Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054920996> ?p ?o ?g. }
- W2054920996 endingPage "1115" @default.
- W2054920996 startingPage "1108" @default.
- W2054920996 abstract "p51/p63 gene, one of the p53 families, is specifically expressed in tooth germ epithelial cells and is essential for tooth development. This study aims to elucidate roles of p51/p63 in ameloblastic cell differentiation.We determined expression pattern of each of p51/p63 isoforms by reverse transcriptase-polymerase chain reaction (RT-PCR) and western blotting using emtg (epithelium of molar tooth germ)-1, -2, -3, -4, and -5 cell lines established from a mandibular molar tooth germ of p53-deficient mice and SF2 cells which differentiates into ameloblasts upon exposure to NT4. Furthermore, we investigated the function of p51/p63 in these cells by Tet system, which enables inducible expression and knock down of the target genes of interest by exposing cells to doxycycline.The expression of ΔNp51B/ΔNp63α, an isoform without transactivation domain, was detected at high level in immature cells, while the expression of TAp51/TAp63 isoforms, isoforms of with the transactivation domain, was detected at high level in mature cells. Moreover, induction of TAp51A/TAp63γ expression led to down-regulation of ΔNp51B/ΔNp63α expression and cell proliferation. Interestingly, this also led to up-regulation of ameloblastin expression, a differentiation marker of amelogenesis.The results suggested that p51/p63 might regulate the cell proliferation and differentiation of tooth germ epithelial cells." @default.
- W2054920996 created "2016-06-24" @default.
- W2054920996 creator A5015016383 @default.
- W2054920996 creator A5026856725 @default.
- W2054920996 creator A5034772950 @default.
- W2054920996 creator A5059219079 @default.
- W2054920996 creator A5066214269 @default.
- W2054920996 creator A5074502144 @default.
- W2054920996 date "2012-08-01" @default.
- W2054920996 modified "2023-10-16" @default.
- W2054920996 title "Regulation of proliferation and differentiation of mouse tooth germ epithelial cells by distinct isoforms of p51/p63" @default.
- W2054920996 cites W1501825044 @default.
- W2054920996 cites W1534987406 @default.
- W2054920996 cites W1581569435 @default.
- W2054920996 cites W1975410010 @default.
- W2054920996 cites W1978551650 @default.
- W2054920996 cites W1981700349 @default.
- W2054920996 cites W1986285972 @default.
- W2054920996 cites W1989424867 @default.
- W2054920996 cites W2000854021 @default.
- W2054920996 cites W2005275397 @default.
- W2054920996 cites W2014938226 @default.
- W2054920996 cites W2016840856 @default.
- W2054920996 cites W2020272971 @default.
- W2054920996 cites W2023332224 @default.
- W2054920996 cites W2038977882 @default.
- W2054920996 cites W2047490113 @default.
- W2054920996 cites W2054052732 @default.
- W2054920996 cites W2056691444 @default.
- W2054920996 cites W2059222716 @default.
- W2054920996 cites W2060823106 @default.
- W2054920996 cites W2062364714 @default.
- W2054920996 cites W2063156985 @default.
- W2054920996 cites W2065735330 @default.
- W2054920996 cites W2068223241 @default.
- W2054920996 cites W2069144282 @default.
- W2054920996 cites W2069805994 @default.
- W2054920996 cites W2071150291 @default.
- W2054920996 cites W2074222004 @default.
- W2054920996 cites W2079477526 @default.
- W2054920996 cites W2081144106 @default.
- W2054920996 cites W2088744498 @default.
- W2054920996 cites W2103785126 @default.
- W2054920996 cites W2104244397 @default.
- W2054920996 cites W2108249958 @default.
- W2054920996 cites W2122748292 @default.
- W2054920996 cites W2128092377 @default.
- W2054920996 cites W2132594991 @default.
- W2054920996 cites W2138786316 @default.
- W2054920996 cites W2139595069 @default.
- W2054920996 cites W2149214251 @default.
- W2054920996 cites W2151845504 @default.
- W2054920996 cites W2152084578 @default.
- W2054920996 cites W2156999957 @default.
- W2054920996 cites W2159199900 @default.
- W2054920996 cites W2166476348 @default.
- W2054920996 cites W2170216427 @default.
- W2054920996 cites W4256249048 @default.
- W2054920996 doi "https://doi.org/10.1016/j.archoralbio.2012.02.023" @default.
- W2054920996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22440406" @default.
- W2054920996 hasPublicationYear "2012" @default.
- W2054920996 type Work @default.
- W2054920996 sameAs 2054920996 @default.
- W2054920996 citedByCount "5" @default.
- W2054920996 countsByYear W20549209962013 @default.
- W2054920996 countsByYear W20549209962016 @default.
- W2054920996 countsByYear W20549209962018 @default.
- W2054920996 countsByYear W20549209962019 @default.
- W2054920996 crossrefType "journal-article" @default.
- W2054920996 hasAuthorship W2054920996A5015016383 @default.
- W2054920996 hasAuthorship W2054920996A5026856725 @default.
- W2054920996 hasAuthorship W2054920996A5034772950 @default.
- W2054920996 hasAuthorship W2054920996A5059219079 @default.
- W2054920996 hasAuthorship W2054920996A5066214269 @default.
- W2054920996 hasAuthorship W2054920996A5074502144 @default.
- W2054920996 hasConcept C104317684 @default.
- W2054920996 hasConcept C104392178 @default.
- W2054920996 hasConcept C1292079 @default.
- W2054920996 hasConcept C148738053 @default.
- W2054920996 hasConcept C150194340 @default.
- W2054920996 hasConcept C156887251 @default.
- W2054920996 hasConcept C199343813 @default.
- W2054920996 hasConcept C2779122487 @default.
- W2054920996 hasConcept C53345823 @default.
- W2054920996 hasConcept C54355233 @default.
- W2054920996 hasConcept C62112901 @default.
- W2054920996 hasConcept C71924100 @default.
- W2054920996 hasConcept C86803240 @default.
- W2054920996 hasConcept C95444343 @default.
- W2054920996 hasConceptScore W2054920996C104317684 @default.
- W2054920996 hasConceptScore W2054920996C104392178 @default.
- W2054920996 hasConceptScore W2054920996C1292079 @default.
- W2054920996 hasConceptScore W2054920996C148738053 @default.
- W2054920996 hasConceptScore W2054920996C150194340 @default.
- W2054920996 hasConceptScore W2054920996C156887251 @default.
- W2054920996 hasConceptScore W2054920996C199343813 @default.
- W2054920996 hasConceptScore W2054920996C2779122487 @default.
- W2054920996 hasConceptScore W2054920996C53345823 @default.