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- W2054874911 abstract "The effects of a single oral dose of 25 mg carvedilol on the plasma and urinary kinetics of digoxin after an oral and intravenous 0.5 mg dose, were investigated in two separate double-blind, placebo-controlled, period-balanced cross-over studies in healthy male subjects. Carvedilol increased the mean maximum plasma concentration and the area under the plasma concentration time-curve of digoxin when administered orally. The effects were virtually confined to the first 4 h after dosing, and the apparent terminal disposition rate constant was not changed. Carvedilol did not alter the plasma and urinary kinetics of intravenously administered digoxin." @default.
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- W2054874911 date "1990-04-01" @default.
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- W2054874911 title "Carvedilol increases the systemic bioavailability of oral digoxin." @default.
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- W2054874911 doi "https://doi.org/10.1111/j.1365-2125.1990.tb03668.x" @default.
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