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• W2054954966 abstract "The heterotrimeric enzyme AMP-activated protein kinase (AMPK) is a major metabolic factor that regulates the homeostasis of cellular energy. In particular, AMPK mediates the insulin resistance that is associated with type 2 diabetes. Generally, cellular processes require tight regulation of protein kinases, which is effected through their formation of complex with other proteins and substrates. Despite their critical function in regulation and pathogenesis, there are limited data on the interaction of protein kinases. To identify proteins that interact with AMPK, we performed large-scale affinity purification (AP)-mass spectrometry (MS) of the AMPK-α1 and -β1 subunits. Through a comprehensive analysis, using a combination of immunoprecipitaion and ion trap mass spectrometry, we identified 381 unique proteins in the AMPKα/β interactomes: 325 partners of AMPK-α1 and 243 for AMPK-β1. Further, we identified 196 novel protein-protein interactions with AMPK-α1 and AMPK-β1. Notably, in our bioinformatics analysis, the novel interaction partners mediated functions that are related to the regulation of actin organization. Specifically, several such proteins were linked to pancreatic beta-cell functions, including glucose-stimulated insulin secretion, beta-cell development, beta-cell differentiation, and cell-cell communication." @default.
• W2054954966 created "2016-06-24" @default.
• W2054954966 creator A5022694995 @default.
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• W2054954966 creator A5086675314 @default.
• W2054954966 creator A5089590792 @default.
• W2054954966 date "2014-03-14" @default.
• W2054954966 modified "2023-10-13" @default.
• W2054954966 title "Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry" @default.
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• W2054954966 cites W1810821938 @default.
• W2054954966 cites W1967667786 @default.
• W2054954966 cites W1970205234 @default.
• W2054954966 cites W1970432663 @default.
• W2054954966 cites W1978891398 @default.
• W2054954966 cites W1979656912 @default.
• W2054954966 cites W1982555128 @default.
• W2054954966 cites W1986656413 @default.
• W2054954966 cites W1995989434 @default.
• W2054954966 cites W1996458818 @default.
• W2054954966 cites W1998884444 @default.
• W2054954966 cites W2000860171 @default.
• W2054954966 cites W2002800164 @default.
• W2054954966 cites W2003206984 @default.
• W2054954966 cites W2004814508 @default.
• W2054954966 cites W2010282670 @default.
• W2054954966 cites W2010518291 @default.
• W2054954966 cites W2010768245 @default.
• W2054954966 cites W2014670133 @default.
• W2054954966 cites W2015501861 @default.
• W2054954966 cites W2022630818 @default.
• W2054954966 cites W2027980594 @default.
• W2054954966 cites W2030029307 @default.
• W2054954966 cites W2033004791 @default.
• W2054954966 cites W2034210044 @default.
• W2054954966 cites W2035542044 @default.
• W2054954966 cites W2037006420 @default.
• W2054954966 cites W2037036397 @default.
• W2054954966 cites W2037199116 @default.
• W2054954966 cites W2037922295 @default.
• W2054954966 cites W2043498277 @default.
• W2054954966 cites W2045373134 @default.
• W2054954966 cites W2047077861 @default.
• W2054954966 cites W2048839385 @default.
• W2054954966 cites W2054094290 @default.
• W2054954966 cites W2065080656 @default.
• W2054954966 cites W2067136301 @default.
• W2054954966 cites W2067979493 @default.
• W2054954966 cites W2074284424 @default.
• W2054954966 cites W2074874413 @default.
• W2054954966 cites W2074894911 @default.
• W2054954966 cites W2075167858 @default.
• W2054954966 cites W2081920342 @default.
• W2054954966 cites W2088425779 @default.
• W2054954966 cites W2091685838 @default.
• W2054954966 cites W2096687482 @default.
• W2054954966 cites W2099278991 @default.
• W2054954966 cites W2104109084 @default.
• W2054954966 cites W2104726963 @default.
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• W2054954966 cites W2126032145 @default.
• W2054954966 cites W2126931729 @default.
• W2054954966 cites W2128036243 @default.
• W2054954966 cites W2128308759 @default.
• W2054954966 cites W2134866534 @default.
• W2054954966 cites W2135362510 @default.
• W2054954966 cites W2140638448 @default.
• W2054954966 cites W2145368725 @default.
• W2054954966 cites W2146788325 @default.
• W2054954966 cites W2147956857 @default.
• W2054954966 cites W2155521690 @default.
• W2054954966 cites W2157658519 @default.
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• W2054954966 cites W2162122379 @default.
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• W2054954966 doi "https://doi.org/10.1038/srep04376" @default.
• W2054954966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3953747" @default.
• W2054954966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24625528" @default.
• W2054954966 hasPublicationYear "2014" @default.
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