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- W2054870086 abstract "The influence of trimethoprim on total RNA synthesis of Escherichia coli in minimal medium was investigated, as well as the reversing abilities of its antagonists thymidine, adenosine, guanosine, methionine and glycine. A purine source and the amino acids glycine and methionine are sufficient for reversing the inhibition of RNA synthesis completely. The experiments demonstrate that the inhibition of RNA synthesis upon addition of 5 μg/ml trimethoprim in minimal medium is caused by a lack of purines as well as by control mechanisms via the deprived amino acids, as is known from stringent strains. The addition of the single substances to cultures inhibited by trimethoprim leads to a short-time stimulation of RNA synthesis. The nature of this stimulation is not completely understood, especially the stimulation by thymidine, which is not necessary for the reversal of inhibited RNA synthesis. Whereas the lack of methionine results in a very strong inhibition of RNA synthesis, it seems that the synthesis of purines is most sensitive to a shortage of tetrahydrofolate, and which is responsible for the rapid stop of RNA synthesis." @default.
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- W2054870086 date "1972-11-01" @default.
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- W2054870086 title "Effects of trimethoprim and its antagonists on RNA synthesis in Escherichia coli" @default.
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- W2054870086 doi "https://doi.org/10.1016/0005-2787(72)90333-4" @default.
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