a Mars mission. Prospects for understanding dose, dose-rate and radiation quality dependencies of CNS effects and extrapolation to human risk assessments are described." @default.
- W2054851504 created "2016-06-24" @default.
- W2054851504 creator A5024136945 @default.
- W2054851504 creator A5048815711 @default.
- W2054851504 creator A5059239993 @default.
- W2054851504 creator A5090512101 @default.
- W2054851504 date "2014-07-01" @default.
- W2054851504 modified "2023-10-10" @default.
- W2054851504 title "Space radiation risks to the central nervous system" @default.
- W2054851504 cites W1533697808 @default.
- W2054851504 cites W164290047 @default.
- W2054851504 cites W1853248243 @default.
- W2054851504 cites W1905507378 @default.
- W2054851504 cites W1965942744 @default.
- W2054851504 cites W1968435538 @default.
- W2054851504 cites W1969133124 @default.
- W2054851504 cites W1970475719 @default.
- W2054851504 cites W1970595065 @default.
- W2054851504 cites W1972840914 @default.
- W2054851504 cites W1973857253 @default.
- W2054851504 cites W1974993806 @default.
- W2054851504 cites W1976487775 @default.
- W2054851504 cites W1978384434 @default.
- W2054851504 cites W1981853492 @default.
- W2054851504 cites W1984014309 @default.
- W2054851504 cites W1984214648 @default.
- W2054851504 cites W1985283713 @default.
- W2054851504 cites W1986311655 @default.
- W2054851504 cites W1987103506 @default.
- W2054851504 cites W1993070424 @default.
- W2054851504 cites W1993199173 @default.
- W2054851504 cites W1997330333 @default.
- W2054851504 cites W1998073936 @default.
- W2054851504 cites W1998873528 @default.
- W2054851504 cites W2000857455 @default.
- W2054851504 cites W2003208985 @default.
- W2054851504 cites W2004024464 @default.
- W2054851504 cites W2006703820 @default.
- W2054851504 cites W2008727690 @default.
- W2054851504 cites W2012594443 @default.
- W2054851504 cites W2012957267 @default.
- W2054851504 cites W2013036835 @default.
- W2054851504 cites W2013459365 @default.
- W2054851504 cites W2013669877 @default.
- W2054851504 cites W2015506862 @default.
- W2054851504 cites W2016679507 @default.
- W2054851504 cites W2016864238 @default.
- W2054851504 cites W2019737348 @default.
- W2054851504 cites W2020278984 @default.
- W2054851504 cites W2021826353 @default.
- W2054851504 cites W2027278399 @default.
- W2054851504 cites W2027696834 @default.
- W2054851504 cites W2037803738 @default.
- W2054851504 cites W2040949523 @default.
- W2054851504 cites W2041952945 @default.
- W2054851504 cites W2042967751 @default.
- W2054851504 cites W2043787257 @default.
- W2054851504 cites W2045533008 @default.
- W2054851504 cites W2047585091 @default.
- W2054851504 cites W2047702340 @default.
- W2054851504 cites W2047854761 @default.
- W2054851504 cites W2050523292 @default.
- W2054851504 cites W2051411576 @default.
- W2054851504 cites W2052024305 @default.
- W2054851504 cites W2053825022 @default.
- W2054851504 cites W2054238889 @default.
- W2054851504 cites W2054499450 @default.
- W2054851504 cites W2054538771 @default.
- W2054851504 cites W2057271700 @default.
- W2054851504 cites W2058058526 @default.
- W2054851504 cites W2061322827 @default.
- W2054851504 cites W2061995059 @default.
- W2054851504 cites W2065448919 @default.
- W2054851504 cites W2066622479 @default.
- W2054851504 cites W2068009572 @default.
- W2054851504 cites W2068243669 @default.
- W2054851504 cites W2068368375 @default.
- W2054851504 cites W2068930946 @default.
- W2054851504 cites W2069308124 @default.
- W2054851504 cites W2069930429 @default.
- W2054851504 cites W2070883106 @default.
- W2054851504 cites W2073875806 @default.
- W2054851504 cites W2074198118 @default.
- W2054851504 cites W2078924802 @default.
- W2054851504 cites W2079917933 @default.
- W2054851504 cites W2081843173 @default.
- W2054851504 cites W2082438573 @default.
- W2054851504 cites W2085408461 @default.
- W2054851504 cites W2086118086 @default.
- W2054851504 cites W2088384195 @default.
- W2054851504 cites W2091936448 @default.
- W2054851504 cites W2092810225 @default.
- W2054851504 cites W2096435270 @default.
- W2054851504 cites W2097578302 @default.
- W2054851504 cites W2098137179 @default.
- W2054851504 cites W2098689751 @default.
- W2054851504 cites W2099016813 @default.
- W2054851504 cites W2099218553 @default.