Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054958817> ?p ?o ?g. }
- W2054958817 endingPage "327" @default.
- W2054958817 startingPage "320" @default.
- W2054958817 abstract "Introduction An association between an increase in plasminogen activator inhibitor type 1 and obesity has been described. It has also been shown that a decrease in adiposity has beneficial effects. However, less information is available regarding morbid obesity and hypofibrinolysis. The aim of the present study was to evaluate the effect of weight loss and the influence of the plasminogen activator inhibitor type 1 promoter 4G/5G genotype on plasminogen activator inhibitor type 1 levels in severe and morbid obesity. Materials and methods Sixty-seven obese patients were studied before and three months after a weight reduction program, and compared with 67 controls. We determined plasminogen activator inhibitor type 1 antigen and activity levels, tissue type plasminogen activator antigen levels, 4G/5G genotype and biochemical parameters in both groups. Results A significant increase in plasminogen activator inhibitor type 1 antigen and activity was observed in obese patients in comparison with the control group (P<0.001). No significant differences in plasminogen activator inhibitor type 1 levels among 4G/5G genotypes were obtained. After weight loss, a significant decrease in plasminogen activator inhibitor type 1 antigen and activity was observed (P<0.001). A significant and positive correlation was observed in percentage changes in plasminogen activator inhibitor type 1 and body mass index (P=0.02). Conclusions A decrease in body mass index in severe and morbid obesity shows a favourable effect on the fibrinolytic system due to a decrease in plasminogen activator inhibitor type 1 levels. However, no influence of 4G/5G polymorphism has been observed in this setting." @default.
- W2054958817 created "2016-06-24" @default.
- W2054958817 creator A5012145074 @default.
- W2054958817 creator A5029685260 @default.
- W2054958817 creator A5033392955 @default.
- W2054958817 creator A5057986151 @default.
- W2054958817 creator A5060500684 @default.
- W2054958817 creator A5068695724 @default.
- W2054958817 creator A5078810076 @default.
- W2054958817 creator A5079018683 @default.
- W2054958817 date "2008-01-01" @default.
- W2054958817 modified "2023-10-11" @default.
- W2054958817 title "Plasminogen activator inhibitor-1 levels in severe and morbid obesity. Effect of weight loss and influence of 4G/5G polymorphism" @default.
- W2054958817 cites W1505365469 @default.
- W2054958817 cites W1517176433 @default.
- W2054958817 cites W1846905620 @default.
- W2054958817 cites W1964018654 @default.
- W2054958817 cites W1968549341 @default.
- W2054958817 cites W1989578541 @default.
- W2054958817 cites W1996828964 @default.
- W2054958817 cites W1997857914 @default.
- W2054958817 cites W2004260519 @default.
- W2054958817 cites W2005846426 @default.
- W2054958817 cites W2012273417 @default.
- W2054958817 cites W2017443789 @default.
- W2054958817 cites W2019203967 @default.
- W2054958817 cites W2023560671 @default.
- W2054958817 cites W2023752959 @default.
- W2054958817 cites W2033958201 @default.
- W2054958817 cites W2052794493 @default.
- W2054958817 cites W2062992374 @default.
- W2054958817 cites W2069303847 @default.
- W2054958817 cites W2069759393 @default.
- W2054958817 cites W2085680837 @default.
- W2054958817 cites W2095107524 @default.
- W2054958817 cites W2099611273 @default.
- W2054958817 cites W2104060102 @default.
- W2054958817 cites W2104858407 @default.
- W2054958817 cites W2109010768 @default.
- W2054958817 cites W2109584355 @default.
- W2054958817 cites W2113347357 @default.
- W2054958817 cites W2124087935 @default.
- W2054958817 cites W2134059227 @default.
- W2054958817 cites W2136961309 @default.
- W2054958817 cites W2142916749 @default.
- W2054958817 cites W2156213523 @default.
- W2054958817 cites W2160234571 @default.
- W2054958817 cites W2162364543 @default.
- W2054958817 cites W2194992135 @default.
- W2054958817 cites W2410467855 @default.
- W2054958817 cites W2411331373 @default.
- W2054958817 cites W2413129925 @default.
- W2054958817 cites W2416232791 @default.
- W2054958817 cites W3150343929 @default.
- W2054958817 cites W4376542864 @default.
- W2054958817 cites W1970111556 @default.
- W2054958817 doi "https://doi.org/10.1016/j.thromres.2007.10.016" @default.
- W2054958817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18037477" @default.
- W2054958817 hasPublicationYear "2008" @default.
- W2054958817 type Work @default.
- W2054958817 sameAs 2054958817 @default.
- W2054958817 citedByCount "27" @default.
- W2054958817 countsByYear W20549588172012 @default.
- W2054958817 countsByYear W20549588172013 @default.
- W2054958817 countsByYear W20549588172015 @default.
- W2054958817 countsByYear W20549588172016 @default.
- W2054958817 countsByYear W20549588172017 @default.
- W2054958817 countsByYear W20549588172018 @default.
- W2054958817 countsByYear W20549588172019 @default.
- W2054958817 countsByYear W20549588172020 @default.
- W2054958817 countsByYear W20549588172021 @default.
- W2054958817 countsByYear W20549588172022 @default.
- W2054958817 crossrefType "journal-article" @default.
- W2054958817 hasAuthorship W2054958817A5012145074 @default.
- W2054958817 hasAuthorship W2054958817A5029685260 @default.
- W2054958817 hasAuthorship W2054958817A5033392955 @default.
- W2054958817 hasAuthorship W2054958817A5057986151 @default.
- W2054958817 hasAuthorship W2054958817A5060500684 @default.
- W2054958817 hasAuthorship W2054958817A5068695724 @default.
- W2054958817 hasAuthorship W2054958817A5078810076 @default.
- W2054958817 hasAuthorship W2054958817A5079018683 @default.
- W2054958817 hasConcept C104317684 @default.
- W2054958817 hasConcept C126322002 @default.
- W2054958817 hasConcept C134018914 @default.
- W2054958817 hasConcept C135763542 @default.
- W2054958817 hasConcept C185592680 @default.
- W2054958817 hasConcept C2776572282 @default.
- W2054958817 hasConcept C2779679481 @default.
- W2054958817 hasConcept C2780221984 @default.
- W2054958817 hasConcept C2780675426 @default.
- W2054958817 hasConcept C511355011 @default.
- W2054958817 hasConcept C55493867 @default.
- W2054958817 hasConcept C71924100 @default.
- W2054958817 hasConceptScore W2054958817C104317684 @default.
- W2054958817 hasConceptScore W2054958817C126322002 @default.
- W2054958817 hasConceptScore W2054958817C134018914 @default.
- W2054958817 hasConceptScore W2054958817C135763542 @default.
- W2054958817 hasConceptScore W2054958817C185592680 @default.