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• W2054996318 abstract "Case Reports1 April 1962Focal Glomerular Lesions in Fungal EndocarditisWILLIAM C. ROBERTS, M.D., ALAN S. RABSON, M.D.WILLIAM C. ROBERTS, M.D.Search for more papers by this author, ALAN S. RABSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-610 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFocal areas of necrosis and sclerosis have frequently been seen in the renal glomeruli of autopsied patients with subacute endocarditis due to bacteria. These glomerular lesions have been called focal embolic (endocarditic) glomerulonephritis, with the implication that they were the result of multiple small emboli, which were dislodged from cardiac vegetations and landed in the glomerular capillaries. Allen (1) summarized the reasons for rejecting the embolic theory of the pathogenesis of these lesions and agreed with Longcope (2) who considered these lesions to be of an allergic nature. Since fungal infections in man are commonly associated with manifestations of hypersensitivity...References1. ALLEN AC: The Kidney, Medical and Surgical Diseases. Grune & Stratton, Inc., New York, 1951, pp. 164-170. Google Scholar2. LONGCOPE WT: The susceptibility of man to foreign proteins. Amer. J. Med. Sci. 152: 625, 1916. CrossrefGoogle Scholar3. ANDRIOLEKRAVETZROBERTSUTZ VTHMWCJP: Candida endocarditis: clinical and pathological studies. Amer. J. Med. 32: 251, 1962. CrossrefMedlineGoogle Scholar4. PASTERNACK JG: Subacute monilia endocarditis: new clinical and pathological entity. Amer. J. Clin. Path. 12: 496, 1942. CrossrefGoogle Scholar5. NIEL K: Zur Klinik der Candidainfektionen. Klin. Med. (Wien) 8: 49, 1953. Google Scholar6. KOHLMEIER W: Zur Kenntnis der Candidainfektionen. Klin. Med. (Wien) 8: 54, 1953. Google Scholar7. COOPERMORROWROBERTSHERMAN TAGWCLG: Postoperative endocarditis due to Candida: clinical observations and the experimental production of the lesion. Surgery 50: 341, 1961. Google Scholar8. MERCHANTLOURIAGEISLEREDGCOMBUTZ RKDBPHJHJP: Fungal endocarditis: review of the literature and report of three cases. Ann. Intern. Med. 48: 242, 1958. LinkGoogle Scholar9. BELL ET: Glomerular lesions associated with endocarditis. Amer. J. Path. 8: 639, 1932. MedlineGoogle Scholar10. BELL ET: Renal Diseases, Lea & Febiger, Philadelphia, 1950, pp. 165-169. Google Scholar11. BAEHR G: Glomerular lesions of subacute bacterial endocarditis. Amer. J. Med. Sci. 144: 327, 1912. CrossrefGoogle Scholar12. BAEHR G: Glomerular lesions of subacute bacterial endocarditis. J. Exp. Med. 15: 330, 1912. CrossrefMedlineGoogle Scholar13. FISHBERG AM: Hypertension and Nephritis, 5th ed., Lea & Febiger, Philadelphia, 1954, pp. 665-671. Google Scholar14. FAHR T: In Handbuch der Speziellen pathologischen Anatomie und Histologie, vol. 6, pt. 1, ed. by Henke, F., and Lubarsch, O. Springer, Berlin, 1925, pp. 355-362. Google Scholar15. KLEMPERERPOLLACKBAEHR PADG: Pathology of disseminated lupus erythematosus. Arch. Path. 32: 569, 1941. Google Scholar16. HEPTINSTALLJOEKES RHAM: Focal glomerulonephritis. Quart. J. Med. (new series) 28: 329, 1959. MedlineGoogle Scholar17. BATESJENNINGSEARLE RCRBDP: Acute nephritis unrelated to group A hemolytic streptococcus infection: report of ten cases. Amer. J. Med. 23: 510, 1957. CrossrefMedlineGoogle Scholar18. LÖHLEIN M: Ueber hämorrhagische Nierenaffektionen bei; chronischer ulzeröser Endokarditis. (Embolische nichteiterige Herdnephritis.) Med. Klin. 6: 375, 1910. Google Scholar19. BAINEDWARDSSCHEIFLEYGERACI RCJECHJE: Right-sided bacterial endocarditis and endarteritis. Amer. J. Med. 24: 98, 1958. CrossrefMedlineGoogle Scholar20. DRAKE CH: Quoted by Dubos, R. J. in Bacterial and Mycotic Infections of Man, 2d ed., J. B. Lippincott Company, Philadelphia, 1952, p. 664. Google Scholar21. KUSHNERSZANTO DSPB: Heart failure, fever, and splenomegaly in a morphine addict. J. A. M. A. 166: 2162, 1958. MedlineGoogle Scholar22. CASSELSSTEINER DP: Mycotic endocarditis: report of a case with necropsy: review of the literature. Amer. J. Dis. Child. 67: 128, 1944. CrossrefGoogle Scholar23. CAPLAN H: Monilia (Candida) endocarditis following treatment with antibiotics. Lancet 2: 957, 1955. CrossrefGoogle Scholar24. NICOLAIDES NJ: Fungal endocarditis complicating staphylococcal endocarditis. Med. J. Aust. 1: 793, 1957. CrossrefGoogle Scholar25. RICHARTDAMMIN RGJ: Candida tropicalis as a pathogen for man. New Engl. J. Med. 263: 474, 1960. CrossrefGoogle Scholar26. BOYARSKYBURNETTBARKER SJMWH: Renal failure in embolic glomerulonephritis as a complication of subacute bacterial endocarditis. Bull. Johns Hopkins Hosp. 84: 207, 1949. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Pathologic Anatomy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.Requests for reprints should be addressed to William C. Roberts, M.D., Pathologic Anatomy Department, Clinical Center, National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEndocardites à Candida : étude rétrospective de 12 patientsComparison of active infective endocarditis involving a previously stenotic versus a previously nonstenotic aortic valveCrescentic involved glomerulonephritis in infective endocarditisMesangio-capillary glomerulonephritis associated with Q-fever endocarditisRenal consequences of valvular heart diseaseBeitrag zur experimentellen Candidose des Respirationstraktes*The narcotic addict as a medical patientInfective Endocarditis in the Antibiotic EraAmphotericin B Nephrotoxicity with Irreversible Renal FailureFRANK J. TAKACS, M.D., ZYGMUNT M. TOMKIEWICZ, M.D., JOHN P. MERRILL, M.D., F.A.C.P. 1 April 1962Volume 56, Issue 4Page: 610-618KeywordsBacteriaCandidaCapillariesEndocarditisGlomerulonephritisHypersensitivityKidneysLesionsNecrosisPathogenesis Issue Published: 1 April 1962 PDF DownloadLoading ..." @default.
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