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- W2054915931 abstract "Objective: Recently it has been reported that human endometrium expresses FAS-Ligand during secretory phase and in the decidua. Furthermore, trophoblast expresses Fas and Fas Ligand. Apoptosis has been found in the syncithyum trophoblast during all pregnancy. We studied in the same pregnant decidual tissues, the expression of FAS, FAS-Ligand and the presence of apoptosis both in trophoblast and endometrial component. Design: Apoptosis by TUNEL and the expression of FAS and Fas-Ligand by immunohistochemestry in decidual tissue and trophoblast in first trimester pregnancy were studied. Materials/Methods: We evaluated tissue specimens of first trimester decidua and trophoblast obtained from 15 pregnant women underwent voluntary abortion. The specimens of decidual tissue were fixed in formalin overnight and paraffin embedded. The indirect avidin-biotin complex (Vectastin ABC-peroxidase kit) immunoperoxidase assay and the TUNEL assay were performed on de-waxed and re-hydrated 5nm thick sections of 10%. Anti-Fas-Receptor monoclonal antibodies and anti-FAS-Ligand poly-clonal primary rabbit antibody with a 1:50 dilution phosphate-buffered solution were used. The anti-mouse and anti-rabbit serum were used as second antibody. The Vectastain ABC-peroxidase (Vector USA) was used for immunocytochemical localization. Staining was developed using 1.7nM 3.3 diaminobenzidine and 0.05% hydrogen peroxidase. Results: In the trophoblast villi apoptosis was observed in the syncithyum trophoblast especially in syncithial knots and in the same component the expression of Fas. The apoptosis ratio was 0.018+0.0008 in syncithyum trophoblast. In the epithelial cells of decidua FAS-L was strongly expressed especially in the regions close to villis. Conclusions: The presence of apoptosis in syncithyum trophoblast with the concomitant expression of Fas in the same cells whereas the strong expression of Fas-Ligand in the epithelial cells of decidua seem to show that Fas/Fas-Ligand system regulates and limits the invasion of trophoblast inducing apoptosis. Supported by: None." @default.
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- W2054915931 date "2002-09-01" @default.
- W2054915931 modified "2023-09-28" @default.
- W2054915931 title "Fas-Fas ligand system regulates invasiveness of trophoblast in first trimester pregnancy" @default.
- W2054915931 doi "https://doi.org/10.1016/s0015-0282(02)03848-7" @default.
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