FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054902011> ?p ?o ?g. }

• W2054902011 endingPage "1425" @default.
• W2054902011 startingPage "1419" @default.
• W2054902011 abstract "A multivariate statistical technique was applied to the design of an orally disintegrating tablet and to clarify the causal correlation among variables of the manufacturing process and pharmaceutical responses. Orally disintegrating tablets (ODTs) composed mainly of mannitol were prepared via the wet-granulation method using crystal transition from the δ to the β form of mannitol. Process parameters (water amounts (X1), kneading time (X2), compression force (X3), and amounts of magnesium stearate (X4)) were optimized using a nonlinear response surface method (RSM) incorporating a thin plate spline interpolation (RSM-S). The results of a verification study revealed that the experimental responses, such as tensile strength and disintegration time, coincided well with the predictions. A latent structure analysis of the pharmaceutical formulations of the tablet performed using a Bayesian network led to the clear visualization of a causal connection among variables of the manufacturing process and tablet characteristics. The quantity of β-mannitol in the granules (Qβ) was affected by X2 and influenced all granule properties. The specific surface area of the granules was affected by X1 and Qβ and had an effect on all tablet characteristics. Moreover, the causal relationships among the variables were clarified by inferring conditional probability distributions. These techniques provide a better understanding of the complicated latent structure among variables of the manufacturing process and tablet characteristics." @default.
• W2054902011 created "2016-06-24" @default.
• W2054902011 creator A5010760658 @default.
• W2054902011 creator A5024394826 @default.
• W2054902011 creator A5034680228 @default.
• W2054902011 creator A5035325664 @default.
• W2054902011 creator A5035882975 @default.
• W2054902011 creator A5042127136 @default.
• W2054902011 date "2012-01-01" @default.
• W2054902011 modified "2023-10-06" @default.
• W2054902011 title "Latent Structure Analysis of the Process Variables and Pharmaceutical Responses of an Orally Disintegrating Tablet" @default.
• W2054902011 cites W1530238563 @default.
• W2054902011 cites W1968126850 @default.
• W2054902011 cites W1973149628 @default.
• W2054902011 cites W1976898204 @default.
• W2054902011 cites W1980683029 @default.
• W2054902011 cites W1982814156 @default.
• W2054902011 cites W1991618236 @default.
• W2054902011 cites W1998005382 @default.
• W2054902011 cites W2009812515 @default.
• W2054902011 cites W2012722005 @default.
• W2054902011 cites W2019765848 @default.
• W2054902011 cites W2026134074 @default.
• W2054902011 cites W2027983230 @default.
• W2054902011 cites W2071678623 @default.
• W2054902011 cites W2149310258 @default.
• W2054902011 cites W2152194653 @default.
• W2054902011 cites W232408110 @default.
• W2054902011 cites W4236354166 @default.
• W2054902011 cites W4254332977 @default.
• W2054902011 doi "https://doi.org/10.1248/cpb.c12-00522" @default.
• W2054902011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22878814" @default.
• W2054902011 hasPublicationYear "2012" @default.
• W2054902011 type Work @default.
• W2054902011 sameAs 2054902011 @default.
• W2054902011 citedByCount "12" @default.
• W2054902011 countsByYear W20549020112013 @default.
• W2054902011 countsByYear W20549020112014 @default.
• W2054902011 countsByYear W20549020112015 @default.
• W2054902011 countsByYear W20549020112016 @default.
• W2054902011 countsByYear W20549020112018 @default.
• W2054902011 countsByYear W20549020112020 @default.
• W2054902011 countsByYear W20549020112023 @default.
• W2054902011 crossrefType "journal-article" @default.
• W2054902011 hasAuthorship W2054902011A5010760658 @default.
• W2054902011 hasAuthorship W2054902011A5024394826 @default.
• W2054902011 hasAuthorship W2054902011A5034680228 @default.
• W2054902011 hasAuthorship W2054902011A5035325664 @default.
• W2054902011 hasAuthorship W2054902011A5035882975 @default.
• W2054902011 hasAuthorship W2054902011A5042127136 @default.
• W2054902011 hasBestOaLocation W20549020111 @default.
• W2054902011 hasConcept C105795698 @default.
• W2054902011 hasConcept C147789679 @default.
• W2054902011 hasConcept C159985019 @default.
• W2054902011 hasConcept C185592680 @default.
• W2054902011 hasConcept C186060115 @default.
• W2054902011 hasConcept C187530423 @default.
• W2054902011 hasConcept C192562407 @default.
• W2054902011 hasConcept C2778572730 @default.
• W2054902011 hasConcept C2779849058 @default.
• W2054902011 hasConcept C2780449318 @default.
• W2054902011 hasConcept C33923547 @default.
• W2054902011 hasConcept C43617362 @default.
• W2054902011 hasConcept C49760210 @default.
• W2054902011 hasConcept C51167844 @default.
• W2054902011 hasConcept C77281830 @default.
• W2054902011 hasConcept C86803240 @default.
• W2054902011 hasConcept C88463166 @default.
• W2054902011 hasConceptScore W2054902011C105795698 @default.
• W2054902011 hasConceptScore W2054902011C147789679 @default.
• W2054902011 hasConceptScore W2054902011C159985019 @default.
• W2054902011 hasConceptScore W2054902011C185592680 @default.
• W2054902011 hasConceptScore W2054902011C186060115 @default.
• W2054902011 hasConceptScore W2054902011C187530423 @default.
• W2054902011 hasConceptScore W2054902011C192562407 @default.
• W2054902011 hasConceptScore W2054902011C2778572730 @default.
• W2054902011 hasConceptScore W2054902011C2779849058 @default.
• W2054902011 hasConceptScore W2054902011C2780449318 @default.
• W2054902011 hasConceptScore W2054902011C33923547 @default.
• W2054902011 hasConceptScore W2054902011C43617362 @default.
• W2054902011 hasConceptScore W2054902011C49760210 @default.
• W2054902011 hasConceptScore W2054902011C51167844 @default.
• W2054902011 hasConceptScore W2054902011C77281830 @default.
• W2054902011 hasConceptScore W2054902011C86803240 @default.
• W2054902011 hasConceptScore W2054902011C88463166 @default.
• W2054902011 hasIssue "11" @default.
• W2054902011 hasLocation W20549020111 @default.
• W2054902011 hasLocation W20549020112 @default.
• W2054902011 hasOpenAccess W2054902011 @default.
• W2054902011 hasPrimaryLocation W20549020111 @default.
• W2054902011 hasRelatedWork W1980971399 @default.
• W2054902011 hasRelatedWork W2037311911 @default.
• W2054902011 hasRelatedWork W2054902011 @default.
• W2054902011 hasRelatedWork W2182569004 @default.
• W2054902011 hasRelatedWork W2802759018 @default.
• W2054902011 hasRelatedWork W3096322573 @default.
• W2054902011 hasRelatedWork W4220814943 @default.
• W2054902011 hasRelatedWork W4312932808 @default.

• next