Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054865983> ?p ?o ?g. }
- W2054865983 endingPage "28" @default.
- W2054865983 startingPage "11" @default.
- W2054865983 abstract "Star-PAP is a recently identified nuclear speckle localized non-canonical poly(A) polymerase that has a functional interaction with PIPKIα, and whose activity is modulated by the PIPKIα product, PI4,5P2. Similar to other poly(A) polymerases, such as the canonical PAPα and the non-canonical GLD2 PAP, Star-PAP resides in a large complex of proteins involved in the 3’ end formation of mRNAs (Fig. 4). The Star-PAP complex shares components with the canonical PAPα complex though contains unique associated proteins such as PIPKIα and CKIα. The Star-PAP complex assembles into a highly stable 3’ end processing machine upon oxidative stress induction. This assembled complex shows enhanced enzyme activity and hypersensitivity to exogenous PI4,5P2, implying that an activated Star-PAP is distinctly modified and/or contains unique factors as compared to Star-PAP purified from resting cells.Open in a separate windowFig. 4Model of the Star-PAP complex induced to assemble on its target gene ho-1 for the 3’ end processing of HO-1 mRNA. A stimuli such as oxidative stress induction can drive the inclusion of a phosphoinositide signaling components PIPKIα and CKIα into a stable Star-PAP complex that targets the stress response gene heme oxygenase-1, ho-1." @default.
- W2054865983 created "2016-06-24" @default.
- W2054865983 creator A5033937372 @default.
- W2054865983 creator A5046540673 @default.
- W2054865983 date "2009-01-01" @default.
- W2054865983 modified "2023-10-16" @default.
- W2054865983 title "A novel gene expression pathway regulated by nuclear phosphoinositides" @default.
- W2054865983 cites W1484266107 @default.
- W2054865983 cites W1485174126 @default.
- W2054865983 cites W1486424890 @default.
- W2054865983 cites W1486704577 @default.
- W2054865983 cites W1532399000 @default.
- W2054865983 cites W1542016002 @default.
- W2054865983 cites W1567781970 @default.
- W2054865983 cites W1570946718 @default.
- W2054865983 cites W1585436889 @default.
- W2054865983 cites W1589281117 @default.
- W2054865983 cites W1595469067 @default.
- W2054865983 cites W1599007124 @default.
- W2054865983 cites W1606695388 @default.
- W2054865983 cites W1626321408 @default.
- W2054865983 cites W170591362 @default.
- W2054865983 cites W1793858878 @default.
- W2054865983 cites W1812352443 @default.
- W2054865983 cites W1911659752 @default.
- W2054865983 cites W1968686367 @default.
- W2054865983 cites W1972297273 @default.
- W2054865983 cites W1973162628 @default.
- W2054865983 cites W1973210624 @default.
- W2054865983 cites W1974707221 @default.
- W2054865983 cites W1977412572 @default.
- W2054865983 cites W1979566467 @default.
- W2054865983 cites W1980159882 @default.
- W2054865983 cites W1983467802 @default.
- W2054865983 cites W1983992348 @default.
- W2054865983 cites W1985764146 @default.
- W2054865983 cites W1988309554 @default.
- W2054865983 cites W1988572987 @default.
- W2054865983 cites W1993334394 @default.
- W2054865983 cites W1993659955 @default.
- W2054865983 cites W1994152217 @default.
- W2054865983 cites W1995179192 @default.
- W2054865983 cites W1996831533 @default.
- W2054865983 cites W1998026805 @default.
- W2054865983 cites W1998451617 @default.
- W2054865983 cites W1999405592 @default.
- W2054865983 cites W2000702625 @default.
- W2054865983 cites W2000932018 @default.
- W2054865983 cites W2001321924 @default.
- W2054865983 cites W2001766446 @default.
- W2054865983 cites W2004241043 @default.
- W2054865983 cites W2004824571 @default.
- W2054865983 cites W2004864204 @default.
- W2054865983 cites W2005351471 @default.
- W2054865983 cites W2005664674 @default.
- W2054865983 cites W2006739525 @default.
- W2054865983 cites W2009342933 @default.
- W2054865983 cites W2009671832 @default.
- W2054865983 cites W2009976155 @default.
- W2054865983 cites W2011314862 @default.
- W2054865983 cites W2013146348 @default.
- W2054865983 cites W2014739284 @default.
- W2054865983 cites W2015999110 @default.
- W2054865983 cites W2016077331 @default.
- W2054865983 cites W2017846843 @default.
- W2054865983 cites W2021682292 @default.
- W2054865983 cites W2022121903 @default.
- W2054865983 cites W2022555897 @default.
- W2054865983 cites W2024981123 @default.
- W2054865983 cites W2027231986 @default.
- W2054865983 cites W2027414376 @default.
- W2054865983 cites W2027724167 @default.
- W2054865983 cites W2028012837 @default.
- W2054865983 cites W2028867134 @default.
- W2054865983 cites W2030011185 @default.
- W2054865983 cites W2030107341 @default.
- W2054865983 cites W2030262696 @default.
- W2054865983 cites W2030296716 @default.
- W2054865983 cites W2031546477 @default.
- W2054865983 cites W2031613155 @default.
- W2054865983 cites W2031969205 @default.
- W2054865983 cites W2033540751 @default.
- W2054865983 cites W2039086575 @default.
- W2054865983 cites W2039169423 @default.
- W2054865983 cites W2041909095 @default.
- W2054865983 cites W2047245916 @default.
- W2054865983 cites W2047733032 @default.
- W2054865983 cites W2048622566 @default.
- W2054865983 cites W2049221143 @default.
- W2054865983 cites W2050759207 @default.
- W2054865983 cites W2051241871 @default.
- W2054865983 cites W2051985718 @default.
- W2054865983 cites W2054755210 @default.
- W2054865983 cites W2054799935 @default.
- W2054865983 cites W2056070148 @default.
- W2054865983 cites W2056260693 @default.
- W2054865983 cites W2059162424 @default.
- W2054865983 cites W2059278893 @default.