FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055036355> ?p ?o ?g. }

• W2055036355 abstract "Brief Abstract A 75-year-old man presented with B-CLL followed by a CML. We retrospectively analyzed the frozen BM and PB lymphocytes that evidenced 2 distinct clonal proliferations: one is a B CD5+/CD19+ lymphocyte population, without BCR-ABL fusion; the other is the CD19+ mononuclear cell population expressing traces of BCR-ABL, 3 years before the occurrence of CML. We suggest that (1) the emergence of the Ph+ clone after the treatment of CLL is probably related to RFC-induced immunosuppression, and (2) the long DFS of CLL might be due to the current TK inhibitor treatment Full Abstract Introduction The coexistence of B-cell chronic lymphocytic leukemia (B-CLL) and chronic myeloid leukemia (CML) is a rare event. This coexistence has led to speculation of the clonal origin of these neoplasms. In some cases, 2 independent clones were demonstrated. Patients and Methods A 75-year-old man presented with splenomegaly and enlarged lymph nodes. Immunophenotype (kappa, CD19+, CD5+, CD23+) was compatible with B-CLL. Bone marrow examination showed infiltration by small lymphocytes next to a myeloid and megakaryocytic hyperplasia. Cytogenetic analysis of the marrow showed 46XY, del(16q). Philadelphia chromosome (Ph) was negative. The patient was diagnosed with B-CLL and treated by 6 RFC (rituximab/fludarabine/cyclophosphamide). He reached a molecular remission (MCR), but 3 years after the treatment for CLL, he developed hyperleukocytosis (26000/μL), mainly myeloid cells. Bone marrow smear demonstrated a myeloid hyperplasia with predominance of immature progenitors. The Ph was clearly evidenced, and CML was confirmed. The patient thus received thus imatinib 400 mg/day orally with hematologic but only partial molecular remission at 18 months. A Y25.3H mutation was detected, and the patient was switched to dasatinib with a successful evolution. The CLL remained in MCR during this 5-year period. Results To know whether CML is a secondary event induced by RFC treatment or the emergence of a latent CML clone, we analyzed retrospectively the frozen BM and PBL lymphocytes. The results were consistent with the view that there are 2 distinct clonal proliferations: one is a clonal B CD5+/CD19+ lymphocyte population, without BCR-ABL fusion; the other is the CD19+ mononuclear cell population expressing traces of BCR-ABL, 3 years before the occurrence of CML. Conclusion Our data provide evidence for a separate clonal origin for each disorder, raising the hypothesis that (1) the emergence of the Ph+ clone after the treatment of CLL is probably related to RFC-induced immunosuppression, and (2) the long disease-free survival of CLL might be due to the current tyrosine kinase inhibitor treatment." @default.
• W2055036355 created "2016-06-24" @default.
• W2055036355 creator A5001584203 @default.
• W2055036355 creator A5008242911 @default.
• W2055036355 creator A5026818413 @default.
• W2055036355 creator A5038795221 @default.
• W2055036355 creator A5053031492 @default.
• W2055036355 creator A5078645753 @default.
• W2055036355 creator A5080398679 @default.
• W2055036355 date "2009-12-01" @default.
• W2055036355 modified "2023-09-23" @default.
• W2055036355 title "Concomitant or Sequential Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML): A Molecular and Clinical Survey" @default.
• W2055036355 doi "https://doi.org/10.3816/clm.2009.n.096" @default.
• W2055036355 hasPublicationYear "2009" @default.
• W2055036355 type Work @default.
• W2055036355 sameAs 2055036355 @default.
• W2055036355 citedByCount "0" @default.
• W2055036355 crossrefType "journal-article" @default.
• W2055036355 hasAuthorship W2055036355A5001584203 @default.
• W2055036355 hasAuthorship W2055036355A5008242911 @default.
• W2055036355 hasAuthorship W2055036355A5026818413 @default.
• W2055036355 hasAuthorship W2055036355A5038795221 @default.
• W2055036355 hasAuthorship W2055036355A5053031492 @default.
• W2055036355 hasAuthorship W2055036355A5078645753 @default.
• W2055036355 hasAuthorship W2055036355A5080398679 @default.
• W2055036355 hasConcept C113067387 @default.
• W2055036355 hasConcept C126322002 @default.
• W2055036355 hasConcept C142724271 @default.
• W2055036355 hasConcept C147483822 @default.
• W2055036355 hasConcept C196166836 @default.
• W2055036355 hasConcept C203014093 @default.
• W2055036355 hasConcept C2776694085 @default.
• W2055036355 hasConcept C2776755627 @default.
• W2055036355 hasConcept C2777938653 @default.
• W2055036355 hasConcept C2778461978 @default.
• W2055036355 hasConcept C2778729363 @default.
• W2055036355 hasConcept C2779263901 @default.
• W2055036355 hasConcept C2779282312 @default.
• W2055036355 hasConcept C2779338263 @default.
• W2055036355 hasConcept C2780007613 @default.
• W2055036355 hasConcept C2908647359 @default.
• W2055036355 hasConcept C71924100 @default.
• W2055036355 hasConcept C99454951 @default.
• W2055036355 hasConceptScore W2055036355C113067387 @default.
• W2055036355 hasConceptScore W2055036355C126322002 @default.
• W2055036355 hasConceptScore W2055036355C142724271 @default.
• W2055036355 hasConceptScore W2055036355C147483822 @default.
• W2055036355 hasConceptScore W2055036355C196166836 @default.
• W2055036355 hasConceptScore W2055036355C203014093 @default.
• W2055036355 hasConceptScore W2055036355C2776694085 @default.
• W2055036355 hasConceptScore W2055036355C2776755627 @default.
• W2055036355 hasConceptScore W2055036355C2777938653 @default.
• W2055036355 hasConceptScore W2055036355C2778461978 @default.
• W2055036355 hasConceptScore W2055036355C2778729363 @default.
• W2055036355 hasConceptScore W2055036355C2779263901 @default.
• W2055036355 hasConceptScore W2055036355C2779282312 @default.
• W2055036355 hasConceptScore W2055036355C2779338263 @default.
• W2055036355 hasConceptScore W2055036355C2780007613 @default.
• W2055036355 hasConceptScore W2055036355C2908647359 @default.
• W2055036355 hasConceptScore W2055036355C71924100 @default.
• W2055036355 hasConceptScore W2055036355C99454951 @default.
• W2055036355 hasLocation W20550363551 @default.
• W2055036355 hasOpenAccess W2055036355 @default.
• W2055036355 hasPrimaryLocation W20550363551 @default.
• W2055036355 hasRelatedWork W1996499771 @default.
• W2055036355 hasRelatedWork W2021328736 @default.
• W2055036355 hasRelatedWork W2026240559 @default.
• W2055036355 hasRelatedWork W2082960682 @default.
• W2055036355 hasRelatedWork W2121676675 @default.
• W2055036355 hasRelatedWork W2362036578 @default.
• W2055036355 hasRelatedWork W2396405351 @default.
• W2055036355 hasRelatedWork W2549804860 @default.
• W2055036355 hasRelatedWork W2585193691 @default.
• W2055036355 hasRelatedWork W2621284904 @default.
• W2055036355 hasRelatedWork W2896810963 @default.
• W2055036355 hasRelatedWork W2913398746 @default.
• W2055036355 hasRelatedWork W2945506433 @default.
• W2055036355 hasRelatedWork W2959890717 @default.
• W2055036355 hasRelatedWork W2976008859 @default.
• W2055036355 hasRelatedWork W2980804644 @default.
• W2055036355 hasRelatedWork W3006323524 @default.
• W2055036355 hasRelatedWork W3028387934 @default.
• W2055036355 hasRelatedWork W3091341067 @default.
• W2055036355 hasRelatedWork W3200530306 @default.
• W2055036355 isParatext "false" @default.
• W2055036355 isRetracted "false" @default.
• W2055036355 magId "2055036355" @default.
• W2055036355 workType "article" @default.