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- W2054876475 abstract "Immunocytochemistry was used to determine whether (+/-)-fenfluramine causes structural damage to serotonergic (5-HT) neurons. Sections from rat forebrain were examined 4 h, 36 h and 2 weeks after various dose regimens of fenfluramine. At all time points there was a reduction of fine 5-HT axon terminals in the forebrain, while beaded axons were spared. The presence of markedly swollen, fragmented 5-HT axons 36 h after injection is indicative of axonal degeneration, and provides morphologic evidence for a neurotoxic effect of (+/-)-fenfluramine upon 5-HT axon terminals." @default.
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- W2054876475 date "1990-03-01" @default.
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- W2054876475 title "Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat" @default.
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- W2054876475 doi "https://doi.org/10.1016/0006-8993(90)90237-6" @default.
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