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- W2054947823 abstract "This study examined the antinociceptive effects of seven imidazoline I2 receptor ligands in a rat warm water tail withdrawal procedure (46 and 50°C). Agmatine, 2-BFI, phenyzoline, and diphenyzoline produced a significant antinociceptive activity at 46°C. BU224, S22687, and idazoxan had no effect at 46°C up to doses that altered the locomotor activity. None of the drugs showed antinociceptive activity at 50°C. It is suggested that I2 receptor agonists have antinociceptive activity for acute phasic pain under weak noxious stimulus, and the effects are efficacy-dependent. These data explain the findings that I2 receptor agonists enhance the antinociceptive effects of opioids and support developing higher-efficacy I2 receptor agonists for the treatment of pain." @default.
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- W2054947823 date "2012-01-25" @default.
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- W2054947823 title "Effects of imidazoline I2 receptor ligands on acute nociception in rats" @default.
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- W2054947823 doi "https://doi.org/10.1097/wnr.0b013e32834e7db3" @default.
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