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- W2055015089 abstract "WE have made the following suggestions to explain the incidence and location of the tumours produced in rats with 4-aminodiphenyl and some of its nuclear methylated derivatives1. First, that in each instance the effective carcinogen is the corresponding ortho-hydroxy amine, formed in the liver and excreted in the bile; secondly, that 4-aminodiphenyl itself is largely metabolized to the 4′-hydroxy derivative and that little of the ortho-hydroxy amine, 3-hydroxy-4-aminodiphenyl, is formed; and finally, that in the metabolism of the more actively carcinogenic derivatives of 4-aminodiphenyl containing a methyl substituent in the 3 position, relatively more of the corresponding ortho-hydroxy amines are produced." @default.
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- W2055015089 date "1955-06-01" @default.
- W2055015089 modified "2023-09-26" @default.
- W2055015089 title "Tumours induced in Rats with 4′-Fluoro-4-Aminodiphenyl" @default.
- W2055015089 cites W1974094734 @default.
- W2055015089 doi "https://doi.org/10.1038/1751131a0" @default.
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