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• W2054865452 abstract "Objectives: Pitavastatin, a statin recently approved in the United States, has a potential benefit of reduced risk of cytochrome P450 (CYP)-mediated drug-drug interaction due to minimal metabolism by the CYP system. The primary objective was to investigate pharmacokinetic (PK) effects of lopinavir/ritonavir 400 mg/100 mg twice daily on pitavastatin 4 mg when coadministered. Design: This was an open-label one-arm study. Method: Pitavastatin 4 mg was administered once daily (days 1–5 and days 20–24). Lopinavir/ritonavir 400 mg/100 mg was administered twice daily (days 9–24). Plasma samples for PK assessments were collected on days 5, 19, and 24. Plasma concentrations of analytes were determined by liquid chromatography with tandem mass spectrometric detection methods. Results: PK data were available for 23 of 24 subjects enrolled. For pitavastatin, area under the concentration time curve (AUC0-τ) and maximum concentration (Cmax) were 136.8 ± 52.9 ng·h−1·mL−1 and 58.6 ± 30.4 ng/mL, respectively, when given alone, versus 113.9 ± 53.8 ng·h−1·mL−1 and 58.2 ± 32.7 ng/mL when combined with lopinavir/ritonavir. The geometric mean ratio for AUC0-τ for pitavastatin with lopinavir/ritonavir versus pitavastatin alone was 80.0 (90% confidence interval: 73.4 to 87.3) and Cmax was 96.1 (90% confidence interval: 83.6 to 110.4). Median Tmax of pitavastatin was approximately 0.5 hours for both treatments. The PK effect of pitavastatin on lopinavir/ritonavir was minimal. No significant safety issues were reported. Conclusions: The effect on exposures when pitavastatin and lopinavir/ritonavir are coadministered was minimal. Concomitant use of pitavastatin and lopinavir/ritonavir was safe and well tolerated in healthy adult volunteers." @default.
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• W2054865452 date "2012-06-01" @default.
• W2054865452 modified "2023-10-18" @default.
• W2054865452 title "Effects of Steady-State Lopinavir/Ritonavir on the Pharmacokinetics of Pitavastatin in Healthy Adult Volunteers" @default.
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• W2054865452 doi "https://doi.org/10.1097/qai.0b013e318251addb" @default.
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