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- W2054866367 abstract "The metabolic conjugation of estriol- 6,7-H3 was investigated in female sheep. The studies were performed in animals with bile fistulas, as well as in the intact state. Following the intravenous administration of estriol, the 3- sulfate and the 3-glucosiduronate were identified both in the urine and in the bile (the latter predominated in the bile). Concomitant studies with in vitro incubations of homogenates of liver, small intestine, and kidney showed that the liver readily conjugated estriol as the sulfate and glucosiduronate, the intestine readily formed the 3- glucosiduronate, and the kidney was a rather poor conjugating organ. From the in vivo and in vitro experiments the metabolic fate of estriol in sheep appears to involve its conjugation by the liver, both as the 3-sulfate and 3-glucosiduronate, with the latter primarily excreted into the bile. The estriol-3-glucosiduronate is readily reabsorbed from the gastrointestinal tract and excreted in the urine, thus establishing an enterohepatic circulat..." @default.
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- W2054866367 date "1972-02-01" @default.
- W2054866367 modified "2023-10-18" @default.
- W2054866367 title "Estriol Metabolism in Sheep: Excretion of Biliary and Urinary Conjugates*" @default.
- W2054866367 doi "https://doi.org/10.1210/endo-90-2-516" @default.
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