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• W2055000956 abstract "Abstract Autism spectrum disorder (ASD) is a behaviourally defined syndrome where the etiology and pathophysiology is only partially understood. In a small proportion of children with the condition, a specific medical disorder is identified, but the causal significance in many instances is unclear. Currently, the medical conditions that are best established as probable causes of ASD include Fragile X syndrome, Tuberous Sclerosis and abnormalities of chromosome 15 involving the 15q11-13 region. Various other single gene mutations, genetic syndromes, chromosomal abnormalities and rare de novo copy number variants have been reported as being possibly implicated in etiology, as have several ante and post natal exposures and complications. However, in most instances the evidence base for an association with ASD is very limited and largely derives from case reports or findings from small, highly selected and uncontrolled case series. Not only therefore, is there uncertainty over whether the condition is associated, but the potential basis for the association is very poorly understood. In some cases the medical condition may be a consequence of autism or simply represent an associated feature deriving from an underlying shared etiology. Nevertheless, it is clear that in a growing proportion of individuals potentially causal medical conditions are being identified and clarification of their role in etio-pathogenesis is necessary. Indeed, investigations into the causal mechanisms underlying the association between conditions such as tuberous sclerosis, Fragile X and chromosome 15 abnormalities are beginning to cast light on the molecular and neurobiological pathways involved in the pathophysiology of ASD. It is evident therefore, that much can be learnt from the study of probably causal medical disorders as they represent simpler and more tractable model systems in which to investigate causal mechanisms. Recent advances in genetics, molecular and systems biology and neuroscience now mean that there are unparalleled opportunities to test causal hypotheses and gain fundamental insights into the nature of autism and its development." @default.
• W2055000956 created "2016-06-24" @default.
• W2055000956 creator A5030755834 @default.
• W2055000956 date "2009-06-01" @default.
• W2055000956 modified "2023-10-14" @default.
• W2055000956 title "Medical conditions in autism spectrum disorders" @default.
• W2055000956 cites W1484523836 @default.
• W2055000956 cites W1525396451 @default.
• W2055000956 cites W1532238452 @default.
• W2055000956 cites W1577610769 @default.
• W2055000956 cites W1865706782 @default.
• W2055000956 cites W193424008 @default.
• W2055000956 cites W1938895434 @default.
• W2055000956 cites W1964099928 @default.
• W2055000956 cites W1964504066 @default.
• W2055000956 cites W1965825816 @default.
• W2055000956 cites W1966277592 @default.
• W2055000956 cites W1967308504 @default.
• W2055000956 cites W1968608231 @default.
• W2055000956 cites W1969763493 @default.
• W2055000956 cites W1969953407 @default.
• W2055000956 cites W1970009362 @default.
• W2055000956 cites W1970755818 @default.
• W2055000956 cites W1971321176 @default.
• W2055000956 cites W1973875834 @default.
• W2055000956 cites W1976358763 @default.
• W2055000956 cites W1978778635 @default.
• W2055000956 cites W1979250362 @default.
• W2055000956 cites W1980056577 @default.
• W2055000956 cites W1980309199 @default.
• W2055000956 cites W1983020854 @default.
• W2055000956 cites W1983111444 @default.
• W2055000956 cites W1983194657 @default.
• W2055000956 cites W1984619141 @default.
• W2055000956 cites W1985123841 @default.
• W2055000956 cites W1985453974 @default.
• W2055000956 cites W1985840371 @default.
• W2055000956 cites W1986465231 @default.
• W2055000956 cites W1987706867 @default.
• W2055000956 cites W1993508868 @default.
• W2055000956 cites W1993541380 @default.
• W2055000956 cites W1995385582 @default.
• W2055000956 cites W1995779689 @default.
• W2055000956 cites W1997031801 @default.
• W2055000956 cites W2002938212 @default.
• W2055000956 cites W2003157794 @default.
• W2055000956 cites W2004017086 @default.
• W2055000956 cites W2005585817 @default.
• W2055000956 cites W2005817756 @default.
• W2055000956 cites W2007282648 @default.
• W2055000956 cites W2007448008 @default.
• W2055000956 cites W2010246526 @default.
• W2055000956 cites W2010537604 @default.
• W2055000956 cites W2012387407 @default.
• W2055000956 cites W2012775152 @default.
• W2055000956 cites W2013192070 @default.
• W2055000956 cites W2013286117 @default.
• W2055000956 cites W2013336853 @default.
• W2055000956 cites W2013633438 @default.
• W2055000956 cites W2017221278 @default.
• W2055000956 cites W2017429826 @default.
• W2055000956 cites W2018542718 @default.
• W2055000956 cites W2019433658 @default.
• W2055000956 cites W2020682391 @default.
• W2055000956 cites W2022504874 @default.
• W2055000956 cites W2023122132 @default.
• W2055000956 cites W2025470742 @default.
• W2055000956 cites W2027173704 @default.
• W2055000956 cites W2027732400 @default.
• W2055000956 cites W2028251241 @default.
• W2055000956 cites W2029591740 @default.
• W2055000956 cites W2029842229 @default.
• W2055000956 cites W2033447318 @default.
• W2055000956 cites W2033742599 @default.
• W2055000956 cites W2034916905 @default.
• W2055000956 cites W2035581146 @default.
• W2055000956 cites W2036022156 @default.
• W2055000956 cites W2038648070 @default.
• W2055000956 cites W2038649758 @default.
• W2055000956 cites W2038869071 @default.
• W2055000956 cites W2043063565 @default.
• W2055000956 cites W2044709288 @default.
• W2055000956 cites W2046265374 @default.
• W2055000956 cites W2047674796 @default.
• W2055000956 cites W2048612819 @default.
• W2055000956 cites W2048994465 @default.
• W2055000956 cites W2050947021 @default.
• W2055000956 cites W2052196244 @default.
• W2055000956 cites W2053340374 @default.
• W2055000956 cites W2053486980 @default.
• W2055000956 cites W2055573605 @default.
• W2055000956 cites W2056288663 @default.
• W2055000956 cites W2061869968 @default.
• W2055000956 cites W2062260214 @default.
• W2055000956 cites W2062874224 @default.
• W2055000956 cites W2063649678 @default.
• W2055000956 cites W2065894981 @default.
• W2055000956 cites W2073469729 @default.

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