FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054938015> ?p ?o ?g. }

• W2054938015 endingPage "52" @default.
• W2054938015 startingPage "43" @default.
• W2054938015 abstract "Energy restriction (ER) causes metabolic improvement in the prediabetic and diabetic state. Little information exists on the mechanism of action of ER, for example, on the changes at the transcriptional gene level in insulin-sensitive tissues. To gain further insight, we have investigated changes in gene expressions in skeletal muscle, liver, fat, and pancreatic islets after ER in male Zucker diabetic fatty rats. Eighteen Zucker diabetic fatty rats were divided at the age of 7 weeks into a control group (ad libitum diet) and an ER group (30% ER compared with the control group). Blood glucose, weight, and food intake were measured weekly. After 5 weeks, blood samples, and skeletal muscle, liver, visceral fat (epididymal fat pads), and islets tissue were collected. Gene expression was quantified with high-density oligonucleotide, microarray GeneChip technology. ER ameliorated the development of hyperglycemia, increased the levels of plasma insulin, and reduced plasma total cholesterol and the glucagon-insulin ratio (P < .05). In skeletal muscle, the expression of 55 genes increased and 245 decreased involving genes related to glucose metabolism (eg, phosphorylase kinase, pyruvate dehydrogenase kinase 4), lipid metabolism (eg, carnitine palmitoyltransferase 1, fatty acid transporter), and signaling pathways (eg, mitogen-activated protein kinases, protein kinase C). In the liver, the expression of 123 genes increased and 103 decreased involving genes related primarily to lipid metabolism. In pancreatic islets, the expression of 110 genes increased and that of 127 decreased, whereas in visceral fat, the expression of 279 genes increased and that of 528 decreased. ER counteracts the development of diabetes and causes changes in the expression of multiple genes involved in glucose and lipid metabolism in skeletal muscle, liver, and pancreatic islets, which may play an important role for the prevention of diabetes." @default.
• W2054938015 created "2016-06-24" @default.
• W2054938015 creator A5014285107 @default.
• W2054938015 creator A5020762430 @default.
• W2054938015 creator A5030978847 @default.
• W2054938015 creator A5036036630 @default.
• W2054938015 creator A5063015855 @default.
• W2054938015 creator A5078948022 @default.
• W2054938015 creator A5088641715 @default.
• W2054938015 date "2006-01-01" @default.
• W2054938015 modified "2023-09-28" @default.
• W2054938015 title "Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysis" @default.
• W2054938015 cites W1529592271 @default.
• W2054938015 cites W1594655861 @default.
• W2054938015 cites W1818080689 @default.
• W2054938015 cites W1828498691 @default.
• W2054938015 cites W1910780539 @default.
• W2054938015 cites W1971945315 @default.
• W2054938015 cites W1981010609 @default.
• W2054938015 cites W1992052690 @default.
• W2054938015 cites W2008699478 @default.
• W2054938015 cites W2009818179 @default.
• W2054938015 cites W2012567315 @default.
• W2054938015 cites W2013830975 @default.
• W2054938015 cites W2022986290 @default.
• W2054938015 cites W2025925264 @default.
• W2054938015 cites W2026703925 @default.
• W2054938015 cites W2041772085 @default.
• W2054938015 cites W2048918009 @default.
• W2054938015 cites W2050277889 @default.
• W2054938015 cites W2052613838 @default.
• W2054938015 cites W2056860785 @default.
• W2054938015 cites W2065660771 @default.
• W2054938015 cites W2067349705 @default.
• W2054938015 cites W2067564236 @default.
• W2054938015 cites W2072533524 @default.
• W2054938015 cites W2076036291 @default.
• W2054938015 cites W2083990676 @default.
• W2054938015 cites W2085848694 @default.
• W2054938015 cites W2093644864 @default.
• W2054938015 cites W2096706659 @default.
• W2054938015 cites W2097558464 @default.
• W2054938015 cites W2097784879 @default.
• W2054938015 cites W2098140413 @default.
• W2054938015 cites W2116440960 @default.
• W2054938015 cites W2116466073 @default.
• W2054938015 cites W2118087664 @default.
• W2054938015 cites W2118659478 @default.
• W2054938015 cites W2119390770 @default.
• W2054938015 cites W2123521914 @default.
• W2054938015 cites W2129803878 @default.
• W2054938015 cites W2140609968 @default.
• W2054938015 cites W2144699106 @default.
• W2054938015 cites W2150534781 @default.
• W2054938015 cites W2153392081 @default.
• W2054938015 cites W2157865424 @default.
• W2054938015 cites W2158075769 @default.
• W2054938015 cites W2158822657 @default.
• W2054938015 cites W2313589149 @default.
• W2054938015 cites W2332951586 @default.
• W2054938015 cites W2430143578 @default.
• W2054938015 cites W4254261652 @default.
• W2054938015 doi "https://doi.org/10.1016/j.metabol.2005.07.005" @default.
• W2054938015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16324918" @default.
• W2054938015 hasPublicationYear "2006" @default.
• W2054938015 type Work @default.
• W2054938015 sameAs 2054938015 @default.
• W2054938015 citedByCount "26" @default.
• W2054938015 countsByYear W20549380152013 @default.
• W2054938015 countsByYear W20549380152014 @default.
• W2054938015 countsByYear W20549380152016 @default.
• W2054938015 countsByYear W20549380152017 @default.
• W2054938015 countsByYear W20549380152018 @default.
• W2054938015 countsByYear W20549380152019 @default.
• W2054938015 countsByYear W20549380152020 @default.
• W2054938015 countsByYear W20549380152021 @default.
• W2054938015 crossrefType "journal-article" @default.
• W2054938015 hasAuthorship W2054938015A5014285107 @default.
• W2054938015 hasAuthorship W2054938015A5020762430 @default.
• W2054938015 hasAuthorship W2054938015A5030978847 @default.
• W2054938015 hasAuthorship W2054938015A5036036630 @default.
• W2054938015 hasAuthorship W2054938015A5063015855 @default.
• W2054938015 hasAuthorship W2054938015A5078948022 @default.
• W2054938015 hasAuthorship W2054938015A5088641715 @default.
• W2054938015 hasConcept C126322002 @default.
• W2054938015 hasConcept C134018914 @default.
• W2054938015 hasConcept C165220095 @default.
• W2054938015 hasConcept C17093226 @default.
• W2054938015 hasConcept C2778435403 @default.
• W2054938015 hasConcept C2779306644 @default.
• W2054938015 hasConcept C2779855799 @default.
• W2054938015 hasConcept C4733338 @default.
• W2054938015 hasConcept C555293320 @default.
• W2054938015 hasConcept C71924100 @default.
• W2054938015 hasConcept C86803240 @default.
• W2054938015 hasConceptScore W2054938015C126322002 @default.
• W2054938015 hasConceptScore W2054938015C134018914 @default.
• W2054938015 hasConceptScore W2054938015C165220095 @default.

• next