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- W2054865420 abstract "No AccessJournal of UrologyAdult Urology1 Feb 2011Older Age Is Associated With Similar Improvements in Semen Parameters and Testosterone After Subinguinal Microsurgical Varicocelectomy Wayland Hsiao, James S. Rosoff, Joseph R. Pale, Eleni A. Greenwood, and Marc Goldstein Wayland HsiaoWayland Hsiao Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York Institute for Reproductive Medicine, Weill Cornell Medical College, New York, New York The Population Council Center for Biomedical Research, New York, New York More articles by this author , James S. RosoffJames S. Rosoff Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , Joseph R. PaleJoseph R. Pale Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , Eleni A. GreenwoodEleni A. Greenwood Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , and Marc GoldsteinMarc Goldstein Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York Institute for Reproductive Medicine, Weill Cornell Medical College, New York, New York The Population Council Center for Biomedical Research, New York, New York More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.09.114AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: It is generally accepted that men with clinically palpable varicocele are at high risk for a progressive decrease in fertility and testosterone levels with time. Varicocelectomy is thought to improve testicular function or at least halt the accelerated decrease in testicular function associated with varicocele. Substantial controversy exists as to whether varicocelectomy is effective in older men, possibly due to irreversible testicular damage or limited potential for recovery from varicocele induced damage. Materials and Methods: We retrospectively reviewed the records of men who underwent microsurgical subinguinal varicocelectomy, as done by a single surgeon. Demographics, patient questionnaires, operative notes, charts, testosterone and semen analysis were reviewed. Patients were divided into 3 groups based on age at surgery, including less than 30, 30 to 39 and 40 years or greater. Results: A total of 272 men met study inclusion criteria. In all 3 age groups we noted similar testosterone and baseline semen analysis parameters. There were significant increases in sperm concentration and total sperm count in all age groups. When analysis was restricted to men with baseline testosterone 400 ng/dl or less, there was a mean 110, 133 and 136 ng/dl increase in 21 men who were 40 years old or older, in 30 who were 30 to 39 years old and in 21 who were younger than 30 years, respectively. Conclusions: Microsurgical varicocelectomy resulted in significant increases in sperm concentration, total sperm count and testosterone in all age groups studied, including men in the fifth and sixth decades of life. Microsurgical varicocelectomy should be offered to older men for infertility and/or hypogonadism. References 1 : Loss of fertility in men with varicocele. Fertil Steril1993; 59: 613. Google Scholar 2 : Varicocele, age, and fertility. Lancet1957; 273: 222. Google Scholar 3 : Progressive testicular atrophy in the varicocele patient. J Urol1977; 117: 175. Link, Google Scholar 4 : Varicocele: temporal considerations. J Urol1985; 134: 411. 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Link, Google Scholar 13 : Effect of age and grade on surgery for patients with varicocele. Urology2005; 65: 768. Google Scholar 14 : Varicocelectomy for infertile couples with advanced paternal age. Urology2008; 72: 109. Google Scholar 15 : Microsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique. J Urol1992; 148: 1808. Link, Google Scholar 16 : Optimal power transformations for analysis of sperm concentration and other semen variables. J Androl2002; 23: 629. Google Scholar © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byNiederberger C (2019) Re: Fate of Recurrent or Persistent Varicocele in the Era of Assisted Reproduction Technology: Microsurgical Subinguinal Redo Varicocelectomy versus ObservationJournal of Urology, VOL. 201, NO. 4, (651-652), Online publication date: 1-Apr-2019.Niederberger C (2018) Re: Effects of Varicocele on Serum Testosterone and Changes of Testosterone after Varicocelectomy: A Prospective Controlled StudyJournal of Urology, VOL. 193, NO. 6, (2054-2054), Online publication date: 1-Jun-2015. Volume 185Issue 2February 2011Page: 620-625 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordsagingtestisinfertility, malevaricocelehypogonadismMetricsAuthor Information Wayland Hsiao Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York Institute for Reproductive Medicine, Weill Cornell Medical College, New York, New York The Population Council Center for Biomedical Research, New York, New York More articles by this author James S. Rosoff Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Joseph R. Pale Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Eleni A. Greenwood Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Marc Goldstein Center for Male Reproductive Medicine, Department of Urology, Weill Cornell Medical College, New York, New York Institute for Reproductive Medicine, Weill Cornell Medical College, New York, New York The Population Council Center for Biomedical Research, New York, New York More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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- W2054865420 title "Older Age Is Associated With Similar Improvements in Semen Parameters and Testosterone After Subinguinal Microsurgical Varicocelectomy" @default.
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