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- W2054890503 abstract "Abstract The enzyme lactate dehydrogenase (LDH) was shown to exist as five electrophoretically distinct molecular varieties, or isozymes, within the tissues of the mouse. Nearly every tissue or organ of the adult mouse contains all five isozymes of LDH, but in proportions that are highly specific for the tissue. The pattern of isozyme distribution in embryonic tissues differs from the adult pattern. Most embryonic tissues initially contain principally LDH-5; as development proceeds LDH activity is gradually transposed toward the LDH-1 end of the spectrum. The LDH isozymes differ in kinetic properties, e.g., substrate concentration optima; these differences apparently enable the isozymes to fulfill distinct metabolic roles in cellular metabolism. LDH-5 is more abundant in tissues subject to relative anaerobiosis, and the isozymes at the other end of the spectrum are more abundant in highly oxygenated tissues. The isozyme patterns in the mouse are satisfactorily explained by the previously elaborated subunit hypothesis ( Markert, 1962 ), which pictures the LDH molecule as composed of four polypeptide subunits that may be separated into two distinct varieties, A and B, each presumably under the control of a separate gene. Assortment of these subunits in all possible combinations of four generates the five isozymes of LDH. The relative proportions of A and B synthesized by a cell would determine the tissue-specific patterns of LDH isozymes either in the adult or during the course of embryonic or neonatal development." @default.
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- W2054890503 date "1962-12-01" @default.
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- W2054890503 title "The ontogeny of isozyme patterns of lactate dehydrogenase in the mouse" @default.
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- W2054890503 doi "https://doi.org/10.1016/0012-1606(62)90019-2" @default.
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