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• W2054985391 abstract "Cooperative modulation of [3H]MK-801 binding to extensively washed pig cortical brain membranes in the presence of various concentrations of L-glutamate, glycine, spermine, CPP and DCKA was evaluated in association experiments. In saturation experiments [3H]MK-801 labelled a homogeneous population of binding sites with a Kd-value of 1.26 +/- 0.18 nmol 1(-1) and a Bmax-value of 2130 +/- 200 fmol/mg protein. The pharmacological profile of this site was further evaluated in competition experiments with known NMDA receptor channel blockers. In nonequilibrium binding experiments EC50-values of reference compounds acting at the L-glutamate, at the glycine, and at the polyamine site, were determined by increasing or decreasing [3H]MK-801 binding. Ifenprodil reduced [3H]MK-801 binding in a biphasic manner. All the data obtained are in agreement with results from [3H]MK-801 binding to rodent as well as human brain membranes. This study therefore strongly suggests, that pig cortical membranes are a suitable alternative to rodent brain membranes, and an acceptable substitute for human brain membranes in [3H]MK-801 binding experiments." @default.
• W2054985391 created "2016-06-24" @default.
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• W2054985391 date "1996-01-01" @default.
• W2054985391 modified "2023-09-23" @default.
• W2054985391 title "Characterisation of [³H]MK-801 Binding and its Cooperative Modulation by PIG Brain Membranes" @default.
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• W2054985391 doi "https://doi.org/10.3109/10799899609039953" @default.
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