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- W2054908654 abstract "The prevalence of asthma, in particular atopic asthma, has markedly increased in recent years. Accumulating evidence suggests that environmental factors associated with allergic sensitization and exposure to microbial stimuli during infancy and early childhood, are associated with these changes in prevalence. However, considerable controversy surrounds the role of microbial agents, as evidence has been presented for both positive and negative effects in this context. The review below focuses upon interactions between immune competence during infancy, the development of T-helper (Th)1-polarized versus Th2-polarized memory against inhalant allergens, and susceptibility to virus infection. In particular, recent finding are highlighted which suggest that delayed postnatal maturation of Th1 function is associated with increased risk for early postnatal sensitization to inhalant allergens, and also with risk for viral bronchiolitis during infancy. Variations in the kinetics of postnatal maturation of T-helper 1 function may in part be attributable to polymorphisms in the CD14 gene, which influence host responsiveness both to bacterial as well as viral stimuli." @default.
- W2054908654 created "2016-06-24" @default.
- W2054908654 creator A5048175603 @default.
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- W2054908654 date "2002-03-01" @default.
- W2054908654 modified "2023-10-18" @default.
- W2054908654 title "Interactions between respiratory tract infections and atopy in the aetiology of asthma" @default.
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- W2054908654 doi "https://doi.org/10.1183/09031936.02.00229302" @default.
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