Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054991824> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2054991824 endingPage "878" @default.
- W2054991824 startingPage "875" @default.
- W2054991824 abstract "One of the main goals for toxicologists working on the development of in vitro tests is to replace the animal-based eye irritation test. Inflammation is one of the mechanisms which have not been covered sufficiently by the existing in vitro ocular irritancy test systems. As there are major species differences between the human and rabbit eye inflammation mechanisms, the most relevant test system is the human eye itself. The current study focused on an evaluation of the practical availability of human corneal epithelial cells for routine eye irritancy testing. Human corneal epithelium cell cultures were used to assess the effects of lipopolysaccharide on IL-1β release. The findings indicated that cytokine release can be augmented by the presence of the complement system, which is normally found in tears. However, the corneal cells were found to be highly resistant to the complement system, which can be attributed to the very high expression of CD59, a powerful complement regulatory protein found in the corneal epithelium. It is estimated that discarded corneas from tissue banks could provide enough material for routine testing by this method." @default.
- W2054991824 created "2016-06-24" @default.
- W2054991824 creator A5010370364 @default.
- W2054991824 creator A5032094148 @default.
- W2054991824 creator A5033369556 @default.
- W2054991824 creator A5064491755 @default.
- W2054991824 creator A5069820176 @default.
- W2054991824 creator A5077484679 @default.
- W2054991824 date "2005-10-01" @default.
- W2054991824 modified "2023-09-27" @default.
- W2054991824 title "Culture of the primary corneal epithelium as a potential component of test batteries for eye irritancy testing" @default.
- W2054991824 cites W127988399 @default.
- W2054991824 cites W155277747 @default.
- W2054991824 cites W1600038678 @default.
- W2054991824 cites W1969008225 @default.
- W2054991824 cites W1981013532 @default.
- W2054991824 cites W2009661740 @default.
- W2054991824 cites W2010071242 @default.
- W2054991824 cites W2036084778 @default.
- W2054991824 cites W2080754765 @default.
- W2054991824 cites W2101302622 @default.
- W2054991824 cites W2138865776 @default.
- W2054991824 cites W2237031903 @default.
- W2054991824 cites W2417300099 @default.
- W2054991824 cites W581033514 @default.
- W2054991824 doi "https://doi.org/10.1016/j.tiv.2005.06.028" @default.
- W2054991824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16061345" @default.
- W2054991824 hasPublicationYear "2005" @default.
- W2054991824 type Work @default.
- W2054991824 sameAs 2054991824 @default.
- W2054991824 citedByCount "7" @default.
- W2054991824 countsByYear W20549918242012 @default.
- W2054991824 countsByYear W20549918242013 @default.
- W2054991824 countsByYear W20549918242015 @default.
- W2054991824 countsByYear W20549918242018 @default.
- W2054991824 crossrefType "journal-article" @default.
- W2054991824 hasAuthorship W2054991824A5010370364 @default.
- W2054991824 hasAuthorship W2054991824A5032094148 @default.
- W2054991824 hasAuthorship W2054991824A5033369556 @default.
- W2054991824 hasAuthorship W2054991824A5064491755 @default.
- W2054991824 hasAuthorship W2054991824A5069820176 @default.
- W2054991824 hasAuthorship W2054991824A5077484679 @default.
- W2054991824 hasConcept C111684460 @default.
- W2054991824 hasConcept C118487528 @default.
- W2054991824 hasConcept C142724271 @default.
- W2054991824 hasConcept C202751555 @default.
- W2054991824 hasConcept C203014093 @default.
- W2054991824 hasConcept C2776882836 @default.
- W2054991824 hasConcept C2776914184 @default.
- W2054991824 hasConcept C2777063393 @default.
- W2054991824 hasConcept C2778275304 @default.
- W2054991824 hasConcept C2779257441 @default.
- W2054991824 hasConcept C2994251472 @default.
- W2054991824 hasConcept C529295009 @default.
- W2054991824 hasConcept C55493867 @default.
- W2054991824 hasConcept C71924100 @default.
- W2054991824 hasConcept C86803240 @default.
- W2054991824 hasConcept C8891405 @default.
- W2054991824 hasConceptScore W2054991824C111684460 @default.
- W2054991824 hasConceptScore W2054991824C118487528 @default.
- W2054991824 hasConceptScore W2054991824C142724271 @default.
- W2054991824 hasConceptScore W2054991824C202751555 @default.
- W2054991824 hasConceptScore W2054991824C203014093 @default.
- W2054991824 hasConceptScore W2054991824C2776882836 @default.
- W2054991824 hasConceptScore W2054991824C2776914184 @default.
- W2054991824 hasConceptScore W2054991824C2777063393 @default.
- W2054991824 hasConceptScore W2054991824C2778275304 @default.
- W2054991824 hasConceptScore W2054991824C2779257441 @default.
- W2054991824 hasConceptScore W2054991824C2994251472 @default.
- W2054991824 hasConceptScore W2054991824C529295009 @default.
- W2054991824 hasConceptScore W2054991824C55493867 @default.
- W2054991824 hasConceptScore W2054991824C71924100 @default.
- W2054991824 hasConceptScore W2054991824C86803240 @default.
- W2054991824 hasConceptScore W2054991824C8891405 @default.
- W2054991824 hasIssue "7" @default.
- W2054991824 hasLocation W20549918241 @default.
- W2054991824 hasLocation W20549918242 @default.
- W2054991824 hasOpenAccess W2054991824 @default.
- W2054991824 hasPrimaryLocation W20549918241 @default.
- W2054991824 hasRelatedWork W2007164544 @default.
- W2054991824 hasRelatedWork W2022501487 @default.
- W2054991824 hasRelatedWork W2035603658 @default.
- W2054991824 hasRelatedWork W2045538405 @default.
- W2054991824 hasRelatedWork W2063321046 @default.
- W2054991824 hasRelatedWork W2094882235 @default.
- W2054991824 hasRelatedWork W2145541639 @default.
- W2054991824 hasRelatedWork W2418202247 @default.
- W2054991824 hasRelatedWork W117156163 @default.
- W2054991824 hasRelatedWork W2742058698 @default.
- W2054991824 hasVolume "19" @default.
- W2054991824 isParatext "false" @default.
- W2054991824 isRetracted "false" @default.
- W2054991824 magId "2054991824" @default.
- W2054991824 workType "article" @default.