FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054879781> ?p ?o ?g. }

• W2054879781 abstract "The effect of ascorbic acid depletion on the 1-methyl-4-phenylpyridinium ion (MPP+)-induced neurotoxicity in the dopaminergic system has been tested in guinea-pig striatal slices. Guinea-pigs were divided into three groups and fed on a control diet, ascorbic acid-free diet and ascorbic acid-supplemented diet, respectively. Diets were maintained during 30 days. Striatal slices from ascorbic acid-deficient animals showed the highest levels of dopamine following 25 microM MPP+ treatment; the results from animals under this treatment condition were statistically different from both control and ascorbic acid-supplemented animals under identical experimental conditions. In addition, neurochemical analysis demonstrated that the levels of ascorbic acid and dehydroascorbic acid were highly reduced in striatal tissue from ascorbic acid-deficient animals, thus proving scorbutic conditions in our experimental animals. In view of the higher resistance of the ascorbic acid-deficient animals to the neurotoxicity elicited by MPP+, additional dopaminergic parameters were also measured in striatal tissue from ascorbic acid-deficient animals in the absence of MPP+, including levels of dopamine and its metabolites, tyrosine hydroxylase activity and dopamine uptake, with the aim of finding an explanation for this unexpected result. While dopamine levels and tyrosine hydroxylase activity remained close to control levels, dopamine uptake was significantly reduced in striatal synaptosomes from ascorbic acid-deficient animals as compared with control animals. Since MPP+ is actively accumulated into dopaminergic nerve terminals via the high-affinity dopamine uptake system, this finding could explain the higher resistance of ascorbic acid-deficient animals to the dopamine-depleting effect induced by MPP+ toxicity assayed in striatal slices." @default.
• W2054879781 created "2016-06-24" @default.
• W2054879781 creator A5019698136 @default.
• W2054879781 creator A5032384763 @default.
• W2054879781 creator A5036077377 @default.
• W2054879781 creator A5051823479 @default.
• W2054879781 creator A5056063773 @default.
• W2054879781 creator A5088461518 @default.
• W2054879781 date "1997-01-01" @default.
• W2054879781 modified "2023-10-01" @default.
• W2054879781 title "Less induced 1-methyl-4-phenylpyridinium ion neurotoxicity on striatal slices from guinea-pigs fed with a vitamin C-deficient diet" @default.
• W2054879781 cites W1775749144 @default.
• W2054879781 cites W1963964108 @default.
• W2054879781 cites W1969187334 @default.
• W2054879781 cites W1970318669 @default.
• W2054879781 cites W1974598209 @default.
• W2054879781 cites W1974735999 @default.
• W2054879781 cites W1981957141 @default.
• W2054879781 cites W1982626792 @default.
• W2054879781 cites W1988494297 @default.
• W2054879781 cites W1994980249 @default.
• W2054879781 cites W1997243628 @default.
• W2054879781 cites W1997910322 @default.
• W2054879781 cites W2002186719 @default.
• W2054879781 cites W2008204177 @default.
• W2054879781 cites W2023677185 @default.
• W2054879781 cites W2026881588 @default.
• W2054879781 cites W2028487608 @default.
• W2054879781 cites W2030257414 @default.
• W2054879781 cites W2038557175 @default.
• W2054879781 cites W2046063516 @default.
• W2054879781 cites W2054663416 @default.
• W2054879781 cites W2054677280 @default.
• W2054879781 cites W2056126212 @default.
• W2054879781 cites W2061984876 @default.
• W2054879781 cites W2062315181 @default.
• W2054879781 cites W2064313935 @default.
• W2054879781 cites W2072435070 @default.
• W2054879781 cites W2086455336 @default.
• W2054879781 cites W2087249096 @default.
• W2054879781 cites W2092384816 @default.
• W2054879781 cites W2094995555 @default.
• W2054879781 cites W2095792237 @default.
• W2054879781 cites W2111065594 @default.
• W2054879781 cites W2123355459 @default.
• W2054879781 cites W2125013402 @default.
• W2054879781 cites W2133451731 @default.
• W2054879781 cites W2145295139 @default.
• W2054879781 cites W2157052499 @default.
• W2054879781 cites W2164826175 @default.
• W2054879781 cites W2313541246 @default.
• W2054879781 cites W54933682 @default.
• W2054879781 doi "https://doi.org/10.1016/s0306-4522(96)00491-5" @default.
• W2054879781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9044384" @default.
• W2054879781 hasPublicationYear "1997" @default.
• W2054879781 type Work @default.
• W2054879781 sameAs 2054879781 @default.
• W2054879781 citedByCount "9" @default.
• W2054879781 crossrefType "journal-article" @default.
• W2054879781 hasAuthorship W2054879781A5019698136 @default.
• W2054879781 hasAuthorship W2054879781A5032384763 @default.
• W2054879781 hasAuthorship W2054879781A5036077377 @default.
• W2054879781 hasAuthorship W2054879781A5051823479 @default.
• W2054879781 hasAuthorship W2054879781A5056063773 @default.
• W2054879781 hasAuthorship W2054879781A5088461518 @default.
• W2054879781 hasConcept C126322002 @default.
• W2054879781 hasConcept C134018914 @default.
• W2054879781 hasConcept C137183658 @default.
• W2054879781 hasConcept C159167319 @default.
• W2054879781 hasConcept C185592680 @default.
• W2054879781 hasConcept C25876315 @default.
• W2054879781 hasConcept C2778815084 @default.
• W2054879781 hasConcept C2779211342 @default.
• W2054879781 hasConcept C2779491297 @default.
• W2054879781 hasConcept C2780022331 @default.
• W2054879781 hasConcept C2909345572 @default.
• W2054879781 hasConcept C29730261 @default.
• W2054879781 hasConcept C2986274086 @default.
• W2054879781 hasConcept C31903555 @default.
• W2054879781 hasConcept C513476851 @default.
• W2054879781 hasConcept C55493867 @default.
• W2054879781 hasConcept C71924100 @default.
• W2054879781 hasConcept C86803240 @default.
• W2054879781 hasConceptScore W2054879781C126322002 @default.
• W2054879781 hasConceptScore W2054879781C134018914 @default.
• W2054879781 hasConceptScore W2054879781C137183658 @default.
• W2054879781 hasConceptScore W2054879781C159167319 @default.
• W2054879781 hasConceptScore W2054879781C185592680 @default.
• W2054879781 hasConceptScore W2054879781C25876315 @default.
• W2054879781 hasConceptScore W2054879781C2778815084 @default.
• W2054879781 hasConceptScore W2054879781C2779211342 @default.
• W2054879781 hasConceptScore W2054879781C2779491297 @default.
• W2054879781 hasConceptScore W2054879781C2780022331 @default.
• W2054879781 hasConceptScore W2054879781C2909345572 @default.
• W2054879781 hasConceptScore W2054879781C29730261 @default.
• W2054879781 hasConceptScore W2054879781C2986274086 @default.
• W2054879781 hasConceptScore W2054879781C31903555 @default.
• W2054879781 hasConceptScore W2054879781C513476851 @default.
• W2054879781 hasConceptScore W2054879781C55493867 @default.
• W2054879781 hasConceptScore W2054879781C71924100 @default.

• next