FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054992024> ?p ?o ?g. }

• W2054992024 endingPage "216.e1" @default.
• W2054992024 startingPage "210" @default.
• W2054992024 abstract "ObjectivesVarious types of surgical and interventional procedures have been reported to cause cardiac sympathetic denervation. We aimed at evaluating the effects of coronary artery bypass grafting (CABG) in cardiac sympathetic innervation through meta-iodobenzyl-guanidine (MIBG) imaging.MethodsMIBG imaging was performed in 21 patients with coronary artery disease (CAD) 1 day before and 1 week and 6 months after CABG with concomitant measurements of corrected QT interval. In each study we evaluated MIBG defect score in a 16-segment left ventricular model, MIBG-defect size (percent) from generated polar maps, and heart/mediastinum ratio.ResultsMean MIBG defect score and size were increased (32 ± 9.5 vs 24 ± 5, P < .0001, and 49.5% ± 20.4% vs 37% ± 8.7%, P = .004, respectively) and mean heart/mediastinum ratio was reduced (1.5 ± 0.4 vs 1.9 ± 0.3, P < .0001) at 1 week after CABG. At 6 months these indices had no significant differences compared with their pre-CABG values. Mean corrected QT interval demonstrated no significant changes. Increase in MIBG score in the second imaging was associated with adverse events related to arrhythmia and myocardial dysfunction during the 6-month follow-up period in a binary logistic regression model.ConclusionsCABG is associated with clinically important but reversible reduction in cardiac sympathetic nerve function, with periprocedural effects (cardioplegia, hypothermia, ischemia, direct nerve injury) being possible mechanisms for this finding. Various types of surgical and interventional procedures have been reported to cause cardiac sympathetic denervation. We aimed at evaluating the effects of coronary artery bypass grafting (CABG) in cardiac sympathetic innervation through meta-iodobenzyl-guanidine (MIBG) imaging. MIBG imaging was performed in 21 patients with coronary artery disease (CAD) 1 day before and 1 week and 6 months after CABG with concomitant measurements of corrected QT interval. In each study we evaluated MIBG defect score in a 16-segment left ventricular model, MIBG-defect size (percent) from generated polar maps, and heart/mediastinum ratio. Mean MIBG defect score and size were increased (32 ± 9.5 vs 24 ± 5, P < .0001, and 49.5% ± 20.4% vs 37% ± 8.7%, P = .004, respectively) and mean heart/mediastinum ratio was reduced (1.5 ± 0.4 vs 1.9 ± 0.3, P < .0001) at 1 week after CABG. At 6 months these indices had no significant differences compared with their pre-CABG values. Mean corrected QT interval demonstrated no significant changes. Increase in MIBG score in the second imaging was associated with adverse events related to arrhythmia and myocardial dysfunction during the 6-month follow-up period in a binary logistic regression model. CABG is associated with clinically important but reversible reduction in cardiac sympathetic nerve function, with periprocedural effects (cardioplegia, hypothermia, ischemia, direct nerve injury) being possible mechanisms for this finding." @default.
• W2054992024 created "2016-06-24" @default.
• W2054992024 creator A5045971594 @default.
• W2054992024 creator A5051364239 @default.
• W2054992024 creator A5065338654 @default.
• W2054992024 creator A5067898421 @default.
• W2054992024 creator A5074892437 @default.
• W2054992024 date "2012-07-01" @default.
• W2054992024 modified "2023-10-17" @default.
• W2054992024 title "Reversible reduction of cardiac sympathetic innervation after coronary artery bypass graft surgery: An observational study using serial iodine 123–labeled meta-iodobenzyl-guanidine (MIBG) imaging" @default.
• W2054992024 cites W1963950669 @default.
• W2054992024 cites W1970955271 @default.
• W2054992024 cites W1976823720 @default.
• W2054992024 cites W2005574970 @default.
• W2054992024 cites W2025800144 @default.
• W2054992024 cites W2031574873 @default.
• W2054992024 cites W2047820034 @default.
• W2054992024 cites W2064451797 @default.
• W2054992024 cites W2073392400 @default.
• W2054992024 cites W2079708798 @default.
• W2054992024 cites W2080496969 @default.
• W2054992024 cites W2090314055 @default.
• W2054992024 cites W2092424843 @default.
• W2054992024 cites W2122328683 @default.
• W2054992024 cites W2122599221 @default.
• W2054992024 cites W2135791682 @default.
• W2054992024 cites W2165939949 @default.
• W2054992024 cites W2280442366 @default.
• W2054992024 cites W2301665437 @default.
• W2054992024 cites W2401198460 @default.
• W2054992024 cites W4213156194 @default.
• W2054992024 doi "https://doi.org/10.1016/j.jtcvs.2012.03.005" @default.
• W2054992024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22487439" @default.
• W2054992024 hasPublicationYear "2012" @default.
• W2054992024 type Work @default.
• W2054992024 sameAs 2054992024 @default.
• W2054992024 citedByCount "5" @default.
• W2054992024 countsByYear W20549920242013 @default.
• W2054992024 countsByYear W20549920242017 @default.
• W2054992024 countsByYear W20549920242019 @default.
• W2054992024 crossrefType "journal-article" @default.
• W2054992024 hasAuthorship W2054992024A5045971594 @default.
• W2054992024 hasAuthorship W2054992024A5051364239 @default.
• W2054992024 hasAuthorship W2054992024A5065338654 @default.
• W2054992024 hasAuthorship W2054992024A5067898421 @default.
• W2054992024 hasAuthorship W2054992024A5074892437 @default.
• W2054992024 hasBestOaLocation W20549920241 @default.
• W2054992024 hasConcept C126322002 @default.
• W2054992024 hasConcept C164705383 @default.
• W2054992024 hasConcept C2776805190 @default.
• W2054992024 hasConcept C2776820930 @default.
• W2054992024 hasConcept C2778213512 @default.
• W2054992024 hasConcept C42219234 @default.
• W2054992024 hasConcept C71924100 @default.
• W2054992024 hasConceptScore W2054992024C126322002 @default.
• W2054992024 hasConceptScore W2054992024C164705383 @default.
• W2054992024 hasConceptScore W2054992024C2776805190 @default.
• W2054992024 hasConceptScore W2054992024C2776820930 @default.
• W2054992024 hasConceptScore W2054992024C2778213512 @default.
• W2054992024 hasConceptScore W2054992024C42219234 @default.
• W2054992024 hasConceptScore W2054992024C71924100 @default.
• W2054992024 hasIssue "1" @default.
• W2054992024 hasLocation W20549920241 @default.
• W2054992024 hasLocation W20549920242 @default.
• W2054992024 hasOpenAccess W2054992024 @default.
• W2054992024 hasPrimaryLocation W20549920241 @default.
• W2054992024 hasRelatedWork W115922469 @default.
• W2054992024 hasRelatedWork W2042629756 @default.
• W2054992024 hasRelatedWork W2050943580 @default.
• W2054992024 hasRelatedWork W2471376028 @default.
• W2054992024 hasRelatedWork W2579414041 @default.
• W2054992024 hasRelatedWork W2737884982 @default.
• W2054992024 hasRelatedWork W3113925325 @default.
• W2054992024 hasRelatedWork W4220660297 @default.
• W2054992024 hasRelatedWork W2124520542 @default.
• W2054992024 hasRelatedWork W2994454448 @default.
• W2054992024 hasVolume "144" @default.
• W2054992024 isParatext "false" @default.
• W2054992024 isRetracted "false" @default.
• W2054992024 magId "2054992024" @default.
• W2054992024 workType "article" @default.