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- W2054880213 endingPage "e69515" @default.
- W2054880213 startingPage "e69515" @default.
- W2054880213 abstract "Spinal cord injury triggers irreversible loss of motor and sensory functions. Numerous strategies aiming at repairing the injured spinal cord have been studied. Among them, the use of bone marrow-derived mesenchymal stem cells (BMSCs) is promising. Indeed, these cells possess interesting properties to modulate CNS environment and allow axon regeneration and functional recovery. Unfortunately, BMSC survival and differentiation within the host spinal cord remain poor, and these cells have been found to have various adverse effects when grafted in other pathological contexts. Moreover, paracrine-mediated actions have been proposed to explain the beneficial effects of BMSC transplantation after spinal cord injury. We thus decided to deliver BMSC-released factors to spinal cord injured rats and to study, in parallel, their properties in vitro. We show that, in vitro, BMSC-conditioned medium (BMSC-CM) protects neurons from apoptosis, activates macrophages and is pro-angiogenic. In vivo, BMSC-CM administered after spinal cord contusion improves motor recovery. Histological analysis confirms the pro-angiogenic action of BMSC-CM, as well as a tissue protection effect. Finally, the characterization of BMSC-CM by cytokine array and ELISA identified trophic factors as well as cytokines likely involved in the beneficial observed effects. In conclusion, our results support the paracrine-mediated mode of action of BMSCs and raise the possibility to develop a cell-free therapeutic approach." @default.
- W2054880213 created "2016-06-24" @default.
- W2054880213 creator A5012947573 @default.
- W2054880213 creator A5018653939 @default.
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- W2054880213 creator A5079098346 @default.
- W2054880213 creator A5084744120 @default.
- W2054880213 creator A5084988355 @default.
- W2054880213 date "2013-08-27" @default.
- W2054880213 modified "2023-10-08" @default.
- W2054880213 title "Conditioned Medium from Bone Marrow-Derived Mesenchymal Stem Cells Improves Recovery after Spinal Cord Injury in Rats: An Original Strategy to Avoid Cell Transplantation" @default.
- W2054880213 cites W1569061064 @default.
- W2054880213 cites W1608430181 @default.
- W2054880213 cites W1729010372 @default.
- W2054880213 cites W1777606123 @default.
- W2054880213 cites W1823435292 @default.
- W2054880213 cites W1895277992 @default.
- W2054880213 cites W1923266854 @default.
- W2054880213 cites W1963545508 @default.
- W2054880213 cites W1966672254 @default.
- W2054880213 cites W1968822973 @default.
- W2054880213 cites W1970024238 @default.
- W2054880213 cites W1971426179 @default.
- W2054880213 cites W1972229100 @default.
- W2054880213 cites W1972534236 @default.
- W2054880213 cites W1979476810 @default.
- W2054880213 cites W1979777131 @default.
- W2054880213 cites W1981287437 @default.
- W2054880213 cites W1981895579 @default.
- W2054880213 cites W1982192193 @default.
- W2054880213 cites W1982542580 @default.
- W2054880213 cites W1984807833 @default.
- W2054880213 cites W1986304142 @default.
- W2054880213 cites W1987174731 @default.
- W2054880213 cites W1991641152 @default.
- W2054880213 cites W1994791148 @default.
- W2054880213 cites W1998827792 @default.
- W2054880213 cites W2001216342 @default.
- W2054880213 cites W2004283213 @default.
- W2054880213 cites W2004445848 @default.
- W2054880213 cites W2006560625 @default.
- W2054880213 cites W2008415580 @default.
- W2054880213 cites W2008720843 @default.
- W2054880213 cites W2009245374 @default.
- W2054880213 cites W2009254352 @default.
- W2054880213 cites W2009321818 @default.
- W2054880213 cites W2013353419 @default.
- W2054880213 cites W2015246080 @default.
- W2054880213 cites W2015863843 @default.
- W2054880213 cites W2017850724 @default.
- W2054880213 cites W2020765082 @default.
- W2054880213 cites W2023316773 @default.
- W2054880213 cites W2029010189 @default.
- W2054880213 cites W2029531881 @default.
- W2054880213 cites W2030028037 @default.
- W2054880213 cites W2036487133 @default.
- W2054880213 cites W2038821886 @default.
- W2054880213 cites W2045701198 @default.
- W2054880213 cites W2046795216 @default.
- W2054880213 cites W2049192852 @default.
- W2054880213 cites W2049446122 @default.
- W2054880213 cites W2049893910 @default.
- W2054880213 cites W2051450207 @default.
- W2054880213 cites W2051990569 @default.
- W2054880213 cites W2054095354 @default.
- W2054880213 cites W2059244948 @default.
- W2054880213 cites W2060343680 @default.
- W2054880213 cites W2063709616 @default.
- W2054880213 cites W2069914873 @default.
- W2054880213 cites W2070877635 @default.
- W2054880213 cites W2073955194 @default.
- W2054880213 cites W2074908991 @default.
- W2054880213 cites W2075154721 @default.
- W2054880213 cites W2075288153 @default.
- W2054880213 cites W2079225903 @default.
- W2054880213 cites W2079915547 @default.
- W2054880213 cites W2080950947 @default.
- W2054880213 cites W2083469147 @default.
- W2054880213 cites W2084693500 @default.
- W2054880213 cites W2085628595 @default.
- W2054880213 cites W2086273881 @default.
- W2054880213 cites W2088190804 @default.
- W2054880213 cites W2093709488 @default.
- W2054880213 cites W2093738970 @default.
- W2054880213 cites W2096785977 @default.
- W2054880213 cites W2108602310 @default.
- W2054880213 cites W2110621821 @default.
- W2054880213 cites W2116850178 @default.
- W2054880213 cites W2124044470 @default.
- W2054880213 cites W2125774812 @default.
- W2054880213 cites W2132301122 @default.
- W2054880213 cites W2135378032 @default.
- W2054880213 cites W2139941185 @default.
- W2054880213 cites W2141815918 @default.
- W2054880213 cites W2144722561 @default.