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- W2054852932 abstract "Tuberculosis and leprosy are among the major communicable diseases in the developing countries. It is estimated that every year about 10 million people develop tuberculosis and there are about 12 million people suffering from leprosyl. In the chemotherapy of both these diseases one very successful drug is rifampicin2-5. Rifampicin is a semisynthetic derivative of the microbial metabolites belonging to the ansamycin group of antibiotics, the rifamycins 6. Among the new drugs being explored for a better treatment of mycobacterial infections, rifamycin derivatives have great potential’. Microbial production of these rifamycins yields a mixture of many closely related members, among which the rifamycins B, 0, S and SV are of commercial importance. Although some methods of identification”s8p10 and quantitation’l exist, none really offers complete analysis. Using high-performance liquid chromatography (HPLC) a method which effectively separates and quantitates these rifamycins (Fig. 1) has been achieved." @default.
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- W2054852932 date "1989-01-01" @default.
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- W2054852932 title "Identification and quantitation of rifamycins by reversed-phase high-performance liquid chromatography" @default.
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- W2054852932 doi "https://doi.org/10.1016/s0021-9673(01)89658-8" @default.
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